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| Code | CSB-AP001741HU |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | P05231 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH 7.4. ,lyophilized |
| Alias | IL-6, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor |
| Species | Homo sapiens (Human) |
| Biological_Activity | Assay #1: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg. Assay #2: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine T1165 cells is less than 0.8 ng/ml, corresponding to a specific activity of >1.25x106 IU/mg. |
| Purity | >96% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | IL6 |
| Expression Region | 30-212aa |
| Tag Info | Tag-Free |
| Mol. Weight | 20.7 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 15489334; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960; 9769329; 11001912; 11355017; 12768442; 26091039 |
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| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| Involvement in disease | Rheumatoid arthritis systemic juvenile (RASJ) |
| Subcellular Location | Secreted |
| Protein Families | IL-6 superfamily |
| Database Links |
HGNC: 6018 OMIM: 147620 KEGG: hsa:3569 STRING: 9606.ENSP00000258743 UniGene: Hs.654458 |
| Pathway |
HIF-1 signaling pathway
Jak-STAT signaling pathway PI3K-Akt signaling pathway TNF signaling pathway Cellular senescence Hematopoietic cell lineage IL-17 signaling pathway NOD-like receptor signaling pathway Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway Inflammatory Pain |
IL6 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA06757B0Rb | IL6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06757C0Rb | IL6 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA06757A0Rb | IL6 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA06757D0Rb | IL6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005546 | IL6 Antibody | Human | WB,ELISA |
IL6 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-EAP06755 | IL6 Antibody Pair | Pig,Dog | S-ELISA |
IL6 Antibodies for Macaca thibetana (Pere David's macaque) (Tibetan macaque)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA686313XA01FVG | IL6 Antibody | Macaca thibetana (Pere David's macaque) (Tibetan macaque) | ELISA, WB (ensure identification of antigen) |
IL6 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011664BO CSB-EP011664BO CSB-BP011664BO CSB-MP011664BO |
Recombinant Bovine Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011664DO CSB-EP011664DO CSB-BP011664DO CSB-MP011664DO |
Recombinant Dog Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Sus scrofa (Pig)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011664PI CSB-EP011664PI CSB-BP011664PI CSB-MP011664PI |
Recombinant Pig Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Felis catus (Cat) (Felis silvestris catus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011664CA CSB-EP011664CA CSB-BP011664CA CSB-MP011664CA |
Recombinant Cat Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP305249MOV CSB-EP305249MOV CSB-BP305249MOV CSB-MP305249MOV |
Recombinant Macaca fascicularis Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP322670RA CSB-EP322670RA CSB-BP322670RA CSB-MP322670RA |
Recombinant Rat Interleukin-6(Il6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Neovison vison (American mink) (Mustela vison)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP336891MVE CSB-EP336891MVE CSB-BP336891MVE CSB-MP336891MVE |
Recombinant Mustela vison Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP342020DRI CSB-EP342020DRI CSB-BP342020DRI CSB-MP342020DRI |
Recombinant Cercocebus atys Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Mustela putorius furo (European domestic ferret) (Mustela furo)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP385261MOH CSB-EP385261MOH CSB-BP385261MOH CSB-MP385261MOH |
Recombinant Mustela putorius furo Interleukin-6(IL6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 Proteins for Sparus aurata (Gilthead sea bream)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP466936FJX CSB-EP466936FJX CSB-BP466936FJX CSB-MP466936FJX |
Recombinant Sparus aurata Interleukin-6(il6) | Yeast E.coli Baculovirus Mammalian cell |
IL6 cDNA for Sus scrofa (Pig)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL011664PI | IL6 | pUC | NM_214399.1 |
IL6 cDNA for Ovis aries (Sheep)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL011664SH | IL6 | pUC | NM_001009392.1 |
IL6 cDNA for Gallus gallus (Chicken)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL856206CH | IL6 | pUC | NM_204628.1 |
IL6 cDNA for Equus caballus (Horse)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL856767HO | IL6 | pUC | NM_001082496.1 |
IL6 ELISA Kit for Bos taurus (Bovine)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E12899B | Bovine Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 2.5 pg/mL |
IL6 ELISA Kit for Gallus gallus (Chicken)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08549Ch | Chicken Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL6 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E11260c | Dog Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
IL6 ELISA Kit for Capra hircus (Goat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E14360G | Goat Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
IL6 ELISA Kit for Monkey
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E10050Mo | Monkey Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
IL6 ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04639m | Mouse Interleukin 6,IL-6 ELISA KIT | serum, plasma, cell culture supernates | 0.39 pg/mL |
IL6 ELISA Kit for Sus scrofa (Pig)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E06786p | Pig Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 0.31 pg/mL |
IL6 ELISA Kit for Oryctolagus cuniculus (Rabbit)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E06903Rb | Rabbit Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL6 ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04640r | Rat Interleukin 6,IL-6 ELISA KIT | serum, plasma, tissue homogenates | 0.078 pg/mL |
IL6 ELISA Kit for Ovis aries (Sheep)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E10116Sh | Sheep Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 2 pg/mL |
IL6 ELISA Kit for Fish
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E13258Fh | Fish Interleukin 6,IL-6 ELISA Kit | serum, plasma, tissue homogenates | 12.5 pg/mL |
IL6 ELISA Kit for Equus caballus (Horse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E16634Hs | Horse Interleukin 6(IL-6)ELISA Kit | serum, plasma, tissue homogenates | 0.78 pg/mL |
IL6 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04638h | Human Interleukin 6,IL-6 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, urine | 2.453 pg/mL |
Recombinant Human Interferon-induced, double-stranded RNA-activated protein kinase(EIF2AK2)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Mouse Glutaminyl-peptide cyclotransferase(Qpct)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human 60S acidic ribosomal protein P2(RPLP2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Dopamine beta-hydroxylase(DBH)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Rat Suppressor of cytokine signaling 3(Socs3)
Express system: Yeast
Species: Rattus norvegicus (Rat)
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