ply Antibody

Code CSB-PA312102ZA01FNF
Size US$299
Image
  • Western Blot
    Positive WB detected in: recombinant protein
    All lanes: ply Antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 66 kDa
    Observed band size: 66 kDa
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Product Details

Uniprot No.
Target Names
ply
Alternative Names
Pneumolysin (Thiol-activated cytolysin), ply
Species Reactivity
Streptococcus pneumoniae serotype 2
Immunogen
Recombinant Streptococcus pneumoniae serotype 2 ply protein (2-471aa)
Immunogen Species
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The ply polyclonal antibody production involves initiating an immune response in a rabbit using a recombinant Streptococcus pneumoniae serotype 2 ply protein fragment (encompassing amino acids 2-471) as the immunogen. Serum collected from the rabbit contains polyclonal antibodies. These antibodies are subsequently purified through affinity chromatography. Extensive validation procedures confirm the antibody's specificity for Streptococcus pneumoniae serotype 2 ply protein. This ply antibody is suitable for use in ELISA and WB assays.

The major virulence factor pneumolysin (ply), produced by Streptococcus pneumoniae serotype 2, functions as a pore-forming toxin. Ply forms pores within the cell membrane, which aid in the dissemination of bacteria and augment the disruption of cellular barriers and the demise of host cells, thereby playing a role in the development of the disease. It also exerts potent pro-inflammatory effects and participates in the invasion by breaching the epithelial layers.

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Target Background

Function
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol-containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.
Subcellular Location
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein Families
Thiol-activated cytolysin family
Database Links
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