Autoimmune Disease Series--

Crohn's Disease

Crohn's Disease (CD) is a chronic inflammatory bowel disease, a type of inflammatory bowel disease. It can affect any part of the digestive tract, from the mouth to the anus, but is most common in the end of the small intestine (ileum) and the large intestine (colon). It usually presents as a segmental inflammation of the gastrointestinal tract and may cause symptoms such as abdominal pain, diarrhea, rectal bleeding, weight loss, fever and fatigue.

The current treatment strategy for Crohn's disease focuses on the use of medications to control inflammation and prompt surgical intervention to alleviate the symptoms of intestinal injury, with drug development focusing on the following directions:

• Anti-TNF drugs: Infliximab and Adalimumab are widely used anti-TNF drugs, and they show good efficacy and safety in the treatment of Crohn's disease.
• JAK Inhibitors: Upadacitinib and Tofacitinib are new treatment options, especially Upadacitinib has been approved for the treatment of moderate to severe Crohn's disease and has shown significant efficacy and safety.
• IL-23 inhibitors: Guselkumab and Risankizumab target the p19 subunit of IL-23 and are effective in inducing and sustaining remission, and have been shown to have positive results in clinical trials.
• CCR9 antagonist: CCX282-B is a novel drug that inhibits the intestinal inflammatory response by targeting the CCR9 receptor and is currently in preclinical studies.
• α4β7 integrin inhibitor: Vedolizumab has been approved by the FDA for the treatment of Crohn's disease, showing favorable efficacy and safety.

Other novel drugs in development include those targeting the IL-12/23 axis and those based on gene therapy, which are expected to provide more treatment options for Crohn's disease patients.

CUSABIO has long been committed to providing researchers with high-quality proteins, antibodies, ELISA kits and other tools for scientific research reagents, and has compiled a series of popular targets related to Crohn's disease research and related reagent products listed below for your selection:

Crohn's Disease Drug Targets Related Product Recommendations

● Target Proteins

CCR9
CSB-MP004848HU

Measured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10μg/mL can bind Anti-CCR9 recombinant antibody (CSB-RA004848MA1HU)，the EC₅₀ is 31.67-36.83 ng/mL.The VLPs (CSB-MP3838) is negative control

CD40
CSB-MP004936HU1

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC₅₀ is 2.353-3.232 ng/ml.

CD40LG
CSB-MP004937HU3

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC₅₀ is 2.353-3.232 ng/ml.

IL17A
CSB-BP624104HU(M)

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC₅₀ is 1.818-2.170 ng/mL.

IL6
CSB-YP011664HU

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU)，the EC₅₀ is 35.80-41.82 ng/mL.

KLRK1
CSB-MP012474HU1

Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.

OSM
CSB-MP017260HU1

Measured by its binding ability in a functional ELISA. Immobilized Human OSM at 2μg/mL can bind Anti-OSM recombinant antibody (CSB-RA017260MA1HU)，the EC₅₀ is 3.048-3.860 ng/mL.

TNFSF15
CSB-MP023992HU(F2)

Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml can bind Anti-TNFSF15 recombinant antibody(CSB-RA023992MA1HU). The EC₅₀ is 0.8389-0.9731 ng/mL.

Target	Product Name	Source	Tag Info	Product Code
CCR9	Recombinant Human C-C chemokine receptor type 9 (CCR9), partial	E.coli	N-terminal GST-tagged	CSB-EP004848HU1
CCR9	Recombinant Human C-C chemokine receptor type 9 (CCR9)-VLPs (Active)	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)	CSB-MP004848HU
CD226	Recombinant Human CD226 antigen (CD226), partial (Active)	Mammalian cell	C-terminal hFc-Myc-tagged	CSB-MP618996HU
CD38	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial	Mammalian cell	C-terminal hFc-tagged	CSB-MP004929HU1
CD38	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial	Yeast	C-terminal 6xHis-tagged	CSB-YP004929HU1
CD38	Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial	E.coli	N-terminal GST-tagged	CSB-EP004929HU2
CD4	Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004935HU1
Cd4	Recombinant Mesocricetus auratus T-cell surface glycoprotein CD4 (Cd4), partial	E.coli	N-terminal GST-tagged and C-terminal Strep II-tagged	CSB-EP4837MRG
CD40	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005181HU
CD40	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP004936HU1
CD40	Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial	E.coli	C-terminal 6xHis-tagged	CSB-EP851448PI
CD40	Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial	Yeast	C-terminal hFc-tagged	CSB-YP851448PI
CD40	Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial	Yeast	C-terminal 6xHis-tagged	CSB-YP851448PIc7
CD40	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial	Baculovirus	C-terminal hFc-Avi-tagged	CSB-BP004936HU1
CD40LG	Recombinant Macaca mulatta CD40 ligand (CD40LG), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP004937MOW
CD40LG	Recombinant Rabbit CD40 ligand (CD40LG), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP004937RB
CD40LG	Recombinant Human CD40 ligand (CD40LG), partial	E.coli	N-terminal GST-tagged	CSB-RP060054h
CD40LG	Recombinant Human CD40 ligand (CD40LG), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004937HU1
CD40LG	Recombinant Rabbit CD40 ligand (CD40LG), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004937RB
CD40LG	Recombinant Human CD40 ligand (CD40LG), partial (Active)	E.coli	Tag-Free	CSB-AP005191HU

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● Antibodies

CD38 Recombinant Monoclonal Antibody
CSB-RA796695A0HU

Tested Applications:
ELISA, WB, IHC

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Tested Applications:
ELISA, IF, FC

MADCAM1 Recombinant Monoclonal Antibody
CSB-RA215817A0HU

Tested Applications:
ELISA, FC

MMP9 Recombinant Monoclonal Antibody
CSB-RA014679A0HU

Tested Applications:
ELISA, IHC, FC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CCR9	CCR9 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB, IF, IP	CSB-RA004848A0HU
CCR9	CCR9 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004848MA1HU
CD38	CD38 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA796695A0HU
CD4	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA004935A0HU
CD40	CD40 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA004936MA1HU
CXCL10	CXCL10 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA903061A0HU
IL17A	IL17A Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA624104MA1HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
IL6	IL6 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011664MA1HU
ITGA4	ITGA4 Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA225859A0HU
MADCAM1	MADCAM1 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA215817A0HU
MMP9	MMP9 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA014679A0HU
OSM	OSM Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA017260MA1HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD38	CD38 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA785760
CD4	CD4 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000228
CD4	CD4 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA043428
CD4	CD4 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA981329
CD4	CD4 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA124048
CD4	CD4 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA260243
CD4	CD4 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA570802
CD4	CD4 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA783233
CD4	CD4 Monoclonal Antibody,PE Conjugated	Mouse	ELISA, FC	CSB-MA084552
IL6	IL6 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA067571A0m
SELL	SELL Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA289436
SELL	SELL Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA266548
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CCR9	CCR9 Antibody	Human, Mouse	ELISA, IHC	CSB-PA035070
CCR9	CCR9 Antibody	Human, Mouse	ELISA, IHC	CSB-PA293047
CD226	CD226 Antibody	Human	ELISA, WB, IHC	CSB-PA618996ESR2HU
CD226	CD226 Antibody	Human	ELISA, WB	CSB-PA005645
CD226	Phospho-CD226 (S329) Antibody	Human, Mouse, Monkey	ELISA, WB, IHC, IF	CSB-PA006678
CD226	CD226 Antibody	Human, Mouse, Monkey	ELISA, WB, IHC, IF	CSB-PA006679
CD226	CD226 Antibody	Human	ELISA, WB	CSB-PA004901GA01HU
CD226	CD226 Antibody	Human	ELISA, IHC	CSB-PA968069
CD226	CD226 Antibody	Human	ELISA, IHC	CSB-PA016936
CD38	CD38 Antibody	Human	ELISA, IHC	CSB-PA004929ESR1HU
CD38	CD38 Antibody	Human	ELISA, WB	CSB-PA005628
CD38	CD38 Antibody	Human	ELISA, WB	CSB-PA134528
CD38	CD38 Antibody	Human	ELISA, WB, IHC	CSB-PA926996
CD3D	CD3D Antibody	Human	ELISA, IHC	CSB-PA004930ESR1HU
CD3D	CD3D Antibody	Human	ELISA, WB	CSB-PA001452
CD3D	CD3D Antibody	Human	ELISA, WB	CSB-PA005826
CD3D	CD3D Antibody	Human, Mouse, Rat	ELISA, WB, IF	CSB-PA004930GA01HU
CD4	CD4 Antibody	Human	ELISA, IHC	CSB-PA004935ESR2HU
CD4	Phospho-CD4 (S433) Antibody	Human, Mouse	ELISA, IHC, IF	CSB-PA070257
CD4	CD4 Antibody	Human, Mouse	ELISA, WB, IHC, IF	CSB-PA001453

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● ELISA Kits

Mouse IL-18 ELISA Kit
CSB-E04609m

46 Citations

Mouse IL-6 ELISA KIT
CSB-E04639m

292 Citations

Human MMP-9 ELISA Kit
CSB-E08006h

31 Citations

Mouse TNF-α ELISA KIT
CSB-E04741m

381 Citations

Target	Product Name	Sample Types	Detection Range	Code
CD226	Human CD226 antigen(CD226) ELISA kit	serum, plasma, tissue homogenates	0.9 ng/mL-60 ng/mL	CSB-EL004901HU
CD38	Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit	serum, plasma, tissue homogenates, cell lysates	0.9 ng/mL-60 ng/mL	CSB-E09884h
CD38	Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-EL004929MO
CD4	Human cluster of differentiation 4,CD4 ELISA Kit	serum, plasma	0.625 ng/mL-40 ng/mL	CSB-E08956h
CD4	Rat cluster of differentiation 4,CD4 ELISA Kit	serum, plasma, tissue homogenates	0.78 U/mL-50 U/mL	CSB-E12928r
CD4	Chicken Cluster of Differentiation 4(CD4) ELISA Kit	serum, plasma, tissue homogenates	3.125 ng/mL-800 ng/mL	CSB-E13114C
CD40	Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit		Request Information	CSB-EL004936MO
CD40LG	Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E04716h
CD40LG	Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates.	0.274 ng/ml-200 ng/ml.	CSB-E04717m
CD40LG	Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	serum, plasma, tissue homogenates	1.87 ng/mL-120 ng/mL	CSB-E07395r
CX3CL1	Human Fractalkine,FK ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E04558h
CX3CL1	Mouse Fractalkine,FK ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	125 pg/mL-8000 pg/mL	CSB-E04559m
CX3CL1	Rat Fractalkine,FK ELISA Kit	serum, plasma	0.312 ng/mL-20 ng/mL	CSB-E04560r
CXCL10	Human interferon-inducible protein 10,IP-10 ELISA Kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-E08181h
CXCL10	Rat interferon-inducible protein 10,IP-10 ELISA Kit	serum, plasma, tissue homogenates	781.25 pg/mL-50000 pg/mL	CSB-E08182r
CXCL10	Mouse interferon-inducible protein 10,IP-10 ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/ml - 20 ng/ml	CSB-E08183m
CXCL10	Monkey C-X-C motif chemokine 10(CXCL10) ELISA kit	serum, plasma, tissue homogenates	62.5 pg/mL-4000 pg/mL	CSB-EL006240RH
IL12A	Bovine Interleukin 12,IL-12 ELISA Kit	serum, plasma, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E14010B
IL13	Human Interleukin 13,IL-13 ELISA KIT	serum, plasma, tissue homogenates	0.39 ng/ml-25 ng/ml.	CSB-E04601h
IL13	Mouse Interleukin 13,IL-13 ELISA Kit	serum, plasma, tissue homogenates	78 pg/ml - 5000 pg/ml	CSB-E04602m

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