Human Complement C2(C2) ELISA kit

Code CSB-EL003658HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
complement component 2
Alternative Names
ARMD14 ELISA Kit; C2 ELISA Kit; C3/C5 convertase ELISA Kit; CO2 ELISA Kit; CO2_HUMAN ELISA Kit; Complement C2 ELISA Kit; Complement C2a fragment ELISA Kit; complement component 2 ELISA Kit; DKFZp779M0311 ELISA Kit
Abbreviation
C2
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
15.6 ng/mL-250 ng/mL
Sensitivity
15.6 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Competitive
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human complement component 2 (C2) ELISA Kit was designed for the quantitative measurement of Human complement component 2 (C2) protein in serum, plasma, tissue homogenates_x005f_x000D_. It is a Competitive ELISA kit, its detection range is 15.6 ng/mL-250 ng/mL and the sensitivity is 15.6 ng/mL.

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Target Background

Function
(From Uniprot)
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Gene References into Functions
  1. Vag8 binding to human C1-inhibitor (C1-inh) interferes with the binding of C1-inh to C1s, C1r and MASP-2, resulting in the release of active proteases that subsequently cleave C2 and C4 away from the bacterial surface. PMID: 28742139
  2. Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases. PMID: 27252379
  3. The rs2844455 A allele of C2 is a risk factor for systemic lupus erythematosus development in a Chinese population, whereas the G allele might be a protective factor. PMID: 26176736
  4. our data indicate that C2 rs547154 polymorphism plays a protective role in the development of PCV. PMID: 25732348
  5. Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. PMID: 24983375
  6. These overall results suggest a lack of strong association with the C2 and C7 gene polymorphisms to the susceptibility of systemic lupus erythematosus in the Malaysian population. PMID: 21881993
  7. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
  8. CFH (RS1061170), C2 (RS547154), OR CFB (RS438999) was not associated with early or late AMD. PMID: 23060141
  9. These data suggest that patients with C2 deficiency are at increased risk of Streptococcus pyogenes infections. PMID: 20417301
  10. C2 microheterogeneity and histocompatibility antigens Class I were studied in an Austrian population. PMID: 12823772
  11. study of the formation of high affinity C5 convertase of the classical pathway of complement PMID: 12878586
  12. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 PMID: 16670774
  13. a weaker, independent protective effect exists for complement component 2 in age related macular degeneration. PMID: 17576744
  14. These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections. PMID: 18541650
  15. Study provides insights into the genetic pathogenesis of AMD, and C2 has been shown as one of the five genes independently involved in progression from intermediate disease to advanced disease in which blindness is frequent. PMID: 19015224
  16. Upon cleavage by C1s, C2a domains undergo conformational rotation while bound to C4b and the released C2b domains may remain folded together as seen in the intact protein. PMID: 19237749

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Involvement in disease
Complement component 2 deficiency (C2D)
Subcellular Location
Secreted.
Protein Families
Peptidase S1 family
Database Links

HGNC: 1248

OMIM: 217000

KEGG: hsa:717

STRING: 9606.ENSP00000299367

UniGene: Hs.408903

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