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| Code | CSB-AP001741HU |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (Shop online in the US. Customers outside the US, please order from local distributors.) |
| Uniprot No. | P05231 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH 7.4. ,lyophilized |
| Alias | IL-6, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor |
| Species | Homo sapiens (Human) |
| Biological_Activity | Assay #1: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg. Assay #2: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine T1165 cells is less than 0.8 ng/ml, corresponding to a specific activity of >1.25x106 IU/mg. |
| Purity | >96% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | IL6 |
| Expression Region | 30-212aa |
| Tag Info | Tag-Free |
| Mol. Weight | 20.7 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 15489334; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960; 9769329; 11001912; 11355017; 12768442; 26091039 |
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| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| Involvement in disease | Rheumatoid arthritis systemic juvenile (RASJ) |
| Subcellular Location | Secreted |
| Protein Families | IL-6 superfamily |
| Database Links |
HGNC: 6018 OMIM: 147620 KEGG: hsa:3569 STRING: 9606.ENSP00000258743 UniGene: Hs.654458 |
| Pathway |
HIF-1 signaling pathway
Jak-STAT signaling pathway PI3K-Akt signaling pathway TNF signaling pathway Cellular senescence Hematopoietic cell lineage IL-17 signaling pathway NOD-like receptor signaling pathway Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway Inflammatory Pain |
IL6 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA06757B0Rb | IL6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06757C0Rb | IL6 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA06757D0Rb | IL6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005546 | IL6 Antibody | Human | WB,ELISA |
IL6 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA06757A0Rb | IL6 Antibody | Human, Mouse | ELISA, WB, IHC |
IL6 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP011664HU | Recombinant Human Interleukin-6(IL6),Escherichia Coli | E.coli |
| CSB-AP004301HU | Recombinant Human Interleukin-6(IL6),partial (Active) | E.coli |
| CSB-AP005841HU | Recombinant Human Interleukin-6(IL6),partial (Active) (GMP) | E.Coli |
| CSB-YP011664HU CSB-BP011664HU CSB-MP011664HU |
Recombinant Human Interleukin-6(IL6) | Yeast Baculovirus Mammalian cell |
| CSB-RP067544h | Recombinant Human Interleukin-6(IL6) | E.coli |
IL6 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04638h | Human Interleukin 6,IL-6 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, urine | 2.453 pg/mL |
Recombinant Rat Acetyl-CoA carboxylase 1(Acaca),partial
Express system: Yeast
Species: Rattus norvegicus (Rat)
Recombinant Human Zinc finger protein GLI2(GLI2),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Mouse Interleukin-2 receptor subunit beta(Il2rb),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human High affinity immunoglobulin epsilon receptor subunit gamma(FCER1G),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Ras-related protein Rap-2b(RAP2B)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Immunoglobulin J chain(Jchain)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Integrin alpha-IIb(ITGA2B),partial
Express system: E.coli
Species: Homo sapiens (Human)
