Infectious Disease Research

Chikungunya Virus (CHIKV) Research

Explore key Chikungunya virus proteins and host-response targets for studies of viral entry, replication, antibody responses and virus–host interactions.

E1 / E2 Capsid nsP1–nsP4 Antiviral Research Immune Response

Explore CHIKV Products Custom Solutions

Chikungunya virus CHIKV structure and major research targets

CHIKV structure schematic based on Yap et al., 2017.

CHIKV Overview

Chikungunya Virus

Chikungunya virus (CHIKV) is an enveloped, positive-sense single-stranded RNA virus belonging to the Alphavirus genus of the Togaviridae family. It is primarily transmitted by Aedes mosquitoes. CHIKV research covers viral entry and replication, virus–host interactions, host immune responses, neutralizing antibodies, vaccine research and antiviral discovery.

Structural Proteins

CHIKV structural proteins participate in viral particle formation, host-cell attachment, membrane fusion and virion assembly.

E2 – receptor interaction and antibody recognition
E1 – membrane fusion
Capsid – viral RNA packaging
E3 / 6K – virion maturation and assembly

Nonstructural Proteins

The four major CHIKV nonstructural proteins form the core machinery required for viral RNA replication.

nsP1 – RNA capping and membrane association
nsP2 – protease and helicase-associated functions
nsP3 – replication and host interactions
nsP4 – RNA-dependent RNA polymerase

Key Research Targets

Choose CHIKV Targets by Research Question

Different CHIKV proteins are involved in distinct stages of viral infection and replication. Selecting targets according to the research question can help identify appropriate recombinant proteins, antibodies or customized reagents.

E1 / E2

Viral Entry & Antibody Research

Relevant to viral attachment, membrane fusion, antibody recognition, neutralization, epitope mapping and vaccine-related research.

Capsid

Virus Assembly

Relevant to viral RNA packaging, nucleocapsid formation, virion assembly and antigen research.

nsP1 / nsP2

Replication & Antiviral Research

Important for research into RNA replication, nonstructural polyprotein processing and viral enzyme functions.

nsP3 / nsP4

Replication & Host Interaction

Relevant to replication-complex biology, host-factor interactions and viral RNA synthesis.

Research Applications

Major CHIKV Research Areas

Viral Entry & Antibody Research

E1 and E2 are major CHIKV envelope proteins and key targets for investigating viral entry and antibody responses.

Virus–receptor interactions
Neutralizing antibody research
Epitope mapping
Antibody binding studies
Vaccine antigen research

Key targets: E1, E2

Viral Replication & Antiviral Research

nsP1–nsP4 form the CHIKV replication machinery and provide important targets for mechanistic and antiviral research.

Viral RNA replication
Polyprotein processing
Viral enzyme research
Small-molecule screening
Antiviral target research

Key targets: nsP1, nsP2, nsP3, nsP4

Virus–Host & Immune Response Research

CHIKV interacts with cellular proteins and activates innate and adaptive immune pathways during infection.

Virus–host protein interactions
Interferon signaling
Cytokine responses
Innate immunity
Inflammatory mechanisms

Key targets: G3BP1/2, IRF3/7, interferons and inflammatory cytokines

CUSABIO Products

CHIKV Research Products

Explore CUSABIO recombinant proteins and antibodies currently available for Chikungunya virus research. For CHIKV targets or constructs not available in the catalog, customized recombinant protein production is also available.

CHIKV Recombinant Proteins

Product	Code	Target	Species / Strain	Expression System
Recombinant Chikungunya virus Non-structural polyprotein, Partial	CSB-EP810351CJAT	Polyprotein P1234	Chikungunya virus (strain S27-African prototype) (CHIKV)	E.coli
Recombinant Chikungunya virus Non-structural polyprotein, partial	CSB-EP726396CGAS	Polyprotein P1234	Chikungunya virus (strain 37997) (CHIKV)	E.coli
Recombinant Chikungunya virus Structural polyprotein, partial	CSB-EP713427CFAR1	Structural polyprotein	Chikungunya virus (strain Nagpur) (CHIKV)	E.coli
Recombinant Chikungunya virus Structural polyprotein, partial	CSB-EP733443CGAS1	Structural polyprotein	Chikungunya virus (strain 37997) (CHIKV)	E.coli
Recombinant Chikungunya virus Structural polyprotein, partial	CSB-EP809064CJAT1	Structural polyprotein	Chikungunya virus (strain S27-African prototype) (CHIKV)	E.coli

CHIKV Antibodies

Product	Code	Target	Species / Strain	Tested Applications
Polyprotein P1234 Antibody	CSB-PA810351ZA01CJAT	Polyprotein P1234	Chikungunya virus (strain S27-African prototype)	ELISA, WB

Looking for E1, E2, Capsid or Another CHIKV Protein?

CHIKV studies may require a specific viral strain, protein domain, fragment, mutation or expression format that is not currently available as a standard catalog product.

Send us your target sequence and research requirements. CUSABIO can evaluate a customized recombinant protein production solution.

Request a Custom CHIKV Protein

Host Response Research

Explore CHIKV-Related Host Targets

CHIKV research can extend beyond viral proteins to cellular factors, innate immune signaling and inflammatory mediators involved in the host response to infection.

Virus–Host Interaction

Host proteins associated with viral replication, replication-complex formation and cellular stress responses.

G3BP1 G3BP2

Innate Antiviral Signaling

Targets associated with viral recognition and type I interferon responses.

TLR7 IRF3 IRF7 IFN-α IFN-β

Cytokine & Inflammation Research

Immune mediators frequently investigated in studies of CHIKV-associated inflammatory responses.

IL-6 TNF-α IL-1β CXCL10 CCL2

Custom Research Solutions

Can't Find the CHIKV Protein You Need?

Different CHIKV studies may require specific viral strains, sequences, fragments, mutations or expression formats. CUSABIO provides custom recombinant protein production for specialized infectious disease research.

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Customizable Options

Different viral strains or sequences
Full-length proteins or specific fragments
Mutant proteins
Different fusion tags
E. coli expression
Yeast expression
Insect-cell expression
Mammalian-cell expression

FAQ

Frequently Asked Questions

Which CHIKV proteins are commonly studied in antibody research?

E1 and E2 are major CHIKV envelope proteins and are important targets for research into viral entry, antibody recognition, neutralization, epitope mapping and vaccine-related mechanisms.

Which CHIKV proteins are important for viral replication research?

nsP1, nsP2, nsP3 and nsP4 form the core CHIKV replication machinery. These proteins are widely studied in relation to RNA synthesis, polyprotein processing, replication-complex formation and virus–host interactions.

Does CUSABIO currently provide CHIKV research products?

CUSABIO currently provides a recombinant CHIKV nonstructural polyprotein product and a Polyprotein P1234 antibody. Researchers can also submit other CHIKV targets for customized recombinant protein production.

Can CUSABIO produce customized E1, E2 or other CHIKV proteins?

Yes. Researchers can submit the required target sequence, viral strain, fragment, tag and expression requirements for custom recombinant protein production evaluation.

Find the Right Products for Your CHIKV Research

Explore currently available CHIKV recombinant proteins and antibodies, or send us your target sequence for a customized research solution.

Explore CHIKV Products Request a Custom Solution

For Research Use Only. This page is intended to provide information about CHIKV research targets and related research products. It does not constitute experimental-design advice. Experimental design, conditions and data interpretation should be selected and validated according to the specific research objective, model and sample type.

References

Yap ML, Klose T, Urakami A, et al. Structural studies of Chikungunya virus maturation. Proceedings of the National Academy of Sciences (PNAS). 2017;114(52):13703–13707.

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