Systemic Sclerosis Overview & Premium Reagents

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by vascular abnormalities, immune activation, and progressive multi-organ fibrosis. Its core pathological mechanisms include autoantibody-mediated B-cell dysregulation, endothelial injury-induced vasculopathy, and fibroblast activation leading to excessive collagen deposition, ultimately causing fibrosis in organs such as the skin, lungs, and heart. Clinically, it is classified into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc), with the latter progressing rapidly, having a poor prognosis, and frequently complicated by interstitial lung disease (ILD) and myocardial fibrosis, resulting in high mortality.

Current Therapeutic Landscape and Research Focus

Current SSc management relies on immunosuppressants and antifibrotic agents, but efficacy remains limited without reversal of fibrosis. Recent research focuses on targeting pathogenic B cells, inflammatory pathways, and fibrosis reversal:

● Dual-target CAR-NK cell therapy (QN-139b): A groundbreaking therapy pioneered by Xu Huiji's team for dcSSc. It targets CD19/BCMA dual antigens, utilizing iPSC-derived CAR-NK cells to clear pathogenic B cells and plasma cells, thereby inducing immune reconstitution.

● JAK inhibitor (Baricitinib): Targets the JAK1/2 pathway to inhibit inflammatory cytokine signaling. Mechanistic studies indicate it downregulates the profibrotic factor IL-1RL1 (ST2) and upregulates the regeneration-associated protein SYT17.

Systemic Sclerosis Drug Targets in Development:

Systemic Sclerosis Drug Targets Related Products

● Target Proteins

CLEC4C
CSB-MP855470HUh7

Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody (CSB-RA855470MA1HU)，the EC₅₀ is 7.658-12.99 ng/mL.

IL13
CSB-MP6408HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 2.045-6.215 ng/mL.

IL1RAP
CSB-MP878844HU

Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP at 2 μg/ml can bind Anti-IL1RAP recombinant antibody (CSB-RA878844MA1HU). The EC₅₀ is 0.9667-1.477 ng/mL.

TNFSF13B
CSB-MP897523HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10 μg/ml can bind human BCMA (CSB-MP023974HU1), the EC₅₀ of human TNFSF13B protein is 221.3-298.6 ng/ml.

Target	Product Name	Source	Tag Info	Product Code
CCL24	Recombinant Human C-C motif chemokine 24 (CCL24)	E.coli	N-terminal 6xHis-tagged	CSB-EP004788HU
Ccl24	Recombinant Rat Chemokine (C-C motif) ligand 24 protein (Ccl24), partial (Active)	E.Coli	Tag-Free	CSB-AP001591RA
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	C-terminal 6xHis-tagged	CSB-CF004888HUc7
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005061HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated	Mammalian cell	C-terminal hFc1-Avi-tagged	CSB-MP004888HU-B
CLEC4C	Recombinant Human C-type lectin domain family 4 member C (CLEC4C), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP855470HU
CLEC4C	Recombinant Human C-type lectin domain family 4 member C (CLEC4C), partial (Active)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP855470HU
CLEC4C	Recombinant Human C-type lectin domain family 4 member C (CLEC4C), partial (Active)	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP855470HUh7
CLEC4C	Recombinant Macaca fascicularis C-type lectin domain family 4 member C (CLEC4C), partial (Active)	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP4819MOV
Ifnar1	Recombinant Mesocricetus auratus Interferon alpha/beta receptor 1 (Ifnar1), partial	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP5445MRG
IL13	Recombinant Human Interleukin-13 (IL13), partial	Mammalian cell	C-terminal hFc1-Myc-tagged	CSB-MP011590HU1
IL13	Recombinant Human Interleukin-13 (IL13)	Mammalian cell	C-terminal hFc1-tagged	CSB-MP011590HU
IL13	Recombinant Rhesus Macaque Interleukin-13 protein (IL13) (Active)	E.Coli	Tag-Free	CSB-AP003181MOW
IL13	Recombinant Human Interleukin-13 (IL13), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004321HU
Il13	Recombinant Mouse Interleukin-13 (Il13), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004751MO
Il13	Recombinant Mouse Interleukin-13 (Il13), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004761MO
Il13	Recombinant Mouse Interleukin-13 (Il13), partial (Active)	E.coli	Tag-Free	CSB-AP004771MO
IL13	Recombinant Human Interleukin-13 (IL13)	E.coli	N-terminal 6xHis-tagged	CSB-EP011590HU

● Antibodies

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

ITGAV Recombinant Monoclonal Antibody
CSB-RA279866A0HU

Tested Applications:
ELISA, WB, IHC

LGALS3 Recombinant Monoclonal Antibody
CSB-RA970289A0HU

Tested Applications:
ELISA, WB, IHC, IF, IP

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
CLEC4C	CLEC4C Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA855470MA1HU
IFNAR1	IFNAR1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011046A0HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA548303A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA279866A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA011877MA1HU
LGALS3	LGALS3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF, IP	CSB-RA970289A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU
RAF1	Phospho-RAF1 (S621) Recombinant Monoclonal Antibody	Human	ELISA, WB, IF	CSB-RA019284A621phHU
RAF1	Phospho-RAF1 (S259) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF	CSB-RA019284A259phHU
RAF1	Phospho-RAF1 (S43) Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA019284A43phHU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
LGALS3	LGALS3 Monoclonal Antibody	Human, Mouse	ELISA, WB, IHC	CSB-MA0128871A0m
LGALS3	LGALS3 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA000198
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CCL24	CCL24 Antibody	Human	ELISA, IHC	CSB-PA05909A0Rb
CCL24	CCL24 Antibody	Human	ELISA, WB	CSB-PA272302
CD19	CD19 Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA001431
CD19	Phospho-CD19 (Y531) Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA070286
CD19	CD19 Antibody	Human	ELISA, WB	CSB-PA006159
CD19	CD19 (Ab-531) Antibody	Human, Mouse	ELISA, WB	CSB-PA253616
CD19	Phospho-CD19 (Tyr531) Antibody	Human, Mouse	ELISA, WB	CSB-PA058389
CLEC4C	CLEC4C Antibody	Human	ELISA, IHC	CSB-PA855470LA01HU
CLEC4C	CLEC4C Antibody	Human	ELISA, IHC	CSB-PA273524
CLEC4C	CLEC4C Antibody	Human	ELISA, IHC	CSB-PA640573
IFNAR1	Phospho-IFNAR1 (Y466) Antibody	Human	ELISA, WB, IHC	CSB-PA009471
IFNAR1	IFNAR1 Antibody	Human	ELISA, IHC, IF	CSB-PA009473
IFNAR1	IFNAR1 Antibody	Human	ELISA, IHC	CSB-PA107635
IFNAR1	IFNAR1 Antibody	Human	ELISA, WB	CSB-PA011046GA01HU
IFNAR1	Phospho-IFNAR1 (Ser535/Ser539) Antibody	Human	ELISA, WB	CSB-PA041971
IL13	IL13 Antibody	Human	ELISA, IHC, IF	CSB-PA011590LA01HU
IL13	IL13 Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA011590KA01HU
IL17RA	IL17RA Antibody	Human, Mouse	ELISA, WB, IF	CSB-PA12929A0Rb
IL17RA	IL17RA Antibody	Human, Mouse	ELISA, WB	CSB-PA008440
IL17RA	IL17RA Antibody	Human	ELISA, IHC	CSB-PA032717

● ELISA Kits

Human Transforming Growth factor β1,TGF-β1 ELISA kit
CSB-E04725h

Mouse Interleukin 13,IL-13 ELISA Kit
CSB-E04602m

Rat toll-like receptor 4 (TLR4) ELISA Kit
CSB-E15822r

Human Protein S100-A4(S100A4) ELISA kit
CSB-EL020632HU

Target	Product Name	Sample Types	Detection Range	Code
CCL24	Mouse Eotaxin 2 ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/ml - 1000 pg/ml	CSB-E07278m
CCL24	Human Eotaxin 2/CCL24 ELISA Kit	serum, plasma, tissue homogenates	78.125 pg/mL-5000 pg/mL	CSB-E10360h
IL13	Mouse Interleukin 13,IL-13 ELISA Kit	serum, plasma, tissue homogenates	78 pg/ml - 5000 pg/ml	CSB-E04602m
IL13	Rat Interleukin 13,IL-13 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	7.8 pg/mL-500 pg/mL	CSB-E07454r
IL13	Human Interleukin 13,IL-13 ELISA KIT	serum, plasma, tissue homogenates	0.39 ng/ml-25 ng/ml.	CSB-E04601h
IL13	Dog Interleukin-13(IL13) ELISA kit	serum, plasma, tissue homogenates	12.5 pg/mL-800 pg/mL	CSB-EL011590DO
IL17RA	Human Interleukin-17 receptor A(IL17RA) ELISA kit	serum, plasma, tissue homogenate	39 pg/ml-2500 pg/ml	CSB-EL011602HU
IL23A	Human Interleukin-23 subunit alpha(IL-23A) Elisa kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	62.5 pg/mL-4000 pg/mL	CSB-E17339h
IL23A	Pig Interleukin-23 subunit alpha(IL23A) ELISA kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-EL011638PI
IL31RA	Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit	serum, plasma, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-EL011654HU
IL6R	Human Interleukin 6 receptor(IL-6R)ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E16524h
IL6R	Rat Interleukin 6 receptor,IL-6R ELISA Kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-E11876r
LGALS3	Human lectin-galactose binding-soluble 3,Lgals3 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, saliva	0.625 ng/mL-40 ng/mL	CSB-E11807h
LGALS3	Mouse Galectin 3(GAL-3) ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E14296m
LGALS3	Rat Galectin-3(LGALS3) ELISA kit	serum, plasma, tissue homogenates	1.56 ng/mL-100 ng/mL	CSB-EL012887RA
MS4A1	Human B-lymphocyte antigen (CD20) ELISA Kit	serum, plasma, tissue homogenates	3.12 ng/mL-200 ng/mL	CSB-E14007h
PDCD1	Human Programmed Death 1(PD-1)ELISA KIT	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E13643h
PDCD1	Mouse Programmed Death 1(PD-1)ELISA Kit	serum, plasma, tissue homogenates, cell lysates	0.312 ng/mL-20 ng/mL	CSB-E13586m
S100A4	Human Protein S100-A4(S100A4) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.9 ng/mL-60 ng/mL	CSB-EL020632HU
S100A4	Mouse Protein S100-A4(S100A4) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	62.5 pg/mL-4000 pg/mL	CSB-EL020632MO