Autoimmune Disease Series--

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by aberrant immune system activation, multi-organ involvement, and autoantibody production. Its etiology involves multifactorial contributions from genetic, environmental, and hormonal factors. Core pathological mechanisms include dysregulated activation of B cells leading to autoantibody production, T cell dysfunction, aberrant activation of interferon signaling pathways, and complement system dysregulation. Conventional therapies rely on glucocorticoids and immunosuppressants but carry risks of infection and organ toxicity, underscoring the need for targeted precision therapies.

Recent advances in SLE drug development focus on modulating key immune checkpoints. Belimumab, the first FDA-approved B cell activating factor (BAFF) inhibitor, blocks BAFF/APRIL signaling to suppress B cell maturation. Telitacicept, a recombinant fusion protein, neutralizes both BAFF and a proliferation-inducing ligand (APRIL), enhancing B cell depletion. Anifrolumab targets the type I interferon receptor, blocking excessive interferon signaling activation. JAK inhibitors such as baricitinib regulate T cell and plasma cell functions by inhibiting the JAK-STAT pathway. Upadacitinib, a selective JAK1 inhibitor, further optimizes efficacy-safety profiles. Emerging approaches include belimumab's new indication targeting complement C1s and CAR-T cell therapy demonstrating promise in refractory SLE, marking a shift from single-target to multi-pathway combination strategies.

CUSABIO specializes in providing high-quality research tools including proteins, antibodies, and ELISA kits. We have curated a series of popular SLE research targets and related reagents for scientific investigators:

Systemic lupus erythematosus Drug Targets Related Products

● Target Proteins

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

CD40
CSB-MP004936HU1

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CD40LG
CSB-MP004937HU3

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC₅₀ is 2.353-3.232 ng/ml.

CD79A
CSB-MP004957HU1

Measured by its binding ability in a functional ELISA. Immobilized Human CD79A at 2 μg/ml can bind Anti-CD79A recombinant antibody(CSB-RA004957MA1HU). The EC₅₀ is 1.521-1.700 ng/mL.

CLEC4C
CSB-MP855470HUh7

Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody(CSB-RA855470MA1HU)，the EC50 is 7.658-12.99 ng/mL.

IL17A
CSB-BP624104HU(M)

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC₅₀ is 1.818-2.170 ng/mL.

IL2
CSB-MP011629HU

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA(CSB-MP011649HU3) at 2μg/mL can bind Human IL2，the EC₅₀ is 0.4992 to 0.6269 ng/mL.

IL6
CSB-YP011664HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 58 - 295 pg/mL.

Target	Product Name	Source	Tag Info	Product Code
Alb	Recombinant Mouse Serum albumin (Alb)	Baculovirus	C-terminal 9xHis-tagged	CSB-BP001561MO
ALB	Recombinant Dog Serum albumin (ALB)	E.coli	N-terminal 6xHis-tagged	CSB-EP001561DO
ALB	Recombinant Macaca fascicularis albumin (ALB)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP001561MOV
ALB	Recombinant Macaca fascicularis albumin (ALB)	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP001561MOV
ALB	Recombinant Dog Serum albumin (ALB)	Yeast	N-terminal 6xHis-tagged	CSB-YP001561DO
Alb	Recombinant Mouse Albumin (Alb)	Yeast	N-terminal 6xHis-tagged	CSB-YP001561MO
ALB	Recombinant Macaca fascicularis albumin (ALB)	Yeast	N-terminal 6xHis-tagged	CSB-YP001561MOV
ALB	Recombinant Bovine Serum albumin (ALB)	Yeast	C-terminal 6xHis-Myc-tagged	CSB-YP001561BO
ALB	Recombinant Bos taurus Albumin (ALB)	Baculovirus	C-terminal 6xHis-tagged	CSB-BP001561BO
Alb	Recombinant Rat Serum albumin (Alb), Biotinylated	E.coli	N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged	CSB-EP001561RA-B
ALB	Recombinant Chicken Serum albumin (ALB), partial	Yeast	C-terminal 6xHis-tagged	CSB-YP001561CH
ALB	Recombinant Chicken Albumin (ALB), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP001561CH
Alb	Recombinant Rat Serum albumin (Alb)	E.coli	N-terminal 6xHis-tagged and C-terminal Avi-tagged	CSB-EP001561RA
ALB	Recombinant Dog Serum albumin (ALB), Biotinylated	E.coli	N-terminal 6xHis-Avi-tagged	CSB-EP001561DOg2-B
C1QA	Recombinant Human Complement C1q subcomponent subunit A (C1QA)	Baculovirus	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-BP003637HU
C1QA	Recombinant Human Complement C1q subcomponent subunit A (C1QA)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003637HU
C1QA	Recombinant Human Complement C1q subcomponent subunit A (C1QA)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003637HUb1
C1qa	Recombinant Mouse Complement C1q subcomponent subunit A (C1qa)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003637MO
C1qa	Recombinant Mouse Complement C1q subcomponent subunit A (C1qa)	E.coli	N-terminal 6xHis-tagged	CSB-EP003637MOa0
C1qa	Recombinant Rat Complement C1q subcomponent subunit A (C1qa)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003637RA

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● Antibodies

C3 Recombinant Monoclonal Antibody
CSB-RA303909A0HU

Tested Applications:
ELISA, WB, IHC, FC

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

CD8A Recombinant Monoclonal Antibody
CSB-RA934881A0HU

Tested Applications:
ELISA, WB, IHC, IP

IL1B Recombinant Monoclonal Antibody
CSB-RA011614MA1HU

Tested Applications:
ELISA, IHC, FC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
ALB	ALB Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA264109A0HU
C3	C3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-RA303909A0HU
C3	C3 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA699863A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA004888MA1HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA004888MA2HU
CD22	CD22 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA962691A0HU
CD38	CD38 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA796695A0HU
CD4	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA004935A0HU
CD40	CD40 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA004936MA1HU
CD79A	CD79A Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004957MA1HU
CD8A	CD8A Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA934881A0HU
CLEC4C	CLEC4C Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA855470MA1HU
CRP	CRP Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA988767A0HU
IL10	IL10 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011580A0HU
IL10	IL10 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA011580MA1HU
IL17A	IL17A Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA624104MA1HU
IL1B	IL1B Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA011614MA1HU
IL6	IL6 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011664MA1HU
IL6	IL6 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA011664MA2HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
TLR7	TLR7 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA556665A0HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
ALB	ALB Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA076752
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
CD38	CD38 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA785760
CD4	CD4 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000228
CD4	CD4 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA043428
CD4	CD4 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA981329
CD4	CD4 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA124048
CD4	CD4 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA260243
CD4	CD4 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA570802
CD4	CD4 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA783233
CD4	CD4 Monoclonal Antibody,PE Conjugated	Mouse	ELISA, FC	CSB-MA084552
CD79A	CD79A Monoclonal Antibody	Human	ELISA, IHC	CSB-MA961575
CD8A	CD8A Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA255790

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- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
ALB	ALB Antibody	Canine	ELISA	CSB-PA00260E1Rb
ALB	ALB Antibody, HRP conjugated	Canine	ELISA	CSB-PA00260F1Rb
ALB	ALB Antibody, FITC conjugated	Canine		CSB-PA00260G1Rb
ALB	ALB Antibody, Biotin conjugated	Canine	ELISA	CSB-PA00260H1Rb
ALB	ALB Antibody	Bovine	ELISA	CSB-PA00950E1Rb
ALB	ALB Antibody, HRP conjugated	Bovine	ELISA	CSB-PA00950F1Rb
ALB	ALB Antibody, FITC conjugated	Bovine		CSB-PA00950G1Rb
ALB	ALB Antibody, Biotin conjugated	Bovine	ELISA	CSB-PA00950H1Rb
ALB	ALB Antibody	Human, Mouse	ELISA, WB, IHC, IF	CSB-PA001561LA01HU
ALB	ALB Antibody, HRP conjugated	Human	ELISA	CSB-PA001561LB01HU
ALB	ALB Antibody, FITC conjugated	Human		CSB-PA001561LC01HU
Alb	Alb Antibody	Rat	ELISA, WB	CSB-PA001561LA01RA
ALB	ALB Antibody	Human, Mouse, Rat	ELISA, IHC	CSB-PA001561GA01HU
ALB	ALB Antibody	Human	ELISA, WB, IHC	CSB-PA079344
ALB	BSA Antibody	Bovine	ELISA, WB	CSB-PA592874
ALB	BSA Antibody	Bovine	ELISA, WB	CSB-PA272395
BTG3	BTG3 Antibody	Human	ELISA, IHC	CSB-PA969912
C1QA	C1QA Antibody	Human	ELISA, IHC, IF	CSB-PA003637LA01HU
C1QA	C1QA Antibody, HRP conjugated	Human	ELISA	CSB-PA003637LB01HU
C1QA	C1QA Antibody, FITC conjugated	Human		CSB-PA003637LC01HU

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● ELISA Kits

Rat Interferon γ,IFN-γ ELISA Kit
CSB-E04579r-IS

Human Interleukin 10,IL-10 ELISA Kit
CSB-E04593h-IS

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit
CSB-E12819h-IS

Mouse Interleukin 1β,IL-1β ELISA Kit
CSB-E08054m-IS

Target	Product Name	Sample Types	Detection Range	Code
ALB	Dog Albumin(Alb) ELISA Kit	serum, plasma, tissue homogenates	0.273 μg/mL-35 μg/mL	CSB-E15757c
ALB	Mouse Albumin (Alb)ELISA Kit	serum, plasma, tissue homogenates	0.781 μg/mL-200 μg/mL	CSB-E13878m
ALB	Pig Albumin (Alb) ELISA Kit	serum, plasma, urine	0.03 μg/mL-7000 μg/mL	CSB-E16207p
ALB	Sheep Albumin (Alb)ELISA Kit	serum, plasma, cell culture supernates, urine, tissue homogenates	5.47 μg/ml-350 μg/ml	CSB-E15839Sh
ALB	Horse Albumin(Alb) ELISA Kit	serum, plasma	1.25 μg/mL-80 μg/mL	CSB-E16205Hs
ALB	Bovine Albumin(Alb) ELISA kit	serum, plasma, tissue homogenates	0.313 μg/mL-80 μg/mL	CSB-E08664b
ALB	Goat Albumin (Alb)ELISA Kit	serum, plasma, tissue homogenates	0.17 μg/mL-350 μg/mL	CSB-E15758G
ALB	Rabbit Albumin(Alb) ELISA Kit	serum, plasma, urine	0.273 μg/mL-70 μg/mL	CSB-E16204Rb
ALB	Guinea Pig Albumin(Alb) ELISA kit	serum, plasma, tissue homogenates	0.156 μg/mL-10 μg/mL	CSB-E15765Gp
C1QA	Human Complement C1q subcomponent subunit A(C1QA) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	9.38 ng/mL-600 ng/mL	CSB-EL003637HU
C1QA	Mouse Complement C1q subcomponent subunit A(C1QA) ELISA kit	serum, plasma, tissue homogenates	0.156 μg/mL-10 μg/mL	CSB-EL003637MO
C3	Human Complement 3,C3 ELISA Kit	serum, plasma, cell culture supernates, urine, saliva	4.7 ng/mL-300 ng/mL	CSB-E08665h
C3	Rat Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL-40 μg/mL	CSB-E08666r
C3	Pig Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL-10 μg/mL	CSB-E06920p
C3	Monkey Complement 3(C3)ELISA Kit	serum, plasma, cell culture supernates	4.68 ng/mL-300 ng/mL	CSB-E16528Mk
C3	Mouse Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	93.75 ng/mL-6000 ng/mL	CSB-E08667m
C3	Fish Complement 3,C3 ELISA Kit	serum, plasma	12.5 μg/mL-500 μg/mL	CSB-E09727s
C3	Rabbit Complement 3,C3 ELISA Kit	serum, plasma	27.3 ng/mL-7000 ng/mL	CSB-E08668Rb
C3	Dog Complement 3(C3)ELISA Kit	serum, plasma, tissue homogenates	0.78 μg/mL-50 μg/mL	CSB-EL003888DO
CD38	Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit	serum, plasma, tissue homogenates, cell lysates	0.9 ng/mL-60 ng/mL	CSB-E09884h

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