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The ply polyclonal antibody production involves initiating an immune response in a rabbit using a recombinant Streptococcus pneumoniae serotype 2 ply protein fragment (encompassing amino acids 2-471) as the immunogen. Serum collected from the rabbit contains polyclonal antibodies. These antibodies are subsequently purified through affinity chromatography. Extensive validation procedures confirm the antibody's specificity for Streptococcus pneumoniae serotype 2 ply protein. This ply antibody is suitable for use in ELISA and WB assays.
The major virulence factor pneumolysin (ply), produced by Streptococcus pneumoniae serotype 2, functions as a pore-forming toxin. Ply forms pores within the cell membrane, which aid in the dissemination of bacteria and augment the disruption of cellular barriers and the demise of host cells, thereby playing a role in the development of the disease. It also exerts potent pro-inflammatory effects and participates in the invasion by breaching the epithelial layers.
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