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Apoptosis signaling pathway

Apoptosis is an evolutionarily conserved mechanism for the selective removal of aging, damaged or otherwise unwanted cells. It plays a fundamental role in many physiological processes such as tissue development, and the immune response. Thus, regulation of apoptosis is important for tissue homeostasis and its deregulation can lead to a variety of pathological conditions including carcinogenesis and chemoresistance.
Apoptosis is mediated primarily through promoting or inhibiting the activation of caspases. Caspases are effectors of cell suicide and cleave multiple substrates, leading to biochemical and morphological changes including mitochondrial outer membrane permeabilization; cell membrane remodeling and blebbing; cell shrinkage; nuclear condensation; and DNA fragmentation. In mammalian systems, the extrinsic death receptor pathway, the intrinsic mitochondrial pathway and endoplasmic reticulum pathway are the major signaling systems that result in the activation of the executioner/effector caspases and the consequent demise of the cell. All pathways eventually lead to a common pathway or the execution phase of apoptosis. Understanding the apoptosis mechanisms is important and helpful to us in the understanding of the pathogenesis of conditions as a result of disordered apoptosis. Meanwhile, it may help in the development of drugs that target certain apoptotic genes or pathways.

Product Name Code Uniprot No. Species Reactivity Application
AATF Antibody CSB-PA05264A0Rb Q9NY61 Human ELISA/IHC
ABL1 Antibody CSB-PA04355A0Rb P00519 Human ELISA/IHC/IP
ACAA2 Antibody CSB-PA001118LA01HU P42765 Human, Mouse, Rat ELISA/WB/IHC/IF/IP
ACSL5 Antibody CSB-PA891734HA01HU Q9ULC5 Human, Rat ELISA/WB/IHC
ACTL6A Antibody CSB-PA001236ESR2HU O96019 Human, Mouse ELISA/WB/IHC/CHIP
ACVR1C Antibody CSB-PA854112ESR1HU Q8NER5 Human, Mouse ELISA/WB/IHC
ADAMTSL4 Antibody CSB-PA761506ESR1HU Q6UY14 Human ELISA/IHC
ADRM1 Antibody CSB-PA001396HA01HU Q16186 Human, Mouse ELISA/WB/IHC/IF
AEN Antibody CSB-PA819883LA01HU Q8WTP8 Human ELISA/IF
AGER Antibody CSB-PA14209A0Rb Q15109 Human, Mouse ELISA/IHC/IF
AIFM1 Antibody CSB-PA001492HA01HU O95831 Human ELISA/WB/IHC/IF
AIM2 Antibody CSB-PA001499LA01HU O14862 Human ELISA/WB/IHC/IF
AIMP1 Antibody CSB-PA618638DSR1HU Q12904 Human ELISA/WB/IHC/IP
AIMP2 Antibody CSB-PA819153ESR1HU Q13155 Human ELISA/WB/IHC
AK6 Antibody CSB-PA619078ESR1HU Q9Y3D8 Human ELISA/WB/IHC
AKT1 Antibody CSB-PA15905A0RB P31749 Human ELISA/IHC/IF/ChIp
AKT2 Antibody CSB-PA15919A0Rb P31751 Human, Rat ELISA/WB/IHC/IF
AKT3 Antibody CSB-PA15929A0Rb Q9Y243 Human, Mouse ELISA/IP
AKTIP Antibody CSB-PA862043ESR2HU Q9H8T0 Human ELISA/IHC
ALKBH8 Antibody CSB-PA842644ESR1HU Q96BT7 Human ELISA/IHC
IF
CAMLG Antibody
CSB-PA004475LA01HU
S1PR3 Antibody
CSB-PA859932LA01HU
NUPR1 Antibody
CSB-PA527662LA01HU
FATE1 Antibody
CSB-PA839274LA01HU
IHC
KRT18 Antibody
CSB-PA10629A0Rb
WISP1 Antibody
CSB-PA026119LA01HU
DRAM1 Antibody
CSB-PA836675LA01HU
XPO1 Antibody
CSB-PA026221LA01HU
WB
TMBIM1 Antibody
CSB-PA853376LA01HU
ACTL6A Antibody
CSB-PA001236ESR2HU
IP
CDK2 Antibody
CSB-PA005061LA01HU
EIF3F Antibody
CSB-PA007535ESR2HU
TIA1 Antibody
CSB-PA023527DSR1HU
AIMP1 Antibody
CSB-PA618638DSR1HU
ChIP
NFKB1 Antibody
CSB-PA10354A0Rb
AKT1 Antibody
CSB-PA15905A0RB

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