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| Code | CSB-AP003101MOW |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (Shop online in the US. Customers outside the US, please order from local distributors.) |
| Uniprot No. | P51494 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | Lyophilized from a 0.2 ?m filtered concentrated solution in 50 mM Tris-HCl, pH9.0, 600 mM NaCl, with 0.02 % Tween-20. |
| Alias | IL-6 |
| Species | Macaca mulatta (Rhesus macaque) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg. |
| Purity | >97% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | M+APVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM |
| Research Area | Immunology |
| Source | E.Coli |
| Gene Names | IL6 |
| Expression Region | 28-212aa |
| Tag Info | Tag-Free |
| Mol. Weight | 21.1 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 7561102 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). |
| Subcellular Location | Secreted |
| Protein Families | IL-6 superfamily |
| Database Links |
STRING: 9544.ENSMMUP00000026278 UniGene: Mmu.3376 |
| Pathway |
HIF-1 signaling pathway
Jak-STAT signaling pathway PI3K-Akt signaling pathway TNF signaling pathway Cellular senescence Hematopoietic cell lineage IL-17 signaling pathway NOD-like receptor signaling pathway Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway Inflammatory Pain |
IL6 Proteins for Macaca mulatta (Rhesus macaque)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011664MOW CSB-EP011664MOW CSB-BP011664MOW CSB-MP011664MOW |
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 ELISA Kit for Monkey
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E10050Mo | Monkey Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
Recombinant Hepatitis E virus genotype 3 Capsid protein(ORF2) ,partial
Express system: E.coli
Species: Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)
Recombinant Human Nuclear receptor subfamily 4 group A member 2(NR4A2)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Collagen alpha-1(XVIII) chain(COL18A1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human ATP synthase subunit alpha, mitochondrial(ATP5F1A)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Peroxisome proliferator-activated receptor gamma(Pparg)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Diacylglycerol kinase gamma(DGKG),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Thy-1 membrane glycoprotein(Thy1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Glutathione S-transferase A2(GSTA2)
Express system: E.coli
Species: Homo sapiens (Human)
