The nucleoprotein (NP), mentioned herein mainly refers to the nucleoprotein of human coronaviruses such as the recent emerged SARS-CoV-2, also called nucleocapsid protein (N), is a conjugated protein composed of the viral protein shell linked to single-stranded RNA. As a structural protein with no intrinsic enzymatic activity in SARS-CoV-2, N protein is a highly immunogenic and most abundant viral protein in infected cells.
The N protein of SARS-CoV-2 has been found to exist as a dimer in solution through CTD-CTD interaction. Weihong Zeng's structural characterization of recombinant full-length N protein predicted it possesses two well-folded domains: the N-terminal domain (NTD) and the C-terminal domain (CTD). Both of the two domains are rich in β-strands while CTD bears some short helices. The sequence of SARS-CoV-2 nucleoprotein is highly identical to that of SARS-CoV, and both of their two core domains and the linker are most conserved. Both NTD and CTD carrying positive charge on their surface may interpret the high binding-affinity between the N protein and non-specific nucleic acid.
The N protein is essential for the package of the positive-stranded viral genome RNA into a helical ribonucleocapsid (RNP). After infection, the N protein enters the host cell together with the viral RNA to facilitate its replication and then interacts with the viral genome and membrane protein M to assemble virus particles. Based on its immunogenicity, N protein is frequently used in vaccine development and serological assays.
Hot products of nucleoprotein:
Recombinant Human Novel Coronavirus Nucleoprotein (N) (N-terminal 6xHis-tagged) (CSB-EP3325GMY)
Recombinant Human Novel Coronavirus Nucleoprotein (N) (N-terminal 6xHis-PDI-tagged) (CSB-YP3325GMY)
Recombinant Human Novel Coronavirus Nucleoprotein (N) (CSB-MP3325GMY)
Recombinant Human Novel Coronavirus Nucleoprotein (N) (N-terminal 6xHis-sumostar-tagged) (CSB-YP3325GMYa4)
Recombinant Human Novel Coronavirus Nucleoprotein (N), partial (C-terminal 10xHis-tagged) (CSB-EP3325GMY1)
Recombinant Human Novel Coronavirus Nucleoprotein(N), Biotinylated (N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged) (CSB-EP3325GMY-B)
N Antibody (ELISA, GICA) (CSB-RA33255A0GMY)
N Antibody (ELISA, WB, GICA) (CSB-RA33255A1GMY)
N Antibody (ELISA) (CSB-RA33255A2GMY)
N Antibody, Biotin conjugated (ELISA) (CSB-RA33255D1GMY)
N Antibody, FITC conjugate (ELISA) (CSB-RA33255C1GMY)
N Antibody, HRP conjugated (ELISA) (CSB-RA33255B1GMY)
Human Novel Coronavirus Nucleoprotein (SARS-CoV-2 N) IgG Antibody ELISA Kit (CSB-EL3325HU)
Human Novel Coronavirus Nucleoprotein/Spike Glycoprotein S1 (SARS-CoV-2 N/S1) IgG Antibody ELISA Kit (CSB-EL3326HU)
The following Nucleoprotein reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Nucleoprotein Antibodies for Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-RA33255A0GMY | N Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA |
CSB-RA33255A1GMY | N Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, WB, GICA |
CSB-RA33255B1GMY | N Recombinant Monoclonal Antibody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-RA33255C1GMY | N Recombinant Monoclonal Antibody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | |
CSB-RA33255D1GMY | N Recombinant Monoclonal Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
CSB-RA33255A2GMY | N Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA |
CSB-PA33254A0Rb | N Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | WB, ELISA |
CSB-PA33254B0Rb | N Antibody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, WB |
CSB-MA33255A1m | N Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | WB, ELISA |
CSB-MA33255A0m | N Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | WB, ELISA |
CSB-MA33255A2m | Nucleoprotein (NTD) Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | WB, ELISA |
CSB-EAP33255A1 | SARS-CoV-2 N Antibody Pair 1 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-EAP33255A2 | SARS-CoV-2 N Antibody Pair 2 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-EAP33255A3 | SARS-CoV-2 N Antibody Pair 3 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
CSB-EAP33255A4 | SARS-CoV-2 N Antibody Pair 4 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
Nucleoprotein Antibodies for Bovine coronavirus (strain Mebus) (BCoV)(BCV)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA320768ZA01BJK | N Antibody | Bovine coronavirus | ELISA, WB (ensure identification of antigen) |
Nucleoprotein Antibodies for Human coronavirus OC43 (HCoV-OC43)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA333798ZA01HIY | N Antibody | Human coronavirus OC43 | ELISA, WB (ensure identification of antigen) |
Nucleoprotein Antibodies for Human coronavirus 229E
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA322753ZA01HIT | N Antibody | Human coronavirus 229E | ELISA, WB |
Nucleoprotein Proteins for Bovine coronavirus (strain Mebus) (BCoV)(BCV)
Code | Product Name | Source |
---|---|---|
CSB-YP320768BJK CSB-BP320768BJK CSB-MP320768BJK CSB-EP320768BJK-B |
Recombinant Bovine coronavirus Nucleoprotein (N) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP320768BJK | Recombinant Bovine coronavirus Nucleoprotein (N) | E.coli |
Nucleoprotein Proteins for Human coronavirus 229E (HCoV-229E)
Code | Product Name | Source |
---|---|---|
CSB-YP322753HIT CSB-EP322753HIT-B |
Recombinant Human coronavirus 229E Nucleoprotein (N) | Yeast In Vivo Biotinylation in E.coli |
CSB-EP322753HIT | Recombinant Human coronavirus 229E Nucleoprotein (N) | E.coli |
CSB-EP322753HITc7 | Recombinant Human coronavirus 229E Nucleoprotein (N) | E.coli |
CSB-BP322753HIT | Recombinant Human coronavirus 229E Nucleoprotein (N) | Baculovirus |
CSB-MP322753HIT | Recombinant Human coronavirus 229E Nucleoprotein (N) | Mammalian cell |
CSB-MP322753HITc7 | Recombinant Human coronavirus 229E Nucleoprotein (N) | Mammalian cell |
Nucleoprotein Proteins for Human coronavirus OC43 (HCoV-OC43)
Code | Product Name | Source |
---|---|---|
CSB-YP333798HIY CSB-EP333798HIY-B |
Recombinant Human coronavirus OC43 Nucleoprotein (N) | Yeast In Vivo Biotinylation in E.coli |
CSB-EP333798HIY | Recombinant Human coronavirus OC43 Nucleoprotein (N) | E.coli |
CSB-BP333798HIY | Recombinant Human coronavirus OC43 Nucleoprotein (N) | Baculovirus |
CSB-MP333798HIY | Recombinant Human coronavirus OC43 Nucleoprotein (N) | Mammalian cell |
CSB-MP333798HIYd9 | Recombinant Human coronavirus OC43 Nucleoprotein (N) | Mammalian cell |
Nucleoprotein Proteins for Human coronavirus NL63 (HCoV-NL63)
Code | Product Name | Source |
---|---|---|
CSB-YP744150HIX CSB-MP744150HIX CSB-EP744150HIX-B |
Recombinant Human coronavirus NL63 Nucleoprotein (N) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-BP744150HIX | Recombinant Human coronavirus NL63 Nucleoprotein (N) | Baculovirus |
CSB-EP744150HIX | Recombinant Human coronavirus NL63 Nucleoprotein (N) | E.coli |
Nucleoprotein Proteins for Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Nucleoprotein ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL3325HU | Human SARS-CoV-2 N IgG Antibody ELISA Kit | serum, plasma |