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| Code | CSB-MP007479HU |
| Product Type | Other |
| Size | US$258 |
| Uniprot No. | P00533 |
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| Protocols | Biological Activity Assay |
| Storage Buffer | Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose,pH 8.0 |
| Alias | Recommended name:Epidermal growth factor receptor EC=2.7.10.1 Alternative name(s):Proto-oncogene c-ErbB-1 Receptor tyrosine-protein kinase erbB-1 |
| Species | Homo sapiens (Human) |
| Biological_Activity | Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind human EGFR antibody, the EC50 of human EGFR protein is 2.867-3.571 ng/ml. |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU/ug as determined by LAL method. |
| Sequence | LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPS |
| Research Area | Cancer |
| Source | Mammalian cell |
| Gene Names | EGFR |
| Expression Region | 25-645aa |
| Tag Info | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Mol. Weight | 73.6 kDa |
| Protein Description | Extracellular Domain |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity). |
| Involvement in disease | Lung cancer (LNCR); Inflammatory skin and bowel disease, neonatal, 2 (NISBD2) |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Nucleus membrane, Single-pass type I membrane protein, Endosome, Endosome membrane, Nucleus |
| Protein Families | Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily |
| Tissue Specificity | Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. |
| Database Links |
HGNC: 3236 OMIM: 131550 KEGG: hsa:1956 STRING: 9606.ENSP00000275493 UniGene: Hs.488293 |
| Pathway |
Calcium signaling pathway
ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Adherens junction Ras signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway Endocytosis |
EGFR Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA10279C0Rb | EGFR Antibody, FITC conjugated | Human | ELISA |
| CSB-PA10279A0Rb | EGFR Antibody | Human | ELISA, IHC, IF |
| CSB-PA10279D0Rb | EGFR Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA10279B0Rb | EGFR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005571LA01HU | EGFR Antibody | Human | ELISA, WB, IF |
EGFR Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA007479GA01HU | EGFR Antibody | Human | ELISA,WB |
| CSB-PA209840 | Phospho-EGFR (Ser1070) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA069395 | Phospho-EGFR (Tyr1092) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA561961 | Phospho-EGFR (Thr678) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA979756 | Phospho-EGFR (Thr693) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA277676 | Phospho-EGFR (Tyr1172) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA049634 | Phospho-EGFR (Tyr1197) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA184845 | Phospho-EGFR (Tyr869) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA938612 | Phospho-EGFR (Tyr1110) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA183869 | Phospho-EGFR (Tyr1197) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA174357 | EGFR (Ab-1070) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA953009 | EGFR (Ab-1092) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA929356 | EGFR (Ab-678) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA179555 | EGFR (Ab-693) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA033139 | EGFR (Ab-1172) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA911813 | EGFR (Ab-1197) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA877124 | EGFR (Ab-869) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA111241 | EGFR (Ab-1110) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA956575 | EGFR (Ab-1197) Goat Polyclonal Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA559519 | Phospho-EGFR (Tyr1016) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA189998 | Phospho-EGFR (Ser695) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA119181 | Phospho-EGFR (Ser1071) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA957122 | Phospho-EGFR (Ser1026) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA579851 | EGFR (Ab-1172) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA079221 | EGFR (Ab-1026) Antibody | Human | ELISA,WB |
| CSB-PA294390 | EGFR (Ab-1071) Antibody | Human | ELISA,WB |
| CSB-PA005571LB01HU | EGFR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005571LC01HU | EGFR Antibody, FITC conjugated | Human | ELISA |
| CSB-PA005571LD01HU | EGFR Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA000199 | EGFR Monoclonal Antibody | Human | ELISA,WB,IHC,IF |
| CSB-MA000293 | EGFR Monoclonal Antibody | Human | ELISA,WB |
| CSB-PA000514 | Phospho-EGFR (T693) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA000515 | Phospho-EGFR (Y1092) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA000516 | Phospho-EGFR (Y1110) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA000517 | Phospho-EGFR (Y1197) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA000664 | Phospho-EGFR (T678) Antibody | Human,Mouse,Rat,Monkey | WB,IF,ELISA |
| CSB-PA002264 | EGFR Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA002267 | EGFR Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA002273 | EGFR Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA002275 | EGFR Antibody | Human,Mouse | WB,ELISA |
| CSB-PA002281 | EGFR Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA007950 | Phospho-EGFR (S1070) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA007951 | Phospho-EGFR (Y1172) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007952 | Phospho-EGFR (Y869) Antibody | Human,Mouse,Rat | WB,IF,ELISA |
| CSB-PA007953 | Phospho-EGFR (Y1069) Antibody | Human,Mouse,Rat,Monkey | WB,ELISA |
| CSB-PA007954 | Phospho-EGFR (S695) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007966 | Phospho-EGFR (S1026) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007968 | Phospho-EGFR (S1071) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007969 | Phospho-EGFR (Y1016) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA007971 | EGFR Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007973 | EGFR Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007976 | EGFR Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA007977 | EGFR Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA007978 | EGFR Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA162597 | EGFR Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA007479A1092phHU | Phospho-EGFR (Y1092) Antibody | Human | ELISA, WB |
| CSB-RA007479A1068phHU | Phospho-EGFR (Y1068) Antibody | Human | ELISA, WB |
EGFR Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP007479HU CSB-EP007479HU CSB-BP007479HU |
Recombinant Human Epidermal growth factor receptor(EGFR),partial | Yeast E.coli Baculovirus |
| CSB-EP007479HU3 | Recombinant Human Epidermal growth factor receptor(EGFR),partial | E.coli |
EGFR ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E12124h | Human epidermal growth factor receptor,EGFR ELISA Kit | serum, plasma, tissue homogenates | 0.019 ng/mL |
Recombinant Human Methylenetetrahydrofolate reductase(MTHFR)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Chitinase-3-like protein 1(CHI3L1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Sulfotransferase 1A1(Sult1a1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human LIM domain transcription factor LMO4(LMO4)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Heat shock protein HSP 90-beta(HSP90AB1)
Express system: E.coli
Species: Homo sapiens (Human)
