Autoimmune Disease Series--

Ulcerative Colitis

Ulcerative colitis (UC) is a chronic, nonspecific inflammatory intestinal disease primarily affecting the colon and rectum. It is a subtype of inflammatory bowel disease (IBD). Its etiology is closely associated with genetic susceptibility, abnormal immune system activation, intestinal dysbiosis, and environmental factors (e.g., smoking, diet). Patients present with persistent or recurrent symptoms such as diarrhea, mucopurulent bloody stools, abdominal pain, and tenesmus.

Current UC drug development is shifting from broad-spectrum anti-inflammatory agents to targeted therapies. Biologics (e.g., IL-23, TL1A inhibitors) and precision small molecules (e.g., S1PR1-biased agonists) are emerging as frontier directions. Additionally, traditional Chinese medicine (TCM)-based multi-target regulation and novel technologies (nanomedicine, epigenetic interventions) offer new strategies to overcome therapeutic bottlenecks:

► Biologics

• IL-23/IL-12 Pathway: Xinda Biotech’s Picankibart (IL-23p19 mAb) demonstrates excellent efficacy and safety in Phase II trials, marking China’s first IL-23-targeted UC therapy. Merck’s MK-7240 (TL1A inhibitor) significantly improved endoscopic scores in Phase II trials, achieving a 26.5% clinical remission rate at 12 weeks, and has entered Phase III.
• Integrin Targets: Vedolizumab, which blocks lymphocyte migration to the gut mucosa, outperforms adalimumab in head-to-head comparisons. Etrolizumab (same target) failed due to inconsistent efficacy.
• Chemokines/Inflammatory Cytokines: Mendelian randomization studies suggest CXCL5 reduces IBD risk, while CXCL9 increases it, highlighting their therapeutic potential ^[1]. Genetically predicted lower CD40 levels correlate with reduced IBD risk, likely via immune cell interaction modulation.

► Small Molecule Drugs

• S1P Receptors: SAR247799 selectively activates S1PR1-G protein signaling, preserving endothelial barrier integrity with fewer off-target effects than non-selective modulators. Pfizer’s Etrasimod and approved Ozanimod show robust efficacy in refractory UC.
• JAK-STAT Pathway: JAK inhibitors (e.g., tofacitinib) alleviate UC symptoms by blocking inflammatory signaling but face limitations due to cardiovascular and infection risks.
• Purinergic Signaling: Researchers at China Pharmaceutical University identified P2Y14R inhibition as a novel target, reducing intestinal epithelial necroptosis via the cAMP/PKA/CREB axis.

► TCM Multi-Target Regulation

• Scutellaria baicalensis-Coptis chinensis Herb Pair: Modulates cytokine signaling, oxidative stress, and apoptosis pathways via AKT1, IL-6, TNF, etc., with core targets including CASP3 and PTGS2 ^[2].
• Artemisinin: Targets GALNT2, BMP7, and TGFBR2 to regulate immunity and inflammation, with structure optimization via computer-aided design ^[3].

► Novel Targets and Technologies

• Epigenetic Regulation: A Zhejiang University team discovered that enhancer RNA at the Sirpa locus regulates macrophage SIRPα expression, emerging as a UC target. Antisense oligonucleotides validated efficacy in murine models.
• Protein Interaction Targets: PDIA1 overexpression in UC intestinal epithelia impairs barrier function; its inhibition is under drug screening. Macrophage-specific NOC4L knockout alleviates UC symptoms, showing diagnostic and therapeutic potential.
• Nanomedicine: Nanoparticle-based drug delivery systems modulate macrophage polarization, reducing pro-inflammatory cytokines (IL-1β, TNF-α).

CUSABIO specializes in providing high-quality research tools, including proteins, antibodies, and ELISA kits. Below is a curated list of popular UC-related targets and reagents for your research needs:

Ulcerative Colitis Drug Targets Related Products

● Target Proteins

CD40
CSB-MP004936HU1

Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC₅₀ is 3.112-3.858 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

IL2RA
CSB-MP011649HU3

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

IL4R
CSB-MP011661HU2-B

Measured by its binding ability in a functional ELISA. Immobilized Human IL4(CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC₅₀ is 12.68-14.23 ng/mL

MS4A1
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

TNFSF15
CSB-MP023992HU(F2)

Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml can bind Anti-TNFSF15 recombinant antibody(CSB-RA023992MA1HU). The EC₅₀ is 0.8389-0.9731 ng/mL

TNFSF8
CSB-MP023996HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30(CSB-MP023983HU1h6) at 5 μg/ml can bind human CD30L, the EC₅₀ is 9.531-12.49 ng/ml.

Target	Product Name	Source	Tag Info	Product Code
CCL11	Recombinant Human Eotaxin (CCL11)	E.coli	N-terminal GST-tagged	CSB-EP004775HU
CCL20	Recombinant Human C-C motif chemokine 20 (CCL20), partial	E.coli	N-terminal GST-tagged	CSB-EP004784HU1
CCL20	Recombinant Macaca mulatta Chemokine CCL20/MIP-3ALPHA (CCL20)	E.coli	N-terminal 10xHis-GST-tagged	CSB-EP004784MOW
CCL20	Recombinant Macaca mulatta Chemokine CCL20/MIP-3ALPHA (CCL20)	E.coli	N-terminal GST-tagged	CSB-EP004784MOWe0
CCL20	Recombinant Bovine C-C motif chemokine 20 (CCL20)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP840478BO
CCL20	Recombinant Bovine C-C motif chemokine 20 (CCL20)	Yeast	N-terminal 6xHis-tagged	CSB-YP840478BO
CCL20	Recombinant Human C-C motif chemokine 20 (CCL20), partial	E.coli	N-terminal 6xHis-GST-tagged	CSB-EP004784HU1c0
CCR5	Recombinant Human C-C chemokine receptor type 5 (CCR5)	in vitro E.coli expression system	N-terminal 10xHis-tagged	CSB-CF004844HU
Ccr5	Recombinant Mouse C-C chemokine receptor type 5 (Ccr5), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004844MO
CD40	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005181HU
CD40	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP004936HU1
CD40	Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial	E.coli	C-terminal 6xHis-tagged	CSB-EP851448PI
CD40	Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial	Yeast	C-terminal hFc-tagged	CSB-YP851448PI
CD40	Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial	Yeast	C-terminal 6xHis-tagged	CSB-YP851448PIc7
CD40	Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial	Baculovirus	C-terminal hFc-Avi-tagged	CSB-BP004936HU1
CTLA4	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP006163HU1
Ctla4	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial	E.coli	N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged	CSB-EP006163MO1
CTLA4	Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	Yeast	C-terminal 6xHis-tagged	CSB-AP005121GU
Ctla4	Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP005301MO
CTLA4	Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP006163HU1

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● Antibodies

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Tested Applications:
ELISA, IF, FC

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Tested Applications:
ELISA, WB, IF, FC

MMP9 Recombinant Monoclonal Antibody
CSB-RA014679MA1HU

Tested Applications:
ELISA, IHC

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD40	CD40 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA004936MA1HU
CTLA4	CTLA4 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA213310A0HU
CTLA4	CTLA4 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB, IF, FC	CSB-RA006163MA1HU
CXCL10	CXCL10 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA903061A0HU
IL12B	IL12B Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA895985A0HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
IL2RA	IL2RA Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA011649MA1HU
MADCAM1	MADCAM1 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA215817A0HU
MMP9	MMP9 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA014679A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU
SELPLG	SELPLG Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA567010A0HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CTLA4	CTLA4 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA006163A0m
IL2RA	IL2RA Monoclonal Antibody	Human	ELISA, IHC	CSB-MA000266
LAG3	LAG3 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA012719A0m
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CCL11	CCL11 Antibody	Human	ELISA, WB, IHC	CSB-PA004775ESR2HU
CCL11	CCL11 Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA005780
CCL11	CCL11 Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA004775GA01HU
CCL20	CCL20 Antibody	Human, Mouse	ELISA, IHC	CSB-PA389153
Ccr5	Ccr5 Antibody	Mouse	ELISA	CSB-PA004844LA01MO
CCR5	CCR5 Antibody	Human, Mouse	ELISA, WB, IF	CSB-PA004844LA01HU
CCR5	Phospho-CCR5 (S349) Antibody	Human	ELISA, WB	CSB-PA000640
CCR5	CCR5 Antibody	Human	ELISA, WB	CSB-PA006994
CCR5	Phospho-CCR5 (S336) Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA006995
CCR5	CCR5 Antibody	Human, Mouse, Rat	ELISA, IHC	CSB-PA006993
CCR5	CCR5 Antibody	Human	ELISA, WB, IHC	CSB-PA792075
CCR5	CCR5 Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA004844GA01HU
CCR5	CCR5 Antibody	Human, Mouse	ELISA, IHC	CSB-PA548882
CCR5	CCR5 Antibody	Human, Mouse	ELISA, IHC	CSB-PA265884
CCR5	CCR5 Antibody	Human	ELISA, WB	CSB-PA572290
CCR5	Phospho-CCR5 (Ser349) Antibody	Human	ELISA, WB	CSB-PA942331
CD3D	CD3D Antibody	Human	ELISA, IHC	CSB-PA004930ESR1HU
CD3D	CD3D Antibody	Human	ELISA, WB	CSB-PA001452
CD3D	CD3D Antibody	Human	ELISA, WB	CSB-PA005826
CD3D	CD3D Antibody	Human, Mouse, Rat	ELISA, WB, IF	CSB-PA004930GA01HU

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● ELISA Kits

Bovine Interleukin 12,IL-12 ELISA Kit
CSB-E14010B

Goat interleukin 12,IL-12/P40 ELISA KIT
CSB-E12103G

Mouse Tumor necrosis factor α,TNF-α ELISA Kit
CSB-E04741m-IS

Human Tumor necrosis factor α,TNF-α ELISA KIT
CSB-E04598h

Target	Product Name	Sample Types	Detection Range	Code
CCL11	Human eosinophil chemotactic factor,ECF ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-E04533h
CCL11	Rat Eotaxin 1 (Eotaxin 1/CCL11/ECF)ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/ml -1000 pg/ml	CSB-E07319r
CCL20	Human Macrophage Inflammatory Protein-3α,MIP-3α ELISA kit	serum, plasma, cell culture supernates	15.6 pg/mL-1000 pg/mL	CSB-E04667h
CCL20	Mouse Macrophage Inflammatory Protein 3α,MIP-3α ELISA kit	serum, plasma, tissue homogenates	39 pg/ml - 2500 pg/ml	CSB-E04668m
CCL20	Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/ml - 10 ng/ml	CSB-E04669r
CD40	Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit		Request Information	CSB-EL004936MO
CD6	Mouse cluster of differentiation 6(CD6) ELISA Kit		Request Information	CSB-EL004949MO
CTLA4	Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	serum, plasma, tissue homogenates	125 pg/mL-8000 pg/mL	CSB-E09171h
CTLA4	Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E13637m
CXCL10	Human interferon-inducible protein 10,IP-10 ELISA Kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-E08181h
CXCL10	Rat interferon-inducible protein 10,IP-10 ELISA Kit	serum, plasma, tissue homogenates	781.25 pg/mL-50000 pg/mL	CSB-E08182r
CXCL10	Mouse interferon-inducible protein 10,IP-10 ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/ml - 20 ng/ml	CSB-E08183m
CXCL10	Monkey C-X-C motif chemokine 10(CXCL10) ELISA kit	serum, plasma, tissue homogenates	62.5 pg/mL-4000 pg/mL	CSB-EL006240RH
IL12A	Bovine Interleukin 12,IL-12 ELISA Kit	serum, plasma, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E14010B
IL12B	Human Interleukin 12,IL-12/P40 ELISA KIT	serum, plasma, tissue homogenates	0.156 ng/ml-10 ng/ml	CSB-E04598h
IL12B	Mouse interleukin 12,IL-12/P40 ELISA KIT	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E07360m
IL12B	Pig Interleukin 12,IL-12/P40 ELISA KIT	serum, plasma, cell culture supernates	15.6 pg/mL-1000 pg/mL	CSB-E11341p
IL12B	Goat interleukin 12,IL-12/P40 ELISA KIT	serum, plasma, tissue homogenates, cell lysates	9.38 pg/mL-600 pg/mL	CSB-E12103G
IL13	Human Interleukin 13,IL-13 ELISA KIT	serum, plasma, tissue homogenates	0.39 ng/ml-25 ng/ml.	CSB-E04601h
IL13	Mouse Interleukin 13,IL-13 ELISA Kit	serum, plasma, tissue homogenates	78 pg/ml - 5000 pg/ml	CSB-E04602m

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Click to view CUSABIO Cytokine ELISA kits

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