Recombinant Mouse CD27 antigen (Cd27), partial

1. CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells. PMID: 28588017
2. CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies. PMID: 28495792
3. CD27-dependent CD8(+) T cell priming and differentiation are shaped by the efficiency of NK responses to virus infection. PMID: 27798162
4. HSCs appear to maintain expression of CD27 after hematopoietic injury when Kit expression is downregulated. PMID: 25892186
5. Mature CD27low NK cells promote allograft survival under costimulatory blockade conditions by regulating alloreactive memory CD8+ T-cell responses in T-bet dependent manner. PMID: 25606781
6. identify an IL-17-dependent lymphoid/myeloid cross-talk involving CD27(-) gammadelta T cells and small peritoneal macrophages that promotes ovarian tumor cell growth and thus counteracts cancer immunosurveillance PMID: 25114209
7. memory CD8 T cells, generated through priming with CD27 agonists, proliferated more extensively than did 4-1BB-generated memory cells, but these cells failed to persist. PMID: 24860188
8. the central role played by CD27/70 during secondary CD8(+) T-cell activation to a peptide Ag, and identify sCD70 as an immunotherapeutic adjuvant for antitumor immunity. PMID: 24002868
9. under conditions of constitutive CD70 expression reflecting chronic immune activation, the CD27/CD70 system inhibits OC differentiation and favors DC differentiation PMID: 23832783
10. mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 induction by TCR and CD28 signals. PMID: 23547099
11. The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. PMID: 23159439
12. population of CD27(-) Th2 cells was significantly reduced by the anti-CD70 mAb treatment PMID: 22499851
13. The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions. PMID: 22781761
14. These data indicate that CD27/OX40 can serve the central function as signal 3 mediators, independent of IFN or IL-12, for the generation of CD8(+) T cell immune memory. PMID: 22178730
15. Data show that in a mouse model of chronic myelogenous leukemia, BCR/ABL+ leukemia stem and progenitor cells express CD27, and reveal a mechanism by which adaptive immunity contributes to leukemia progression. PMID: 22232214
16. CD27 is dispensable for the development of functional NK cells. However, upon stimulation of NK cells, CD27 displays an important role in their activation and functionality. PMID: 21283110
17. maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants PMID: 21763160
18. Our findings suggest that antigen persistence may determine the opposing effects of CD27/CD70 signaling on CD8 T cell responses during acute and chronic lymphocytic choriomeningitis virus infection of mice. PMID: 21507976
19. In this review, The CD27/CD70 axis has some unique properties that confer to it a crucial role as a regulator of immunity versus tolerance, favoring lymphocyte activation and survival and regulating immunity versus tolerance. PMID: 20699361
20. CD27 costimulation is not critical for the development of asthma in an experimental disease model PMID: 20600327
21. With strongly replicating (i.e., virulent) vaccinia virus, the TNFR family costimulatory receptors OX40 and CD27 were engaged and promoted the generation of high numbers of memory CD8+ T cells, which protected against a lethal virus challenge. PMID: 21183789
22. The PIQED region of the CD27 tail is involved in inhibition of terminal differentiation of B cells. PMID: 20974987
23. CD27 signaling upregulates antiapoptotic Bcl-2 family member Bcl-xL and supports generation of the CD8+ effector T cell pool, not only by counteracting apoptosis via Bcl-2 family members but also by directing expression of the Pim1 gene. PMID: 21048108
24. CD27 signals are required for the expansion of interferon-gamma-producing gammadelta27-positive cells. PMID: 21037088
25. LFA-1 signal defect-induced CD8(+) T cell apoptosis is associated with reduced CD27 costimulation and IL-15R survival signal, elucidating the molecular mechanism associated with LFA-1 signaling in effector and memory CD8(+) T cell survival PMID: 20569988
26. Continuous CD70-CD27 interaction resulted in strongly down-modulated CD27 expression on NK cells and gradually reduced absolute NK cell numbers. PMID: 20140903
27. CD27 signaling directs the IL-2 production that is reportedly essential to sustain survival of virus-specific CTLs in nonlymphoid tissue. PMID: 19955658
28. Data show that the short lifespan of T(H)17 cells was associated with small amounts of the antiapoptotic protein Bcl-2, the IL-15 receptor and the receptor CD27. PMID: 19935657
29. persistent delivery of costimulatory signals via CD27-CD70 interactions, as may occur during chronic active viral infections, can exhaust the T cell pool and is sufficient to induce lethal immunodeficiency PMID: 12469117
30. Signaling through CD27 during B cell priming inhibits primary antibody responses and induces differentiation into the memory lineage. PMID: 14634097
31. In addition to increasing the frequency of primed antigen-specific T cells, CD27 signaling during the primary response instills a program of differentiation that allows CD8+ T cells to overcome a state of unresponsiveness. PMID: 15128787
32. Stimulation of CD27 on B cells by CD28(+) Th cells accelerates germinal center formation, most likely by promoting centroblast expansion. In addition, CD27 on T cells can partially substitute for CD28 in supporting GC formation. PMID: 15187121
33. The novel costimulatory CD27-CD70 pathway is critical for CD28-independent effector/memory CD8+ alloreactive T cell activation in vivo. PMID: 15661893
34. Hematopoiesis is modulated by immune activation through interactions between CD27 and CD70. PMID: 15723067
35. Triggering of the costimulatory TNF receptor family member CD27 sensitizes T cells for CD95-induced apoptosis. PMID: 15879081
36. During influenza A virus infection, formation of the same CD8+ memory T cell pool as well as its capacity for secondary expansion depend on the complementary contributions of CD27, 4-1BB, and OX40. PMID: 16034107
37. purinergic receptor P2X stimulation by extracellular ATP results in rapid CD27 shedding via protease activation PMID: 16207496
38. Ligation of CD27 on memory cytotoxic T lymphocytes upon secondary antigen encounter increases clonal expansion and improves protection against re-infection with lymphocytic choriomeningitis virus. PMID: 16231287
39. CD27 is a key marker of the natural (NK) cell lineage, dividing the mature Mac-1high NK cell pool into two functionally distinct subsets. PMID: 16424180
40. Data show that during lymphocytic choriomeningitis virus infection, CD27 signaling on CD4+ T cells enhances the secretion of interferon-gamma and tumor necrosis factor-alpha. PMID: 16923852
41. CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation. PMID: 17159138
42. accumulation of mature CD27(low) CD4 T cells in the lungs correlates with the degree of protection against infection PMID: 17202360
43. Although CD27 is present on influenza virus-specific memory CD8-positive T cells, it is not required for the expansion of properly formed memory cells. PMID: 18292513
44. regulating CD27 expression on memory CTL is a novel mechanism how CD4+ T cells control CTL memory PMID: 18506879
45. CD27 instills specific functional activities into primed CD4+ T cells; functional impact of CD27 on CD4+ T cells is important for their CD8+ T cell helper activity, to endow memory CD8+ T cells with potential to accumulate after secondary challenge PMID: 18606659
46. A 4-stage model of NK-cell maturation CD11b(low)CD27(low) --> CD11b(low)CD27(high) --> CD11b(high)CD27(high) --> CD11b(high)CD27(low). PMID: 19234143
47. CD27 functions as a regulator of the differentiation of gammadelta T cells at least in part by inducing expression of the lymphotoxin-beta receptor and genes associated with trans-conditioning and interferon-gamma production. PMID: 19270712
48. CD27/CD70 interactions at the T-cell/DC interface prime CD8(+) T cells to become tumor-eradicating cytolytic effectors and memory cells PMID: 19279334
49. The CD27-CD70 costimulatory pathway plays a vital role in sustaining CD4+ T-cell mediated inflammation in colitis; blockade of the pathway leads directly to reduction in T cell numbers, less mucosal inflammation and fewer proinflammatory cytokines. PMID: 19525396
50. the CD70- and CD27-driven costimulatory axis may be involved in shutdown of B cell responses before clearance of Ag PMID: 19864607

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KEGG: mmu:21940

STRING: 10090.ENSMUSP00000032486

UniGene: Mm.367714