Autoimmune Disease Series--

Interstitial Lung Disease

Interstitial Lung Disease (ILD) comprises a heterogeneous group of disorders characterized by inflammation of the pulmonary parenchyma and progressive fibrosis. The core pathological mechanism involves repetitive alveolar epithelial injury followed by aberrant repair, leading to fibroblast activation, excessive deposition of extracellular matrix, and irreversible pulmonary scarring.

ILD encompasses over 200 subtypes, among which Idiopathic Pulmonary Fibrosis (IPF) is the most common and carries the poorest prognosis. It primarily affects individuals over 50 years of age, with a global prevalence of approximately 6.3 per 100,000 and a 5-year survival rate of only 20%-25%—lower than most cancers.

Clinical manifestations include progressive dyspnea, dry cough, and inspiratory crackles, with advanced stages potentially complicated by pulmonary hypertension and respiratory failure.

Recent drug development for ILD has focused on novel antifibrotic targets and disease-modifying therapies, with key advances including:

► PDE4B Inhibitors:

• Nerandomilast: Boehringer Ingelheim's oral selective PDE4B inhibitor, which elevates intracellular cAMP to suppress NF-κB/NFAT signaling and reduce pro-inflammatory cytokine release. Its Phase III FIBRONEER™-ILD trial met primary endpoints in February 2025, becoming the first successful Phase III novel drug in a decade. Applications for IPF and Progressive Pulmonary Fibrosis (PPF) indications have been submitted to regulatory authorities in China and the US.
• SYH2059: CSPC Pharmaceutical Group's highly selective PDE4B inhibitor with superior preclinical activity. Approved for clinical trials in China and the US in 2025, targeting ILD.

► Cell Therapy:

• NCR101 Injection: The world's first gene-edited induced pluripotent stem cell (iPSC)-derived mesenchymal-like cell (iMSC) therapy, engineered to enhance anti-inflammatory and tissue-repair functions. Received Chinese clinical approval in March 2025 for ILD treatment, overcoming limitations of traditional MSC heterogeneity and yield.

► Acute Exacerbation Management:

• Nintedanib: Systematic reviews demonstrate that initiating treatment during ILD acute exacerbation (AE-ILD) significantly reduces in-hospital mortality and shortens hospitalization potentially mediated through multi-kinase inhibition (PDGFR/VEGFR/FGFR) blocking fibrotic signaling.

► Emerging Targets:

• Anti-WISP1 Antibody (MTX-463): Developed by Lilly/Mediar, neutralizes WNT pathway protein WISP1 to inhibit fibroblast activation. Currently in Phase II trials.
• JAK Inhibitors (e.g., Ruxolitinib): Target JAK-STAT pathway to modulate macrophage polarization, showing 50% reduction in collagen deposition in preclinical models and exploring drug repurposing.

Interstitial Lung Disease Drug Targets Related Products

● Target Proteins

BSG
CSB-MP002831HU1

Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC₅₀ is 21.95-33.12 ng/ml.

CCN2
CSB-MP5112MOW

Measured by its binding ability in a functional ELISA. Immobilized Rhesus macaque CTGF at 1 μg/ml can bind Anti-CTGF recombinant antibody (CSB-RA006147MA2HU). The EC₅₀ is 0.6886-0.7825 ng/mL.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m,antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL.

CSF1
CSB-MP006043HU1

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.

IL13
CSB-MP6408HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 2.045-6.215 ng/mL

PDCD1
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL.

NT5E
CSB-MP723415HU

Measured by its binding ability in a functional ELISA. Immobilized CD73 at 2 μg/ml can bind Anti- CD73 Rabbit Monoclonal Antibody (CSB-RA978310A0HU), the EC₅₀ is 3.212-4.525 ng/ml.

TSLP
CSB-MP025141HUh7

Measured by its binding ability in a functional ELISA.Immobilized Human TSLP at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC₅₀ is 5.487-6.214 ng/mL.

Target	Product Name	Source	Tag Info	Product Code
B2M	Recombinant Sheep Beta-2-microglobulin (B2M)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP002486SH
B2M	Recombinant Pig Beta-2-microglobulin (B2M)	E.coli	Tag-free	CSB-EP4852PI
B2m	Recombinant Mesocricetus auratus Beta-2-microglobulin (B2m)	E.coli	Tag-Free	CSB-EP4853MRG
BSG	Recombinant Human Basigin (BSG), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP002831HU1
C5	Recombinant Human Complement C5 (C5), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003995HU
C5	Recombinant Rat Complement C5 (C5)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003995RA
C5	Recombinant Human Complement C5 (C5), partial	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP003995HU
C5	Recombinant Pig Complement C5a anaphylatoxin (C5)	Yeast	N-terminal 6xHis-tagged	CSB-YP003995PI
CCL2	Recombinant Human C-C motif chemokine 2 protein (CCL2)	E.coli	N-terminal GST-tagged	CSB-EP004783HU
CCL2	Recombinant Human C-C motif chemokine 2 (CCL2)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004783HUb1
CCL2	Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP004783MO
CCN2	Recombinant Human CCN family member 2 (CCN2)	E.coli	C-terminal 6xHis-tagged	CSB-EP006147HU
CCN2	Recombinant Human CCN family member 2 (CCN2), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP006147HU1
Ccn2	Recombinant Mouse CCN family member 2 (Ccn2), partial	E.coli	N-terminal 10xHis-SUMO-tagged	CSB-EP006147MO
Ccn2	Recombinant Mouse CCN family member 2 (Ccn2), partial	E.coli	N-terminal GST-tagged	CSB-EP006147MOe0
CCN2	Recombinant Macaca mulatta CCN family member 2 (CCN2)	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP5112MOW
Ccn4	Recombinant Rat CCN family member 4 (Ccn4), Biotinylated	E.coli	N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged	CSB-EP857523RA-B
CCR7	Recombinant Human C-C chemokine receptor type 7 (CCR7), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004846HU1
CD274	Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP878942HU2
CD274	Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP878942HU1

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● Antibodies

CD274 Recombinant Monoclonal Antibody
CSB-RA977797A0HU

Tested Applications:
ELISA, WB, IHC

ITGAV Recombinant Monoclonal Antibody
CSB-RA279866A0HU

Tested Applications:
ELISA, WB, IHC

LOXL2 Recombinant Monoclonal Antibody
CSB-RA907007A0HU

Tested Applications:
ELISA, WB, IHC, IF, FC

NT5E Recombinant Monoclonal Antibody
CSB-RA978310A0HU

Tested Applications:
ELISA, IHC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD274	CD274 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA977797A0HU
CD274	CD274 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA878942MA1HU
CXCR4	CXCR4 Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA569311A0HU
CXCR4	CXCR4 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA006254MA01HU
IL6	IL6 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011664MA1HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA548303A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA279866A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA011877MA1HU
LOXL2	LOXL2 Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB, IHC, IF, FC	CSB-RA907007A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
NT5E	NT5E Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA978310A0HU
TSLP	TSLP Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA025141A1HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CCL2	CCL2 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA058641A0m
ENG	ENG Monoclonal Antibody	Human	ELISA, IHC	CSB-MA294403
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IHC, IF, FC, IP	CSB-MA007670A0m
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IF, FC, IP	CSB-MA007670A1m
IL6	IL6 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA067571A0m
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
B2M	B2M Monoclonal Antibody	Human	ELISA, IHC	CSB-MA057861A0m
CCL2	CCL2 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA058641A0m
ENG	ENG Monoclonal Antibody	Human	ELISA, IHC	CSB-MA294403
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IHC, IF, FC, IP	CSB-MA007670A0m
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IF, FC, IP	CSB-MA007670A1m
IL6	IL6 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA067571A0m
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272
AREG	AREG Antibody	Human	ELISA, IHC, IF	CSB-PA11339A0Rb
AREG	AREG Antibody	Human	ELISA, WB	CSB-PA006314
AREG	AREG Antibody	Human	ELISA, WB, IHC, IF	CSB-PA001986GA01HU
AREG	AREG Antibody	Human	ELISA, WB	CSB-PA441346
AREG	AREG Antibody	Human	ELISA, WB	CSB-PA694774
B2M	B2M Antibody	Human, Mouse	ELISA, WB, IHC	CSB-PA002486YA01HU
B2M	B2M Antibody	Human, Mouse	ELISA, WB	CSB-PA05786A0Rb
B2m	B2m Antibody	Mouse	ELISA, WB, IHC	CSB-PA002486LA01MO
B2M	B2M Antibody	Human, Mouse, Rat	ELISA, FC, IF, IHC, WB	CSB-PA002486GA01HU

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● ELISA Kits

Mouse Tumor necrosis factor α,TNF-α ELISA KIT
CSB-E04741m

Mouse Interleukin 6,IL-6 ELISA KIT
CSB-E04639m

Mouse Transforming Growth factor β1,TGF-β1 ELISA kit
CSB-E04726m

Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit
CSB-E07430m

Target	Product Name	Sample Types	Detection Range	Code
CSF2	Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04568h
IL6	Human Interleukin 6,IL-6 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, urine	7.8 pg/mL-500 pg/mL	CSB-E04638h
CCL2	Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis	6.25 pg/ml-400 pg/ml.	CSB-E04655h
CSF1	Mouse Macrophage Colony-Stimulating Factor,M-CSF ELISA kit	serum, plasma, tissue homogenates	7.81 pg/mL-500 pg/mL	CSB-E04659m
TGFB1	Human Transforming Growth factor β1,TGF-β1 ELISA kit	serum, plasma, cell culture supernates	0.78 ng/mL-50 ng/mL	CSB-E04725h
TGFB1	Dog Transforming growth factor β1,TGF-β1 ELISA Kit	serum, plasma	0.781 ng/ml - 50 ng/ml	CSB-E04796c
B2M	Human β2-microglobulin,BMG/β2-MG ELISA Kit	serum, urine	0.039 μg/mL-10 μg/mL	CSB-E04883h
CCL2	Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, tissue homogenates	78 pg/mL-5000 pg/mL	CSB-E07430m
ENG	Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit	serum, plasma, tissue homogenates	6.25 ng/mL-400 ng/mL	CSB-E09921m
CSF1R	Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E10012h
ENG	Human Soluble Endoglin,sENG/sCD105 ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E10030h
CCL2	Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit	serum, plasma, tissue homogenates	0.125 ng/mL-8 ng/mL	CSB-E15747c
IL6R	Human Interleukin 6 receptor(IL-6R)ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E16524h
TNF	Pig Tumor necrosis factor (TNF/TNFA/TNFSF2) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.047 ng/mL-3 ng/mL	CSB-E16980p
IL6	Mouse Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates	3.9 pg/ml-250 pg/ml	CSB-E04639m-IS
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA KIT	q	62.5 pg/mL-4000 pg/mL	CSB-E04741m(1)
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates	7.8 pg/ml-500 pg/ml	CSB-E04741m-IS
AREG	Human keratinocyte autocrine factor/Amphiregulin,KAF/AR ELISA Kit	serum, plasma	4.7 pg/mL-300 pg/mL	CSB-E04496h
CSF2	Mouse Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04569m
CSF2	Rat Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/ml - 1000 pg/ml	CSB-E04570r

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Click to view CUSABIO Cytokine ELISA kits

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