ELISA Kits for Tumor Marker Research

Tumor markers (TM), produced by cancer cells or other cells, are a group of substances that reflect cancer-related information. They play important roles in early cancer screening, assisting in diagnosis, observing treatment efficacy, monitoring recurrence, and evaluating prognosis. An ideal tumor marker should possess high specificity, strong sensitivity, good stability, easy detection, and close clinical relevance. In recent years, with the development of precision medicine, tumor markers have gained increasing attention. Expanding our understanding of tumor markers can provide more references and support for gaining insights into the mechanisms of tumor development, clinical theories related to diagnosis and treatment, and further exploration of novel tumor markers.

CUSABIO is committed to providing researchers with highly accurate and sensitive tumor marker ELISA kits. These kits cover a variety of common tumor markers such as ACTH, AFP, CEA, hCG, CA 15-3, CA 19-9, CA125, NSE, and more. They enable rapid and quantitative detection of specific tumor markers, facilitating in-depth research into the molecular mechanisms of malignant tumor development and exploration of new tumor treatment strategies. Our kits provide precise and reliable data support for your scientific research, helping you achieve breakthroughs in the field of oncology.

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1.Overview of Tumor Markers

1.1 What Are Tumor Markers?

Tumor marker refers to any substance produced by cancer cells or normal (non-cancer) cells in response to cancer in organisms. In the traditional sense, tumor markers refer to protein or other substances produced by cancer cells. These markers are high in content and can be detected in blood, urine, feces, tumor tissues or other tissues and body fluids of some cancer patients. In addition, gene expression patterns and DNA changes (such as mutations and other changes) can also be used as tumor markers. The results of tumor markers are not usually used for diagnosis alone, but combined with clinical symptoms and imaging research can provide clues for the diagnosis and treatment of cancer.

Some tumor markers provide information about only one specific type of cancer, while others provide information about more than one cancer.

1.2 Why Perform Tumor Marker Testing?

Cancer screening: Screening for cancer in people with a specific family history of cancer but no symptoms.

Help diagnose cancer: Tumor markers can not be used to diagnose cancer alone, but are usually combined with the results of other tests (such as biopsy or imaging) to diagnose cancer.

Monitor cancer progress and treatment efficacy: Cancer progress can also be monitored by measuring tumor markers regularly during cancer treatment. For example, a decrease in the level of tumor markers may indicate that the treatment is working, and vice versa.

Monitor for cancer recurrence: For some cancers, the increase of specific tumor markers may indicate cancer recurrence after surgery.

Determine the extent of cancer spread (staging): Tumor markers may help to determine the staging of cancer, which is very important for choosing the best treatment plan.

Estimating prognosis: Verifying the therapeutic effect.

1.3 Common Tumor Markers

According to different molecular types, tumor markers can be divided into:

(1) Enzyme or isoenzyme (PSA, PAP, NSE)

(2) Hormones (hCG, ACTH)

(3) Tumor embryonic antigen (AFP, CEA)

(4) Carbohydrates (CA 15-3, CA 19-9, CA125)

(5) Genes (BRCA1, K-ras)

The table below summarizes some common tumor markers that are closely related to various cancers:

Tumor maker	Cancer types	Use with Cancer
Alpha-fetoprotein (AFP)	Liver cancer, ovarian cancer and testicular cancer	help diagnose cancer; help stage a cancer; monitor cancer progress and treatment efficacy; monitor for cancer recurrence
Beta-2-microglobulin (B2M)	Multiple myeloma, chronic lymphocytic leukemia, and some lymphomas	monitor cancer progress and treatment efficacy; estimate prognosis
Carcinoembryonic antigen (CEA)	Colorectal cancer, lung cancer, gastric cancer, thyroid cancer, pancreatic cancer, breast cancer, and ovarian cancer	monitor cancer progress and treatment efficacy; monitor for cancer recurrence
CA-125	Ovarian cancer	help diagnose cancer; monitor cancer progress and treatment efficacy; monitor for cancer recurrence
CA 15-3 and CA 27-29	Breast cancer	monitor cancer progress and treatment efficacy; monitor for cancer recurrence
CA 19-9	Pancreas cancer, gallbladder cancer, cholangiocarcinoma, and gastric cancer	monitor cancer progress and treatment efficacy
Prostate-specific antigen (PSA)	Prostate cancer	help diagnose cancer; monitor cancer progress and treatment efficacy; monitor for cancer recurrence
Thyroglobulin	Thyroid cancer	monitor cancer progress and treatment efficacy; monitor for cancer recurrence

For more detailed information about tumor markers, please click: https://www.cusabio.com/c-20631.html

2. Importance of ELISA in Detection of Tumor Markers

ELISA (Enzyme-Linked Immunosorbent Assay) is a commonly used immunological detection technique that can be employed to detect specific proteins, antibodies, or other molecules in various biological samples. In the context of tumor marker detection, ELISA technology is widely applied and its importance is evident in the following aspects:

High sensitivity and specificity: ELISA technology exhibits high sensitivity and specificity in the detection of tumor markers. It can detect very low concentrations of markers while avoiding interference from other substances, thereby providing a fast, accurate, and reliable method for tumor marker detection.
Diverse sample types: ELISA technology can be applied to detect tumor markers in samples such as serum, plasma, cell culture supernatant, tissue homogenates, etc., accommodating the diverse biological distribution characteristics of different tumor markers.
Quantitative and semi-quantitative analysis: ELISA technology enables the quantitative measurement of tumor marker concentrations, aiding researchers in understanding the expression levels of markers under different conditions. It can also be used for semi-quantitative analysis, facilitating the comparison of relative differences between samples.
High throughput and ease of operation: ELISA technology is characterized by its simplicity, allowing for the simultaneous detection of multiple samples and enhancing experimental efficiency.
Disease research and mechanistic insights: ELISA technology plays a crucial role in unraveling the mechanisms of tumor development and investigating the associations between markers and diseases. It provides researchers with a valuable tool for gaining in-depth understanding of tumor biology.

3.CUSABIO Tumor Marker ELISA Kits

Code	Product Name	Detection Range	Target
CSB-E06873h	Human adrenocorticotropic hormone (ACTH) ELISA kit	12.5 pg/mL-200 pg/mL	ACTH
CSB-E06874m	Mouse adrenocorticotropic hormone (ACTH) ELISA kit	18.75 pg/mL-1200 pg/mL	ACTH
CSB-E06875r	Rat adrenocorticotropic hormone (ACTH) ELISA kit	1.25 pg/mL-50 pg/mL	ACTH
CSB-E12944p	Pig adrenocorticotropic hormone (ACTH) ELISA kit	6.25 pg/mL-100 pg/mL	ACTH
CSB-E14322B	Bovine adrenocorticotropic hormone (ACTH) ELISA kit	0.12 pg/mL-500 pg/mL	ACTH
CSB-E14373C	Chicken adrenocorticotropic hormone (ACTH) ELISA kit	0.25 pg/mL-50 pg/mL	ACTH
CSB-E15926Fh	Fish adrenocorticotropic hormone (ACTH) ELISA kit	75 pg/mL-1200 pg/mL	ACTH
CSB-EQ027618SH	Sheep adrenocorticotropic hormone (ACTH) ELISA kit	0.097 pg/mL-400 pg/mL	ACTH
CSB-E04770h	Human Alpha-fetoprotein,AFP ELISA Kit	1.563 ng/mL-100 ng/mL	AFP
CSB-E08282m	Mouse Alpha-fetoprotein,AFP ELISA Kit	1.23 ng/ml-900 ng/ml.	AFP
CSB-E08281r	Rat Alpha-fetoprotein,AFP ELISA Kit	15.6 pg/mL-1000 pg/mL	AFP
CSB-EL001421PI	Pig Alpha-fetoprotein(AFP) ELISA kit	3.12 ng/mL-200 ng/mL	AFP
CSB-E09058h	Human alpha-fetoprotein Lens culinaris agglutiin 3,AFP-L3 ELISA Kit	0.312 ng/mL-20 ng/mL	AFP-L3
CSB-E09160h	Human Placental alkaline phosphatase,PLAP ELISA Kit	84 pg/mL-2000 pg/mL	ALPP
CSB-E04883h	Human β2-microglobulin,BMG/β2-MG ELISA Kit	0.039 μg/mL-10 μg/mL	B2M
CSB-E11298r	Rat β2-microglobulin,BMG/β2-MG ELISA Kit	0.156 μg/mL-10 μg/mL	B2M
CSB-E13053m	Mouse β2-microglobulin,BMG/β2-MG ELISA Kit	0.156 μg/ml-10 μg/ml.	B2M
CSB-E13768c	Dog β2-microglobulin,BMG/β2-MG ELISA Kit	0.78 μg/mL-50 μg/mL	B2M
CSB-E08853h	Human B-cell leukemia/lymphoma 2,Bcl-2 ELISA Kit	0.9 ng/mL-60 ng/mL	BCL2
CSB-E08854r	Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit	0.312 ng/mL-20 ng/mL	BCL2

4. Additional Resources for Cancer Research

CD146, A Powerful Tumor Marker

CD20 Monoclonal Antibodies Drugs: There is an Explosion of New mAbs Against CD20!

An Overview of CD226 and Its Promising Role in Cancer Immunotherapy

CEACAM6: a Potent CEA Family Molecule, a New Tumor Marker or Anti-Cancer Target!

The Oncogene HER2: a New Target for Drug-Resistant Tumors

PD-1/PD-L1, What a Powerful Immune Checkpoint

PROM1 (CD133): A New Cell Surface Marker of Cancer Stem Cells (CSCs), A More Significant Target for Immunotherapy!

TMEFF2: a Tumor-Specific Methylated Biomarker, a Novel Target in Multiple Cancers