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Apoptosis signaling pathway

Apoptosis is an evolutionarily conserved mechanism for the selective removal of aging, damaged or otherwise unwanted cells. It plays a fundamental role in many physiological processes such as tissue development, and the immune response. Thus, regulation of apoptosis is important for tissue homeostasis and its deregulation can lead to a variety of pathological conditions including carcinogenesis and chemoresistance.
Apoptosis is mediated primarily through promoting or inhibiting the activation of caspases. Caspases are effectors of cell suicide and cleave multiple substrates, leading to biochemical and morphological changes including mitochondrial outer membrane permeabilization; cell membrane remodeling and blebbing; cell shrinkage; nuclear condensation; and DNA fragmentation. In mammalian systems, the extrinsic death receptor pathway, the intrinsic mitochondrial pathway and endoplasmic reticulum pathway are the major signaling systems that result in the activation of the executioner/effector caspases and the consequent demise of the cell. All pathways eventually lead to a common pathway or the execution phase of apoptosis. Understanding the apoptosis mechanisms is important and helpful to us in the understanding of the pathogenesis of conditions as a result of disordered apoptosis. Meanwhile, it may help in the development of drugs that target certain apoptotic genes or pathways.

Product Name Code Uniprot No. Species Reactivity Application
ACAA2 Antibody CSB-PA001118LA01HU P42765 Human, Mouse, Rat WB/IHC/IF
ACSL5 Antibody CSB-PA891734HA01HU Q9ULC5 Human, Rat WB/IHC
ACTL6A Antibody CSB-PA001236ESR2HU O96019 Human, Mouse WB/IHC/CHIP
ACVR1C Antibody CSB-PA854112ESR1HU Q8NER5 Human, Mouse WB/IHC
ADRM1 Antibody CSB-PA001396HA01HU Q16186 Human, Mouse WB/IHC/IF
AGER Antibody CSB-PA14209A0Rb Q15109 Human, Mouse WB/IHC
AIM2 Antibody CSB-PA001499LA01HU O14862 Human WB/IHC/IF
AIMP1 Antibody CSB-PA618638DSR1HU Q12904 Human WB/IHC/IP
AIMP2 Antibody CSB-PA819153ESR1HU Q13155 Human WB/IHC
AK6 Antibody CSB-PA619078ESR1HU Q9Y3D8 Human WB/IHC
AKT1 Antibody CSB-PA15905A0RB P31749 Human WB/IHC/CHIP
AMIGO2 Antibody CSB-PA769765LA01HU Q86SJ2 Human, Mouse WB/IHC
Angpt2 Antibody CSB-PA16959A0Rb O35608 Mouse WB/IHC
ANGPTL4 Antibody CSB-PA866314ESR2HU Q9BY76 Human, Mouse WB/IHC
ANKRD1 Antibody CSB-PA618002ESR2HU Q15327 Human, Rat WB/IHC
APIP Antibody CSB-PA839332ESR1HU Q96GX9 Human, Mouse WB/IHC
APP Antibody CSB-PA07179A0Rb P05067 Human, Mouse WB/IHC/IF
ARMC10 Antibody CSB-PA854026LA01HU Q8N2F6 Human, Mouse WB/IHC
ARRB2 Antibody CSB-PA002135LA01HU P32121 Human, Rat WB/IHC/IF
ASAH2 Antibody CSB-PA002170EA01HU Q9NR71 Human, Rat WB/IHC
IF
CAMLG Antibody
CSB-PA004475LA01HU
S1PR3 Antibody
CSB-PA859932LA01HU
NUPR1 Antibody
CSB-PA527662LA01HU
FATE1 Antibody
CSB-PA839274LA01HU
IHC
KRT18 Antibody
CSB-PA10629A0Rb
WISP1 Antibody
CSB-PA026119LA01HU
DRAM1 Antibody
CSB-PA836675LA01HU
XPO1 Antibody
CSB-PA026221LA01HU
WB
TMBIM1 Antibody
CSB-PA853376LA01HU
ACTL6A Antibody
CSB-PA001236ESR2HU
IP
CDK2 Antibody
CSB-PA005061LA01HU
EIF3F Antibody
CSB-PA007535ESR2HU
TIA1 Antibody
CSB-PA023527DSR1HU
AIMP1 Antibody
CSB-PA618638DSR1HU
ChIP
NFKB1 Antibody
CSB-PA10354A0Rb
AKT1 Antibody
CSB-PA15905A0RB

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