cry Antibody

1. photo-induced electron transfer reactions in Drosophila melanogaster cryptochrome are indeed influenced by magnetic fields of a few millitesla. PMID: 28176875
2. Substitutions of four key Trp residues to redox-active tyrosine and redox-inactive phenylalanine tune the light sensitivity of dCRY photoreduction, conformational activation, cellular stability, and targeted degradation of the clock protein timeless PMID: 29581265
3. we identify the circadian blue-light photoreceptor CRYPTOCHROME as a molecular regulator of Prolonged Morning Wakefulness (PMW), and propose a model in which the Drosophila nervous system integrates information encoding temperature, light, and time to dynamically control when sleep is initiated. Our results provide a platform to investigate how environmental inputs co-ordinately regulate sleep plasticity. PMID: 28084307
4. The findings of this article for the first time define CRY expression in Drosophila peripheral tissues and reveal that CRY acts together with K(+) channels to maintain passive membrane properties in a non-clock-containing peripheral tissue independent of light. PMID: 28781048
5. Changes in active site histidine hydrogen bonding trigger cryptochrome activation. PMID: 27551082
6. CRY is not stabilized by interaction with the kinase Shaggy (SGG), the GSK-3 beta fly orthologue. PMID: 26741981
7. our studies provided novel evidence that the circadian clock gene, dCry, plays an essential role in heart morphogenesis and function. PMID: 26348211
8. Using time-resolved and steady-state optical spectroscopy, we studied the mechanism of light-induced radical-pair formation and decay, and the photoreduction of the FAD cofactor. PMID: 25879256
9. The results of this study concluded that the E oscillators are the targets of light input via CRY and the visual system and are required for normal light entrainment. PMID: 25878285
10. The Cry leucine-histidine substitution is common in Drosophila, with both alleles at intermediate frequencies across 27 populations surveyed in Europe, irrespective of latitude. PMID: 24475129
11. Both oxidized and reduced forms of dCRY are capable of photosignaling. PMID: 24379403
12. Flavin reduction activates Drosophila cryptochrome. PMID: 24297896
13. Our findings indicate that CRY compensates for limited light sensitivity in vivo by photon integration over extraordinarily long times, and point to select circadian pacemaker neurons as having important roles. PMID: 23874218
14. dampens temperature-induced PERIOD oscillations in dorsal clock neurons PMID: 23333312
15. Study reports crystal structures of full-length dCRY, a dCRY loop deletion construct, and the photolyase homology region of mouse CRY1 (mCRY1). PMID: 23746849
16. Data indicate that wild-type flies show greatly enhanced magnitude of phase shift, but cryptochrome (CRY)-less flies seem impaired in the ability to integrate duration of the light pulse in a wild-type manner. PMID: 22476772
17. Study reports that increased nighttime activity of Clk mutants is mediated by high levels of the circadian photoreceptor CRYPTOCHROME (CRY) in large ventral lateral neurons (l-LN(v)s). PMID: 22581798
18. Drosophila photolyases contain F0 as the second chromophore; within the limitation of the current assay, neither plant nor animal cryptochromes seem to carry a second chromophore. PMID: 22175817
19. 2.3-A resolution crystal structure of Drosophila CRY with an intact C terminus PMID: 22080955
20. Data show that CRY is a key component for the preferential entrainment to light. PMID: 21135155
21. study shows the CRY-mediated light response requires a flavin redox-based mechanism and depends on potassium channel conductance but is independent of the classical circadian CRY-TIMELESS interaction PMID: 21385718
22. CRY's photolyase homology domain is sufficient for light detection and phototransduction, whereas the carboxyl-terminal domain regulates CRY stability, CRY-TIM interaction, and circadian photosensitivity PMID: 15178801
23. Cryb mutant flies exhibited free-running rhythms with two rhythmic components. Drosophila locomotor rhythms may be driven by two separate PER-dependent clocks, responding differentially to constant light. PMID: 15183277
24. show a strong interaction between Veela and cryptochrome genetic variants, demonstrating that the Jetlag, Timeless, and Cry proteins function in the same pathway PMID: 17068124
25. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons PMID: 18399544
26. CRY is not a core component, but an exclusive photoreceptor in the cuticle deposition rhythm. PMID: 18539772
27. the first genetic evidence for a Cry-based magnetosensitive system in any animal PMID: 18641630
28. Spatial and cricadian regulation of cry in Drosophila are reported. PMID: 18663236
29. cry is expressed in a subset of circadian oscillator neurons in the Drosophila CNS. PMID: 18663237
30. After illumination, Jetlag protein induces massive degradation of Cry as part of the resetting process of the circadian clock in reaction to light. PMID: 19185492
31. These results suggest that cry, Rh1, Rh5 and Rh6 are essential for circadian photoentrainment to green and yellow light. PMID: 19398933

Show More

Hide All

KEGG: dme:Dmel_CG3772

STRING: 7227.FBpp0083150

UniGene: Dm.4579