Autoimmune Disease Series--

Psoriasis

Psoriasis is an immune-mediated skin disease that is stimulated by environmental factors and controlled by polygenic genes, and can be divided into four types: common, arthropathic, pustular and erythrodermic. Its typical manifestation is scaly erythematous plaques or plaques, which are confined to one place or widely distributed all over the body. In addition to skin damage, psoriasis may also affect the nails, joints and other parts of the body, and may even be accompanied by a variety of systemic comorbidities, such as metabolic syndrome, inflammatory bowel disease, cardiovascular disease, and mental disorders.

In recent years, significant progress has been made in drug development for psoriasis, especially in biological agents and small molecule targeted drugs. In terms of biological agents, a variety of targeted antibody drugs for psoriasis have been marketed or are in the research and development stage. These include TNF-α inhibitors, IL-12/23 inhibitors, IL-23 inhibitors, IL-17A inhibitors and IL-36 receptor inhibitors. These biologics can effectively control the symptoms of psoriasis by targeting specific inflammatory mediators. In terms of small molecule drugs, tyrosine kinase 2 (TYK2) variant inhibitors have been approved and marketed for patients with moderate to severe plaque psoriasis. In addition, JAK inhibitors, PDE4 inhibitors, and NRF2 stimulators are under development, which intervene in the pathogenesis of psoriasis through different signaling pathways.

CUSABIO provides psoriasis drug development target proteins, recombinant antibodies, ELISA kits and other products to help basic research and drug development.

Psoriasis Drug Targets Related Products

● Target Proteins

Recombinant Human Interleukin-17A (IL17A)
CSB-BP624104HU(M)

Recombinant Human Interleukin-2 (IL2)
CSB-MP011629HU

Recombinant Human Interleukin-6 (IL6)
CSB-YP011664HU

Recombinant Human Tumor necrosis factor (TNF)
CSB-YP023955HU

Target	Product Name	Source	Tag Info	Product Code
IFNG	Recombinant Human Interferon gamma protein (IFNG) (Active)	E.Coli	Tag-Free	CSB-AP002801HU
IFNG	Recombinant Rhesus Macaque Interferon gamma protein (IFNG) (Active)	E.Coli	Tag-Free	CSB-AP003241MOW
IFNG	Recombinant Human Interferon gamma (IFNG) (Active)	E.coli	Tag-Free	CSB-AP004201HU
IL10	Recombinant Human Interleukin-10 protein (IL10) (Active)	E.Coli	Tag-Free	CSB-AP001791HU
Il10	Recombinant Mouse Interleukin-10 (Il10) (Active)	E.coli	Tag-Free	CSB-AP004841MO
IL17A	Recombinant Human Interleukin-17A (IL17A) (Active)	E.coli	Tag-Free	CSB-AP004331HU
IL17A	Recombinant Human Interleukin-17A (IL17A) (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004341HU
Il17a	Recombinant Mouse Interleukin-17A (Il17a), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004781MO
IL17A	Recombinant Human Interleukin-17A (IL17A) (T26A) (Active)	Baculovirus	N-terminal 6xHis-tagged	CSB-BP624104HU(M)
IL1A	Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) (Active)	E.Coli	Tag-Free	CSB-AP003071MOW
Il1a	Recombinant Mouse Interleukin-1 alpha protein (Il1a) (Active)	E.Coli	Tag-Free	CSB-AP003251MO
IL1B	Recombinant Rhesus Macaque Interleukin-1 beta protein (IL1B) (Active)	E.Coli	Tag-Free	CSB-AP003081MOW
Il1b	Recombinant Mouse Interleukin-1 beta protein (Il1b) (Active)	E.Coli	Tag-Free	CSB-AP003261MO
IL1B	Recombinant Horse Interleukin-1 beta protein (IL1B) (Active)	E.Coli	Tag-Free	CSB-AP003481HO
IL2	Recombinant Human Interleukin-2 protein (IL2) (Active)	E.Coli	Tag-Free	CSB-AP001691HU
IL2	Recombinant Human Interleukin-2 (IL2) (Active)	E.coli	Tag-Free	CSB-AP004381HU
IL2	Recombinant Human Interleukin-2 (IL2) (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004501HU
IL2	Recombinant Human Interleukin-2 (IL2) (L100F,R101D,L105V,I106V,I112F) (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004711HU
Il2	Recombinant Mouse Interleukin-2 (Il2) (Active)	E.coli	Tag-Free	CSB-AP004821MO
IL2	Recombinant Human Interleukin-2 (IL2) (Active)	Mammalian cell	N-terminal hFc-tagged	CSB-MP011629HU

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● Antibodies

CD4 Recombinant Monoclonal Antibody
CSB-RA004935A0HU

Tested Applications: ELISA, WB, IHC

CD8A Recombinant Monoclonal Antibody
CSB-RA934881A0HU

Tested Applications: ELISA, IF, FC

IL12B Recombinant Monoclonal Antibody
CSB-RA895985A0HU

Tested Applications: ELISA, WB, IHC, IP

Phospho-STAT3 (S727) Recombinant Monoclonal Antibody
CSB-RA022812A727phHU

Tested Applications: ELISA, WB, IHC, IP

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD4	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA004935A0HU
CD8A	CD8A Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA934881A0HU
CRP	CRP Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA988767A0HU
IL10	IL10 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011580A0HU
IL12B	IL12B Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA895985A0HU
IL17A	IL17A Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA624104MA1HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
IL4	IL4 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA240377A0HU
IL6	IL6 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011664MA1HU
STAT3	Phospho-STAT3 (S727) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA022812A727phHU
STAT3	Phospho-STAT3 (Tyr705) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA022812A705phHU
STAT3	STAT3 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA546821A0HU
STAT3	STAT3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA229700A0HU
STAT3	STAT3 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA188270A0HU
STAT3	STAT3 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA022812MA1HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD4	CD4 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000228
CD4	CD4 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA043428
CD4	CD4 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA981329
CD4	CD4 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA124048
CD4	CD4 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA260243
CD4	CD4 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA570802
CD4	CD4 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA783233
CD4	CD4 Monoclonal Antibody,PE Conjugated	Mouse	ELISA, FC	CSB-MA084552
CD8A	CD8A Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA255790
CD8A	CD8A Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA955671
CD8A	CD8A Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA919476
CD8A	CD8A Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA574619
CD8A	CD8A Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA985168
CD8A	CD8A Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA927984
CD8A	CD8A Monoclonal Antibody,FITC Conjugated	Mouse	ELISA, IF, FC	CSB-MA248122
CD8A	CD8A Monoclonal Antibody,FITC Conjugated	Mouse	ELISA, FC	CSB-MA833547
CRP	CRP Monoclonal Antibody	Human	ELISA, IHC	CSB-MA027411E0m
CXCL8	CXCL8 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA083271A0m
IFNG	IFNG Monoclonal Antibody	Human	ELISA, IHC	CSB-MA065241A0m
IL1B	IL1B Monoclonal Antibody	Human	ELISA	CSB-MA065741A0m
IL1B	IL1B Monoclonal Antibody	Human	ELISA, WB, IHC, ICC	CSB-MA010884
IL6	IL6 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA067571A0m
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD4	CD4 Antibody	Human	ELISA, IHC	CSB-PA004935ESR2HU
CD4	Phospho-CD4 (S433) Antibody	Human, Mouse	ELISA, IHC, IF	CSB-PA070257
CD4	CD4 Antibody	Human, Mouse	ELISA, WB, IHC, IF	CSB-PA001453
CD4	CD4 Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA004935GA01HU
CD8A	CD8A Antibody	Human	ELISA, IHC	CSB-PA004966LA01HU
CRP	CRP Antibody	Human	ELISA, WB, IHC	CSB-PA06079A0Rb
crp	crp Antibody	Escherichia coli	ELISA	CSB-PA359785LA01ENV
CRP	CRP Antibody	Human, Rat	ELISA, WB	CSB-PA005116
CRP	CRP Antibody	Human	ELISA, WB, IHC	CSB-PA181901
CRP	CRP Antibody	Human	ELISA, WB, IHC	CSB-PA790121
CXCL8	CXCL8 Antibody	Dog	ELISA	CSB-PA011671YA01DO
CXCL8	CXCL8 Antibody	Human	ELISA, WB, IHC	CSB-PA08327A0Rb
CXCL8	CXCL8 Antibody	Gallus gallus	ELISA	CSB-PA15789A0Rb
CXCL8	CXCL8 Antibody	Human	ELISA, IF	CSB-PA08329A0Rb
CXCL8	CXCL8 Antibody	Human	ELISA, WB, IHC	CSB-PA003036
CXCL8	CXCL8 Antibody	Human	ELISA, WB	CSB-PA004977
CXCL8	CXCL8 Antibody	Human	ELISA, IHC	CSB-PA009564
CXCL8	CXCL8 Antibody	Human	ELISA, IHC	CSB-PA011671GA01HU
IER3	IER3 Antibody	Human	ELISA, IF	CSB-PA011002LA01HU
IFNG	IFNG Antibody	Human	ELISA, WB	CSB-PA011050HA01HU

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● ELISA Kits

Target	Product Name	Sample Types	Detection Range	Code
CD4	Human cluster of differentiation 4,CD4 ELISA Kit	serum, plasma	0.625 ng/mL-40 ng/mL	CSB-E08956h
CD4	Rat cluster of differentiation 4,CD4 ELISA Kit	serum, plasma, tissue homogenates	0.78 U/mL-50 U/mL	CSB-E12928r
CD4	Chicken Cluster of Differentiation 4(CD4) ELISA Kit	serum, plasma, tissue homogenates	3.125 ng/mL-800 ng/mL	CSB-E13114C
CD8A	Human Cluster of differentiation 8,CD8 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	62.5 U/mL-4000 U/mL	CSB-E12707h
CRP	Mouse C-Reactive Protein,CRP ELISA Kit	serum, plasma, tissue homogenates	5 ng/mL-4000 ng/mL	CSB-E07923m(1)
CRP	Rabbit C-Reactive Protein,CRP ELISA Kit	serum, plasma	7.8 pg/mL-2000 pg/mL	CSB-E06847Rb
CRP	Rat C-Reactive Protein,CRP ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	31.25 ng/mL-2000 ng/mL	CSB-E07922r
CRP	Mouse C-Reactive Protein,CRP ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	15.6 ng/mL-1000 ng/mL	CSB-E07923m
CRP	Pig C-reactive protein,CRP ELISA Kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-E08163p
CRP	Bovine C-reactive protein,CRP ELISA Kit	serum, plasma	1.25 ng/mL-80 ng/mL	CSB-E08577b
CRP	Canine C-Reactive Protein,CRP ELISA Kit	serum, plasma, cell culture supernates	0.312 μg/mL-20 μg/mL	CSB-E14262c
CRP	Sheep C-reactive protein(CRP) ELISA Kit	serum, plasma, tissue homogenates, cell lysates	0.625 μg/mL-40 μg/mL	CSB-E15081Sh
CRP	Hamster C-reactive protein(CRP) ELISA Kit	serum, plasma, tissue homogenates	12.5 ng/mL-800 ng/mL	CSB-EL005991HA
CXCL8	Human Interleukin 8,IL-8 ELISA KIT	serum, cell culture supernates, saliva, urine, cerebrospinal fluid (CSF), tissue homogenates, cell l	31.25 pg/mL-2000 pg/mL	CSB-E04641h
CXCL8	Pig interleukin 8,IL-8 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	125 pg/mL-8000 pg/mL	CSB-E06787p
CXCL8	Dog Interleukin-8,IL-8 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E08052c
CXCL8	Rabbit Interleukin 8,IL-8 ELISA Kit	serum, plasma, tissue homogenates	23.5 pg/mL-1500 pg/mL	CSB-E06905Rb
CXCL8	Monkey Interleukin-8,IL-8 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-E08051Mo
CXCL8	Bovine Interleukin 8,IL-8 ELISA Kit	serum, plasma, tissue homogenates	50 pg/mL-2000 pg/mL	CSB-E13052B
CXCL8	Guinea pig Interleukin 8,IL-8 ELISA Kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-E13096Gp

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