Code | CSB-YP013218MO |
Size | Pls inquire |
Source | Yeast |
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Code | CSB-EP013218MO-B |
Size | Pls inquire |
Source | E.coli |
Conjugate | Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. |
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Code | CSB-BP013218MO |
Size | Pls inquire |
Source | Baculovirus |
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Code | CSB-MP013218MO |
Size | Pls inquire |
Source | Mammalian cell |
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Description |
Recombinant Mouse Lymphotoxin-alpha (Lta) is a partial length protein expressed with an N-terminal His-tagged or Tag-Free. Its expression region corresponds to 34-202aa of mouse Lta protein. Its purity was determined by SDS-PAGE and reached up to 85%. This recombinant Lta protein may be used to synthesize antibodies against Lta or on the studies of Lta-associated signal transduction.
Lta is a cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Accumulating evidences have showed that expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies. |
Purity | >85% (SDS-PAGE) |
Target Names | Lta |
Uniprot No. | P09225 |
Alternative Names | Lta; Tnfb; Tnfsf1; Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1 |
Species | Mus musculus (Mouse) |
Expression Region | 34-202 |
Target Protein Sequence | LSGVRFS AARTAHPLPQ KHLTHGILKP AAHLVGYPSK QNSLLWRAST DRAFLRHGFS LSNNSLLIPT SGLYFVYSQV VFSGESCSPR AIPTPIYLAH EVQLFSSQYP FHVPLLSAQK SVYPGLQGPW VRSMYQGAVF LLSKGDQLST HTDGISHLHF SPSSVFFGAF AL |
Protein Length | Full Length of Mature Protein |
Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If
you have specified tag type, please tell us and we will develop the specified tag preferentially.
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Form |
Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. |
Buffer before Lyophilization | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Troubleshooting and FAQs |
Protein FAQs |
Storage Condition | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Shelf Life | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
Lead Time | Delivery time
may differ from different purchasing way or location, please kindly consult your local distributors
for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Datasheet | Please contact us to get it. |
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Please provide the following information regarding CSB-EP013218MO (all expression systems)
1) Can this product be administered to mice?
2) Would you be able to provide this product lyophilized? Based on question 1, do you not recommend lyophilizing this product as it may lower activity?
3) We would like to know the standard and low endotoxin level would be for this product.
Function |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
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Gene References into Functions |
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Subcellular Location | Secreted. Membrane. |
Protein Families | Tumor necrosis factor family |
Database Links |
KEGG: mmu:16992 STRING: 10090.ENSMUSP00000025266 UniGene: Mm.87787 |