Autoimmune Disease Series--

Myasthenia Gravis

Myasthenia gravis (MG) is a rare chronic autoimmune neuromuscular disorder caused by pathogenic immunoglobulin G antibodies attacking postsynaptic components at the neuromuscular junction (such as AChR and MuSK), leading to impaired neural signal transmission. Clinical manifestations include fluctuating muscle weakness and fatigue, commonly affecting eye muscles, bulbar muscles, and limb muscles. In severe cases, it can lead to respiratory failure. Approximately 85% of patients have generalized myasthenia gravis (gMG), with AChR antibody positivity being predominant, and those with MuSK antibody positivity exhibiting more severe symptoms. The pathogenesis of this disease involves antibody-mediated complement activation and the recycling and maintenance of pathogenic IgG by FcRn receptors, leading to sustained autoimmune damage.

Recent drug development progress in MG has focused on two core mechanisms: targeting the clearance of pathogenic antibodies and regulating the complement pathway, resulting in a treatment landscape dominated by FcRn inhibitors and complement C5 inhibitors:

● FcRn-targeted drugs accelerate the degradation of pathogenic antibodies by blocking FcRn-IgG binding, making them the most active area of current research and development. Representative drugs include efgartigimod, rozanolixizumab , and nipocalimab.

● Complement C5 inhibitors reduce the formation of membrane attack complexes by blocking the terminal complement cascade. Representative drugs include ravulizumab.

Future drugs for myasthenia gravis (MG) will evolve from broad-spectrum immunosuppression to precise targeting. FcRn and C5 inhibitors currently account for 67% of innovative drugs, while dual-target drugs and CAR-T therapies without chemotherapy are expected to further break through treatment bottlenecks for refractory patients.

Myasthenia Gravis Drug Targets Related Products

● Target Proteins

CD40
CSB-MP004936HU1

Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC₅₀ is 3.112-3.858 ng/ml.

CLEC4C
CSB-MP855470HUh7

Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody(CSB-RA855470MA1HU)，the EC₅₀ is 7.658-12.99 ng/mL.

MS4A1
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL.

TNFSF13B
CSB-MP897523HU1-B

Measured by its binding ability in a functional ELISA. Immobilized human BCMA (CSB-MP023974HU1) at 5 μg/ml can bind Biotinylated human TNFSF13B, the EC₅₀ is 0.1752-0.3657 ng/ml.

Target	Product Name	Source	Tag Info	Product Code
ACHE	Recombinant Bovine Acetylcholinesterase (ACHE)	E.coli	N-terminal GST-tagged	CSB-EP001154BO
Ache	Recombinant Rat Acetylcholinesterase (Ache)	E.coli	N-terminal 6xHis-tagged	CSB-EP001154RA
ACHE	Recombinant Human Motor neuron and pancreas homeobox protein 1 (ACHE)	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP001154HU
ACHE	Recombinant Human Motor neuron and pancreas homeobox protein 1（ACHE)	Mammalian cell	C-terminal hFc-tagged	CSB-MP001154HUd9
Afp	Recombinant Mouse Alpha-fetoprotein (Afp)	E.coli	N-terminal 6xHis-tagged	CSB-EP001421MO
Afp	Recombinant Mouse Alpha-fetoprotein (Afp)	E.coli	Tag-Free	CSB-EP001421MOe1
afp	Recombinant Aspergillus giganteus Antifungal protein (afp)	E.coli	N-terminal 6xHis-B2M-tagged	CSB-EP325933APN
Afp	Recombinant Mouse Alpha-fetoprotein (Afp)	Yeast	N-terminal 6xHis-tagged	CSB-YP001421MO
Afp	Recombinant Rat Alpha-fetoprotein (Afp)	E.coli	C-terminal 6xHis-tagged	CSB-EP001421RA
BTK	Recombinant Human Tyrosine-protein kinase BTK (BTK)	Baculovirus	N-terminal 10xHis-tagged	CSB-BP002867HU(A4)
BTK	Recombinant Human Tyrosine-protein kinase BTK (BTK)	Yeast	N-terminal 6xHis-tagged	CSB-YP002867HU
BTK	Recombinant Human Tyrosine-protein kinase BTK (BTK), partial	E.coli	Tag-Free	CSB-EP002867HU1
C1S	Recombinant Human Complement C1s subcomponent (C1S)	E.coli	N-terminal 10xHis-tagged	CSB-EP003657HU
C3	Recombinant Mouse Complement C3 (C3), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP365507MO
C3	Recombinant Bovine Complement C3 (C3), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP647263BO
C3	Recombinant Human Complement C3 (C3), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP355590HU
C3	Recombinant Rat Complement C3 (C3), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP360475RA
C5	Recombinant Human Complement C5 (C5), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003995HU
C5	Recombinant Rat Complement C5 (C5)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003995RA
C5	Recombinant Human Complement C5 (C5), partial	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP003995HU

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● Antibodies

C3 Recombinant Monoclonal Antibody
CSB-RA303909A0HU

Tested Applications:
ELISA, WB, IHC, FC

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

CD38 Recombinant Monoclonal Antibody
CSB-RA796695A0HU

Tested Applications:
ELISA, WB, IHC

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Tested Applications:
ELISA, IHC, IF, FC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
BTK	BTK Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA553167A0HU
C3	C3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-RA303909A0HU
C3	C3 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA699863A0HU
C5	C5 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA003995MA1HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
CD38	CD38 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA796695A0HU
CD4	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA004935A0HU
CD40	CD40 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA004936MA1HU
CLEC4C	CLEC4C Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA855470MA1HU
EGFR	Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA007479A1092phHU
EGFR	Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA007479A1068phHU
EGFR	EGFR Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-RA159341A0HU
EGFR	EGFR Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA794061A0HU
EGFR	EGFR Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA159341MA1HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
AFP	AFP Monoclonal Antibody	Human	ELISA, IHC	CSB-MA027711A0m
AFP	AFP Monoclonal Antibody	Human	ELISA, IHC	CSB-MA027711E0m
AFP	AFP Monoclonal Antibody	Human	ELISA, WB	CSB-MA000233
AFP	AFP Monoclonal Antibody	Human	ELISA, WB	CSB-MA099203
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
CD38	CD38 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA785760
CD4	CD4 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000228
CD4	CD4 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA043428
CD4	CD4 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA981329
CD4	CD4 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA124048
CD4	CD4 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA260243
CD4	CD4 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA570802
CD4	CD4 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA783233

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- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
ACHE	ACHE Antibody	Human	ELISA, IHC, IF	CSB-PA5619A0Rb
ache	ache Antibody	Zebrafish	ELISA, WB	CSB-PA863598LA01DIL
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA010202
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA010203
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA001154GA01HU
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA904467
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA114463
ACHE	ACHE Antibody	Human	ELISA, WB	CSB-PA547258
AFP	AFP Antibody	Human	ELISA, IHC	CSB-PA09987A0Rb
AFP	AFP Antibody	Human	ELISA, WB	CSB-PA09989A0Rb
afp	afp Antibody	Aspergillus giganteus	ELISA	CSB-PA325933LA01APN
AFP	AFP Antibody	Human	ELISA, WB	CSB-PA004875
AFP	AFP Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA001421GA01HU
AFP	AFP Antibody	Human	ELISA, WB, IHC	CSB-PA251527
AFP	AFP Antibody	Human	ELISA, WB, IHC	CSB-PA787484
AFP	AFP Antibody	Human	ELISA, IHC	CSB-PA145342
AFP	AFP Antibody	Human	ELISA, WB, IHC	CSB-PA230953
AFP	AFP Antibody	Human	ELISA, WB	CSB-PA075526
BTK	BTK Antibody	Human, Mouse	ELISA, WB, IHC, IF	CSB-PA002867LA01HU
BTK	Phospho-BTK (Y223) Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA000638

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● ELISA Kits

Human Vascular Endothelial cell Growth Factor(VEGF) ELISA KIT
CSB-E11718h

Rat Acetylcholinesterase, AChE ELISA Kit
CSB-E11304r

Fish Acetylcholinesterase (AChE) ELISA Kit
CSB-E17001Fh

Rat Complement fragment 5,C5 ELISA Kit
CSB-E14363r

Target	Product Name	Sample Types	Detection Range	Code
ACHE	Rat Acetylcholinesterase,AChE ELISA Kit	serum, plasma, tissue homogenates	7.8 pg/mL-500 pg/mL	CSB-E11304r
AChE	Fish Acetylcholinesterase(AChE)ELISA Kit	serum, plasma, tissue homogenates	2.5 ng/mL-40 ng/mL	CSB-E17001Fh
ACHE	Human Acetylcholinesterase,AChE ELISA Kit	serum, plasma, tissue homogenates	0.94 mU/mL-60 mU/mL	CSB-E09670h
AChE	Mouse Acetylcholinesterase(AChE)ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	0.312 mU/mL-20 mU/mL	CSB-E17521m
AFP	Human Alpha-fetoprotein,AFP ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	1.563 ng/mL-100 ng/mL	CSB-E04770h
AFP	Rat Alpha-fetoprotein,AFP ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E08281r
AFP	Mouse Alpha-fetoprotein,AFP ELISA Kit	serum, plasma, tissue homogenates.	1.23 ng/ml-900 ng/ml.	CSB-E08282m
AFP	Pig Alpha-fetoprotein(AFP) ELISA kit	serum, plasma, tissue homogenates, cell culture supernates	3.12 ng/mL-200 ng/mL	CSB-EL001421PI
C1S	Human Complement C1s subcomponent(C1S) ELISA kit	serum, plasma, tissue homogenates	25 ng/mL-1600 ng/mL	CSB-EL003657HU
C3	Fish Complement 3,C3 ELISA Kit	serum, plasma	12.5 μg/mL-500 μg/mL	CSB-E09727s
C3	Human Complement 3,C3 ELISA Kit	serum, plasma, cell culture supernates, urine, saliva	4.7 ng/mL-300 ng/mL	CSB-E08665h
C3	Rat Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL-40 μg/mL	CSB-E08666r
C3	Pig Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL-10 μg/mL	CSB-E06920p
C3	Mouse Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	93.75 ng/mL-6000 ng/mL	CSB-E08667m
C3	Rabbit Complement 3,C3 ELISA Kit	serum, plasma	27.3 ng/mL-7000 ng/mL	CSB-E08668Rb
C3	Dog Complement 3(C3)ELISA Kit	serum, plasma, tissue homogenates	0.78 μg/mL-50 μg/mL	CSB-EL003888DO
C3	Monkey Complement 3(C3)ELISA Kit	serum, plasma, cell culture supernates	4.68 ng/mL-300 ng/mL	CSB-E16528Mk
C5	Rat Complement fragment 5,C5 ELISA Kit	serum, plasma, tissue homogenates	9.38 ng/mL-600 ng/mL	CSB-E14363r
C5	Mouse Complement 5,C5 ELISA Kit	serum, plasma, tissue homogenates	0.25 ng/mL-16 ng/mL	CSB-E13802m
C5	Monkey complement C5 (C5) ELISA kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-EL003995MK

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