Mhc Antibody

1. Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension. PMID: 27183005
2. We conclude that MHC isoforms can alter FSA and hence cyclical power generation but that isoforms can only endow a muscle type with moderate FSA Highly SA muscle types, such as IFM, likely use a different or additional mechanism. PMID: 27881413
3. Introduction of a mutation (R759E) in the converter domain inhibits the steady-state ATPase of myosin S1, whereas an additional mutation in the relay domain (N509K) is able to restore the ATPase. PMID: 26586917
4. The vector of cell movement is regulated by localised epidermal growth factor (EGF) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation. PMID: 25460353
5. Using transgenic techniques the study shows that an embryonic myosin converter domain influences Drosophila indirect flight muscle stretch activation, power generation and flight. PMID: 24115062
6. Data indicate that disruption of the relay-converter domain interface leads to complete absence of myosin ATPase activity. PMID: 24627474
7. The abnormalities observed in myosin function and muscle ultrastructure likely contribute to muscle weakness observed in our flies and patients. PMID: 22496423
8. The data indicated that interactions of the relay and converter of myosin heavy chain during the contractile cycle are key to myosin-isoform-specific kinetic and mechanical functions. PMID: 22226837
9. These results provide the first mutational evidence that intramolecular signaling between the relay loop and converter domain of mhc is critical for myosin function both in vitro and in muscle. PMID: 20362584
10. function of different myosin isoforms PMID: 11901423
11. myosin rod protein has an active function to modulate the contractile activity of muscles in which it is expressed PMID: 12927543
12. Single point mutations in the ATP binding/hydrolysis domain of Mhc and lead to degeneration of the flight muscles. PMID: 15051736
13. the N-terminal region is important in tuning myosin kinetics to match muscle speed for optimal locomotory performance PMID: 15345559
14. the exon 7 domain participates in the regulation of the attachment of myosin to actin in order to fine-tune the physiological properties of Drosophila myosin isoforms PMID: 16154586
15. exon 7 plays a substantial role in establishing fiber speed and flight performance, and the limiting step that sets ATPase rate in Drosophila myosin has little to no direct influence in setting fmax for fast muscle fiber types PMID: 16399836
16. Myosin II (zipper) and fringe have roles in planar polarization of the denticle field in the Drosophila embryo PMID: 16890930
17. Study shows that a 2.6kb fragment of the muscle myosin heavy-chain gene of Drosophila melanogaster (containing 458 base pairs of upstream sequence, the first exon, the first intron and the beginning of the second exon) drives expression in all muscles. PMID: 17194628
18. Alternative hinges are important in dictating the distinct functional properties of myosin isoforms and the muscles in which they are expressed. PMID: 17316684

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KEGG: dme:Dmel_CG17927

STRING: 7227.FBpp0080452

UniGene: Dm.2761