Nucleoprotein

What is nucleoprotein?

The nucleoprotein (NP), mentioned herein mainly refers to the nucleoprotein of human coronaviruses such as the recent emerged SARS-CoV-2, also called nucleocapsid protein (N), is a conjugated protein composed of the viral protein shell linked to single-stranded RNA. As a structural protein with no intrinsic enzymatic activity in SARS-CoV-2, N protein is a highly immunogenic and most abundant viral protein in infected cells.

What is the feature of the nucleoprotein structure?

The N protein of SARS-CoV-2 has been found to exist as a dimer in solution through CTD-CTD interaction. Weihong Zeng's structural characterization of recombinant full-length N protein predicted it possesses two well-folded domains: the N-terminal domain (NTD) and the C-terminal domain (CTD). Both of the two domains are rich in β-strands while CTD bears some short helices. The sequence of SARS-CoV-2 nucleoprotein is highly identical to that of SARS-CoV, and both of their two core domains and the linker are most conserved. Both NTD and CTD carrying positive charge on their surface may interpret the high binding-affinity between the N protein and non-specific nucleic acid.

What is the function of nucleoprotein?

The N protein is essential for the package of the positive-stranded viral genome RNA into a helical ribonucleocapsid (RNP). After infection, the N protein enters the host cell together with the viral RNA to facilitate its replication and then interacts with the viral genome and membrane protein M to assemble virus particles. Based on its immunogenicity, N protein is frequently used in vaccine development and serological assays.

Hot products of nucleoprotein:
Recombinant Human Novel Coronavirus Nucleoprotein (N) (N-terminal 6xHis-tagged) (CSB-EP3325GMY)
Recombinant Human Novel Coronavirus Nucleoprotein (N) (N-terminal 6xHis-PDI-tagged) (CSB-YP3325GMY)
Recombinant Human Novel Coronavirus Nucleoprotein (N) (CSB-MP3325GMY)
Recombinant Human Novel Coronavirus Nucleoprotein (N) (N-terminal 6xHis-sumostar-tagged) (CSB-YP3325GMYa4)
Recombinant Human Novel Coronavirus Nucleoprotein (N), partial (C-terminal 10xHis-tagged) (CSB-EP3325GMY1)
Recombinant Human Novel Coronavirus Nucleoprotein(N), Biotinylated (N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged) (CSB-EP3325GMY-B)
N Antibody (ELISA, GICA) (CSB-RA33255A0GMY)
N Antibody (ELISA, WB, GICA) (CSB-RA33255A1GMY)
N Antibody (ELISA) (CSB-RA33255A2GMY)
N Antibody, Biotin conjugated (ELISA) (CSB-RA33255D1GMY)
N Antibody, FITC conjugate (ELISA) (CSB-RA33255C1GMY)
N Antibody, HRP conjugated (ELISA) (CSB-RA33255B1GMY)
Human Novel Coronavirus Nucleoprotein (SARS-CoV-2 N) IgG Antibody ELISA Kit (CSB-EL3325HU)
Human Novel Coronavirus Nucleoprotein/Spike Glycoprotein S1 (SARS-CoV-2 N/S1) IgG Antibody ELISA Kit (CSB-EL3326HU)

The following Nucleoprotein reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

Nucleoprotein Antibodies

Nucleoprotein Proteins

Nucleoprotein ELISA Kits

Nucleoprotein Antibodies

Nucleoprotein Antibodies for Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)

Code	Product Name	Species Reactivity	Application
CSB-RA33255A0GMY	N Recombinant Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, GICA
CSB-RA33255A1GMY	N Recombinant Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, WB, GICA
CSB-RA33255B1GMY	N Recombinant Monoclonal Antibody, HRP conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-RA33255C1GMY	N Recombinant Monoclonal Antibody, FITC conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)
CSB-RA33255D1GMY	N Recombinant Monoclonal Antibody, Biotin conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA
CSB-RA33255A2GMY	N Recombinant Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, GICA
CSB-PA33254A0Rb	N Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	WB, ELISA
CSB-PA33254B0Rb	N Antibody, HRP conjugated	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	ELISA, WB
CSB-MA33255A1m	N Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	WB, ELISA
CSB-MA33255A0m	N Monoclonal Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	WB, ELISA
CSB-MA33255A2m	Nucleoprotein (NTD) Antibody	Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)	WB, ELISA

Nucleoprotein Antibodies for Bovine coronavirus (strain Mebus) (BCoV)(BCV)

Code	Product Name	Species Reactivity	Application
CSB-PA320768ZA01BJK	N Antibody	Bovine coronavirus	ELISA, WB (ensure identification of antigen)

Nucleoprotein Antibodies for Human coronavirus OC43 (HCoV-OC43)

Code	Product Name	Species Reactivity	Application
CSB-PA333798ZA01HIY	N Antibody	Human coronavirus OC43	ELISA, WB (ensure identification of antigen)

Nucleoprotein Antibodies for Human coronavirus 229E

Code	Product Name	Species Reactivity	Application
CSB-PA322753ZA01HIT	N Antibody	Human coronavirus 229E	ELISA, WB

Nucleoprotein Proteins

Nucleoprotein Proteins for Bovine coronavirus (strain Mebus) (BCoV)(BCV)

Code	Product Name	Source
CSB-YP320768BJK CSB-BP320768BJK CSB-MP320768BJK CSB-EP320768BJK-B	Recombinant Bovine coronavirus Nucleoprotein (N)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP320768BJK	Recombinant Bovine coronavirus Nucleoprotein (N)	E.coli

Nucleoprotein Proteins for Human coronavirus 229E (HCoV-229E)

Code	Product Name	Source
CSB-YP322753HIT CSB-EP322753HIT-B	Recombinant Human coronavirus 229E Nucleoprotein (N)	Yeast In Vivo Biotinylation in E.coli
CSB-EP322753HIT	Recombinant Human coronavirus 229E Nucleoprotein (N)	E.coli
CSB-EP322753HITc7	Recombinant Human coronavirus 229E Nucleoprotein (N)	E.coli
CSB-BP322753HIT	Recombinant Human coronavirus 229E Nucleoprotein (N)	Baculovirus
CSB-MP322753HIT	Recombinant Human coronavirus 229E Nucleoprotein (N)	Mammalian cell
CSB-MP322753HITc7	Recombinant Human coronavirus 229E Nucleoprotein (N)	Mammalian cell

Nucleoprotein Proteins for Human coronavirus OC43 (HCoV-OC43)

Code	Product Name	Source
CSB-YP333798HIY CSB-EP333798HIY-B	Recombinant Human coronavirus OC43 Nucleoprotein (N)	Yeast In Vivo Biotinylation in E.coli
CSB-EP333798HIY	Recombinant Human coronavirus OC43 Nucleoprotein (N)	E.coli
CSB-BP333798HIY	Recombinant Human coronavirus OC43 Nucleoprotein (N)	Baculovirus
CSB-MP333798HIY	Recombinant Human coronavirus OC43 Nucleoprotein (N)	Mammalian cell
CSB-MP333798HIYd9	Recombinant Human coronavirus OC43 Nucleoprotein (N)	Mammalian cell

Nucleoprotein Proteins for Human coronavirus NL63 (HCoV-NL63)

Code	Product Name	Source
CSB-YP744150HIX CSB-MP744150HIX CSB-EP744150HIX-B	Recombinant Human coronavirus NL63 Nucleoprotein (N)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-BP744150HIX	Recombinant Human coronavirus NL63 Nucleoprotein (N)	Baculovirus
CSB-EP744150HIX	Recombinant Human coronavirus NL63 Nucleoprotein (N)	E.coli

Nucleoprotein Proteins for Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)

Code	Product Name	Source
CSB-MP3325GMY	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N)	Mammalian cell
CSB-EP3325GMY	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (Active)	E.coli
CSB-YP3325GMY	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N)	Yeast
CSB-YP3325GMYa4	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N)	Yeast
CSB-EP3325GMY-B	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N),Biotinylated	E.coli
CSB-EP3325GMY1	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), partial	E.coli
CSB-EP3325GMY(M2)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (T205I) (Active)	E.coli
CSB-EP3325GMY(M3)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (P80R) (Active)	E.coli
CSB-EP3325GMY(M4)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (P13L) (Active)	E.coli
CSB-EP3325GMY(M5)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (D103Y) (Active)	E.coli
CSB-EP3325GMY(M9)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (L230F) (Active)	E.coli
CSB-EP3325GMY(M10)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (I292T) (Active)	E.coli
CSB-EP3325GMY(M11)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (Q384H) (Active)	E.coli
CSB-EP3325GMY(M12)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (R203K,G204R) (Active)	E.coli
CSB-EP3325GMY(M1)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (D3L,R203K,G204R,S235F) (Active)	E.coli
CSB-EP3325GMY(M13)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (R203M,D377Y) (Active)	E.coli
CSB-EP3325GMY(M14)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (D63G,R203M,D377Y) (Active)	E.coli
CSB-EP3325GMY(M8)	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N) (S202N) (Active)	E.coli
CSB-EP3325GMY2-B	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), partial,Biotinylated	E.coli
CSB-EP3325GMY2a0	Recombinant Severe acute respiratory syndrome coronavirus 2 Nucleoprotein (N), partial	E.coli

Nucleoprotein ELISA Kit

Nucleoprotein ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL3325HU	Human SARS-CoV-2 N IgG Antibody ELISA Kit	serum, plasma

Popular Pathways

Apoptosis

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Hippo signaling pathway

TGF-beta signaling pathway

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