LYZ Antibody

Code CSB-PA013283ZA01CH
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Product Details

Full Product Name Rabbit anti-Gallus gallus (Chicken) LYZ Polyclonal antibody
Uniprot No. P00698
Target Names LYZ
Alternative Names Lysozyme C (EC (1,4-beta-N-acetylmuramidase C) (Allergen Gal d IV) (allergen Gal d 4), LYZ
Raised in Rabbit
Species Reactivity Gallus gallus
Immunogen Recombinant Gallus gallus LYZ protein
Immunogen Species Gallus gallus (Chicken)
Conjugate Non-conjugate
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

(From Uniprot)
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.
Gene References into Functions
  1. NG and NR inhibited the enzymatic activity of Hen Egg White Lysozyme (HEWL) and exhibited their affinity for the active site of HEWL. PMID: 29145059
  2. Molecular docking results suggested the location of vandetanib (VDB) binding site near the LYZ active site while molecular dynamics simulation results suggested stability of VDB-LYZ complex. PMID: 28843881
  3. Specific structural changes constitute the first steps in lysozyme unfolding by urea. PMID: 27573790
  4. Molecular dynamics (MD) simulation results demonstrate that the "hard protein" lysozyme retains much of its secondary structure during adsorption, whereas BSA loses it almost completely. BSA has a considerably larger adsorption energy compared to that of lysozyme, which does not scale with chain length. Desorption simulations are carried out using classical steered MD. PMID: 27421144
  5. The ability of an anion to slow down the water dynamics around lysozyme was found to have the following order: SCN- > Cl- > H2PO4- > NO3- approximately SO42-. This result indicates that the effects of anions on the dynamics of water around the lysozyme molecule are the opposite of those for bulk water. PMID: 27193313
  6. Protein microcrystals magnetically aligned in D2O hydrogels were subjected to neutron diffraction measurements, and reflections were observed for the first time to a resolution of 3.4 A from lysozyme microcrystals ( approximately 10 x 10 x 50 microm). PMID: 27377379
  7. Here, a single nanocrystal with a diffracting volume of only 0.14 microm(3), i.e. no more than 6 x 10(5) unit cells, provided sufficient information to determine the structure of a rare dimeric polymorph of hen egg-white lysozyme by electron crystallography. PMID: 28876237
  8. Solutions of lysozyme in heavy water were studied by small-angle neutron scattering at concentrations of 40, 20 and 10 mg ml(-1) with and without the addition of precipitant, and at temperatures of 10, 20 and 30 degrees C. In addition to the expected protein monomers, dimeric and octameric species were identified in solutions at the maximum concentration and close to the optimal conditions for crystallization. PMID: 28695859
  9. The enzyme activity of LYZ was inhibited by the addition of copper with catalytic residues Glu 35 and Asp 52 locating at the binding sites. This study helps to elucidate the molecular mechanism of the interaction between copper and lysozyme and provides reference for toxicological studies of copper. PMID: 27089183
  10. At neutral pH, lysozyme retains its native conformation between 0 and 8 M urea over the entire range of temperatures studied. PMID: 27933780
  11. Data show that hen lysozyme aggregates faster than the human lysozyme. PMID: 27825804
  12. Different C-type lysozyme gene haplotypes are associated with egg hatchability and survival in Rhode Island Red layer chickens PMID: 27478034
  13. Drospirenone had different effects on the local conformation of HSA and LYZ molecules. PMID: 26448295
  14. At micro-second and coarser temporal resolutions, free energy landscape of hen egg white lysozyme exhibits hub-like topology with crystal structures occupying the dominant structural ensemble. PMID: 26057625
  15. Data indicate that lysozyme significantly enhances the dewaterability of biosludge. PMID: 25462773
  16. Data show that copper(II) inhibits self-association of hen egg white lysozyme (HEWL) at pH 12.75 both at 37 and 65 degrees C. PMID: 24806136
  17. Under high pressure, the crystal structure of the enzyme undergoes several local and global changes accompanied by changes in hydration structure. PMID: 25849385
  18. Structure of hen egg-white lysozyme determined from single shots of trapped microcrystals. PMID: 25849403
  19. Egg white-lysozyme protein structure and stability revealed by X-ray crystallography. PMID: 25521080
  20. Underdamped delocalized vibrational modes in the terahertz frequency domain are identified and shown to blue-shift and strengthen upon LYZ-triacetylchitotriose binding. PMID: 24893252
  21. Data suggest that stabilization of lysozyme by mono- and oligo-saccharides can be accounted for by simplified statistical-thermodynamic model considering volume exclusion deriving from steric repulsion between enzyme and saccharides. PMID: 26000826
  22. These results show that pressure suppresses protein nucleation, aggregation, and finally crystallization in supersaturated condensed lysozyme solutions. PMID: 25494777
  23. The study explores fingerprinting the tertiary structure of electroadsorbed lysozyme at soft interfaces by electrostatic spray ionization spectrometry PMID: 25156670
  24. Aberrant disulfide bonds in non-amyloidogenic proteins (like HEWL), may strengthen non-covalent intermolecular forces among monomers and promote their aggregation. PMID: 24551048
  25. This study compared the influence of Cu(II) ions and pH of the environment on the molecular structure of the native protein and its fibrils. PMID: 23786978
  26. lysozyme C structure determined by X-ray crystallography method PMID: 23295480
  27. This study analyzes binding structures of complexes of lysozyme and N-acetyl-beta-glucosamine trisaccharide, (NAG)(3). PMID: 23109228
  28. The results of the three simulations show that the structural properties of fully thionated LYZ clearly differ from those of the native protein, while for partly thionated LYZ they only changed slightly compared with native LYZ. PMID: 22653637
  29. Small-angle x-ray scattering studies on dense lysozyme solutions of high ionic strength as a function of temperature and pressure, are reported. PMID: 22713580
  30. Both backbone amide and side chain methyl bond vectors in LYZ are relatively rigid in both the apo and chitotriose-bound states. PMID: 22593013
  31. The tri-N-acetylglucosamine-bound state of the enzyme is less hydrated, more rigid, and less dynamic compared to the unbound state. PMID: 22732010
  32. The study provides a quantitative description of the solvation properties of lysozyme in water/ethanol mixtures, which has been obtained by a simultaneous analysis of small-angle neutron scattering and differential scanning calorimetry experiments. PMID: 22225188
  33. The study applied a protein mapping method to nine structures of hen egg-white lysozyme, and idenified ligand binding sites. PMID: 22092261
  34. investigation of protein conformation/stability of lysozyme by comparison with analogs with varying degrees of ester linkages replacing amide/peptide linkages using molecular dynamics simulations PMID: 22093234
  35. The study presents conformational responses of hen egg white lysozyme in the tetragonal crystal by X-ray diffraction experiments using a humidity-control apparatus, which provided air flow of 20-98%rh at 298 K. PMID: 21802827
  36. The interaction between gold nanorods and lysozyme has been monitored using spectroscopic techniques. PMID: 21729718
  37. These results demonstrate the enhanced chaperone activity of modified beta-casein and its protective effects on lysozyme refolding. PMID: 21802443
  38. The orientation of lysozyme adsorbed to a negatively charged ligand surface was predicted by a rigid and a flexible model. PMID: 21689536
  39. The whole hydration sites (HS) of lysozyme are composed of 195 single HSs and 38 clustered ones (CHS), and divided into 231 external HSs (EHS) and 2 internal ones (IHS). PMID: 21435773
  40. The NMR results indicate that low-lying excited state conformers of hen lysozyme are characterized by slowly fluctuating local conformations around these cavities, attributed to the opportunities for water molecules to penetrate into the cavities. PMID: 21367514
  41. fibril formation by hen egg white lysozyme PMID: 21483680
  42. Data revealed that lysozyme with higher SDS concentrations showed superior thermodynamic stabilities over the ones with no or lower levels of SDS. PMID: 20674294
  43. The reversible thermal unfolding of hen egg white lysozyme, was examined. PMID: 20923660
  44. The interactions of lysozyme with caffeine (Caf), theophylline (Tph) and theobromine (Tbr) were investigated. PMID: 19823947
  45. Results describe the size, shape, structure, and interactions of lysozyme in the ternary system lysozyme/DMSO/water at low protein concentrations. PMID: 20731407
  46. Utilizing fluorescence correlation spectroscopy high spatial resolution of about the laser wavelength used, the molecular dynamics close to crystal surfaces was investigated for both tetragonal single crystals and needlelike spherulites. PMID: 20831338
  47. Two model proteins, lysozyme and thaumatin, were used under unique flow conditions to differentially probe protein crystal nucleation and growth. PMID: 20713010
  48. Single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to hen egg lysozyme His15 in two significantly populated rotamer conformations. PMID: 20449250
  49. Acetylation of the lysine residues promoted amyloid formation, resulting in more pronounced fibrils and a dramatic decline in the nucleation time. In contrast, citraconylation produced the opposite effect. PMID: 19945549
  50. The obtained data suggested that LSZ embedment within the H(II) mesophase improved its thermal stability by hampering its helical structure destruction, apparently due to hydrogen bonding of the protein with monoolein polar heads. PMID: 19836212

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Subcellular Location Secreted.
Protein Families Glycosyl hydrolase 22 family
Tissue Specificity In the egg white and polymorphonuclear leukocytes.
Database Links

KEGG: gga:396218

STRING: 9031.ENSGALP00000016177

UniGene: Gga.713

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