ply Antibody

Datasheet

Code	CSB-PA312102ZA01FNF
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: ply Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66 kDa Observed band size: 66 kDa
The Latest Promotion
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q04IN8

Target Names

ply

Alternative Names

Pneumolysin (Thiol-activated cytolysin), ply

Species Reactivity

Streptococcus pneumoniae serotype 2

Immunogen

Recombinant Streptococcus pneumoniae serotype 2 ply protein (2-471aa)

Immunogen Species

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The ply polyclonal antibody production involves initiating an immune response in a rabbit using a recombinant Streptococcus pneumoniae serotype 2 ply protein fragment (encompassing amino acids 2-471) as the immunogen. Serum collected from the rabbit contains polyclonal antibodies. These antibodies are subsequently purified through affinity chromatography. Extensive validation procedures confirm the antibody's specificity for Streptococcus pneumoniae serotype 2 ply protein. This ply antibody is suitable for use in ELISA and WB assays.

The major virulence factor pneumolysin (ply), produced by Streptococcus pneumoniae serotype 2, functions as a pore-forming toxin. Ply forms pores within the cell membrane, which aid in the dissemination of bacteria and augment the disruption of cellular barriers and the demise of host cells, thereby playing a role in the development of the disease. It also exerts potent pro-inflammatory effects and participates in the invasion by breaching the epithelial layers.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol-containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.

Subcellular Location

Secreted. Host cell membrane; Multi-pass membrane protein.

Protein Families

Thiol-activated cytolysin family

Database Links

KEGG: spd:SPD_1726

STRING: 373153.SPD_1726

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

TWIK2 channel mediates inflammation, study finds Does Antibody-dependent Enhancement Occur in SARS-CoV-2 Infection? Streptococcus pneumoniae, a Primary Cause of Pneumonia CCR8: a Specific Marker on Tregs Cells, the Next Promising Candidate for Antitumor Drugs! How to Properly Reconstitute Lyophilized Proteins? TFPI: a Natural Anticoagulant Protein, Future Therapies for Hemophilia Chemokine Receptor CCR4: the Key Role of CCR4+Treg Cells in Cancer Immunotherapy Proteolysis Targeting Chimera (PROTAC): A RSPO1: The key factor determining "battle of the sexes " is “favored” in the culture of organoids? TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors! The Collection of Progress of Anti-GPCR Antibody Drugs With the High Potential in Cancer Immunotherapy, CD40 Is Triggering Attention CD73, What a Powerful Therapy Target in Tumor Immune Exploring Biological Landscape of Cervical Cancer: A Comprehensive Overview for Researchers CLDN4: A Potential Prognostic Indicator and Therapeutic Target in Tumors！ CD19-The Most Popular Target with CAR T-Cell Therapy GFRAL: A Promising Metabolic Target for Improving Obesity and Anorexia/Cachexia DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors! Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis! Leukemia, Why is it So Common? The Overview of Cell Viability The Metabolic Phenotype of Tumor-Associated Macrophages in the Tumor Microenvironment CEACAM5: A Promising Member of CEACAM Family, A Potential Target for ADC Drug Research! The Meaning of Irregular Antibody Screening Exploring Neurodegeneration: A Comprehensive Guide for Researchers The Recently Emerged New Swine Influenza Virus -- G4 EA-H1N1 Tools You Need For Fundamental Research TCGA Database- A Good Partner of Researchers About Thyroid Tumor, This Information You Must Know! What Essential Biological Knowledge is Needed for Hepatocellular Carcinoma Research? GPCR Drugs Discovery TMPRSS2, an Activator for SARS-CoV-2 Invasion What Is an Antibody? LY6G6D (LY6-G): A New Member of Lymphocyte Antigen-6 Family Holds Big Opportunities in Bispecific Antibody for CRC Treatment! How to choose a suitable expression vector? 11 tips for choosing your right ELISA kit CUSABIO's Five Expression Systems Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research! FAP may be a drug target for pancreatic cancer PD-1/PD-L1, What a Powerful Immune Checkpoint Itaconate is a negative regulator of inflammation The Overview of Growth Factor The Overview of Interferon How to Choose an Antibody for Scientific Research? Production of Recombinant Protein The overview of Wnt signaling pathway The overview of TGF-β signaling pathway The Encyclopedia of Common Virus CLDN3: Another Tight Junction Protein or New Drug Target, Interest in CLDN Family is Growing Fast! Oncostatin M (OSM): A Member of IL-6 Cytokine Family, An Underestimated Player in Future Targeted Therapies? In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your Research Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

ply Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background