FES Antibody

Code CSB-PA002518
Size US$100
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  • Western Blot analysis of HuvEc cells using Fes Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
FES
Alternative Names
c-fes/fps protein antibody; cFES antibody; Feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog antibody; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami antibody; Feline sarcoma oncogene antibody; Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody; fes antibody; FES proto oncogene, tyrosine kinase antibody; FES_HUMAN antibody; FPS antibody; Oncogene FES antibody; Oncogene FES feline sarcoma virus antibody; P93c fes antibody; Proto oncogene tyrosine protein kinase Fes/Fps antibody; Proto-oncogene c-Fes antibody; Proto-oncogene c-Fps antibody; proto-oncogene tyrosine-protein kinase Fes/Fps antibody; Tyrosine-protein kinase Fes/Fps antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human Fes.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Gene References into Functions
  1. analysis of the JAK-Fes-phospholipase D signaling pathway that is enhanced in highly proliferative breast cancer cells PMID: 23404507
  2. c-fes gene expression was found in myeloid leukemias, whereas low or no expression in lymphocytic leukemias. PMID: 20030920
  3. FES kinase is a mediator of wild-type KIT signalling implicated in cell migration. PMID: 20117079
  4. Fes naturally adopts an inactive conformation in vivo, and maintenance of the inactive structure requires the coiled-coil and SH2 domains. PMID: 12653561
  5. Fes transduces inductive signals for terminal macrophage and granulocyte differentiation, and this biological activity is mediated through the activation of lineage-specific transcription factors. PMID: 15003822
  6. FPS mediates enhanced sensitization to VEGF and PDGF signaling in ECs; this hypersensitization contributes to excessive angiogenic signaling and underlies the observed hypervascular phenotype of human myristoylated FPS expressed in transgenic mice. PMID: 15099290
  7. c-Fes is a regulator of the tubulin cytoskeleton and may contribute to Fes-induced morphological changes in myeloid hematopoietic and neuronal cells PMID: 15485904
  8. NMR assignment of the SH2 domain PMID: 15630569
  9. PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells PMID: 15713745
  10. NMR analysis of Src homology 2 domain from the human feline sarcoma oncogene Fes PMID: 15929003
  11. FES has a growth suppressive function in colorectal neoplasms. PMID: 16455651
  12. A novel Fes-KAP-1 interaction is reported, suggesting a dual role for KAP-1 as both a Fes activator and downstream effector. PMID: 16792528
  13. These novel results indicate the involvement of Fes in VEGF-A-induced cellular responses by cultured endothelial cells. PMID: 17521372
  14. shows a major function of FES downstream of activated KIT receptor and thereby points to FES as a novel target in KIT-related pathologi PMID: 17595334
  15. Ezrin/Fes interaction at cell-cell contacts plays an essential role in hepatocyte growth factor-induced cell scattering and implicates Fes in the cross-talk between cell-cell and cell-matrix adhesion. PMID: 18046454
  16. The SH2 and catalytic domains of active Fes and Abl pro-oncogenic kinases form integrated structures essential for effective tyrosine kinase signaling. PMID: 18775312
  17. study shows Fes phosphorylates C-terminal tyrosine residues in HS1 implicated in actin stabilization; coordinated action of F-BAR & SH2 domains of Fes allow for coupling to FcepsilonRI signaling & potential regulation of actin reorganization in mast cells PMID: 19001085
  18. Study of promoter methylation as important mechanism responsible for downregulation of FES gene expression in colorectal cancer cells. Treatment with DNA methyltransferase inhibitor resulted in expression of functional FES transcripts in CRC cell lines. PMID: 19051325
  19. Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of renal carcinoma. PMID: 19082481
  20. c-Fes oligomerization is independent of activation; data suggest that conformational changes, rather than oligomerization, govern c-Fes kinase activation and downstream signaling in vivo. PMID: 19382747
  21. FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells PMID: 19885553

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Involvement in disease
Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation of the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as activated kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells (PubMed:20111072). Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid differentiation (PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or absent in samples from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses anchorage-independent growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and might be a predictor of recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma cells (PubMed:19082481).
Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Fes/fps subfamily
Tissue Specificity
Widely expressed. Detected in adult colon epithelium (at protein level). Expressed in melanocytes (at protein level).
Database Links

HGNC: 3657

OMIM: 190030

KEGG: hsa:2242

STRING: 9606.ENSP00000331504

UniGene: Hs.7636

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