Top Dermatomyositis Drug Targets & Emerging Therapies Research

Dermatomyositis (DM) is an autoimmune connective tissue disorder affecting the skin and skeletal muscles, typically presenting with subacute or chronic onset. Its etiology remains unclear and may involve factors such as autoimmunity, infections, malignancies, and genetics. The annual incidence of adult dermatomyositis is 5-10 per million, with a male-to-female ratio of approximately 1:2. The age of onset exhibits a bimodal distribution, peaking in childhood (5-15 years) and among adults aged 45-65 years.

Clinically, DM primarily manifests as skin and muscle involvement, including characteristic signs such as heliotrope rash, Gottron's papules, and symmetric proximal limb muscle weakness with neck flexor weakness. Some patients may also develop complications such as malignancies or interstitial lung disease.

In recent years, novel therapies for dermatomyositis have emerged. Biologics have become a major focus of research, with agents targeting specific cytokines or immune pathways—such as anti-interleukin-6 receptor antagonists—demonstrating therapeutic potential. For instance, in refractory juvenile dermatomyositis (JDM), an analysis of 458 patients treated with rituximab showed that 78.3% experienced improvement in skin and muscle symptoms. Most patients exhibited positive changes in myositis-specific autoantibody profiles without symptom relapse. Additionally, small-molecule targeted therapies are under investigation. Among JAK inhibitors, tofacitinib was the first drug in this class approved by FDA for autoimmune diseases. Multiple case reports confirm its efficacy in severe skin disease and refractory DM, improving skin rash, joint pain, and muscle strength while reducing corticosteroid dependence. In February 2025, a study led by Professor Ye Shuang's team from the Rheumatology Department of Renji Hospital affiliated with Shanghai Jiao Tong University School of Medicine demonstrated that tofacitinib, as an initial immunosuppressive regimen, significantly improved 1-year transplant-free survival in anti-MDA5-positive DM patients with interstitial lung disease compared to calcineurin inhibitors.

Dermatomyositis Drug Targets in Development:

Dermatomyositis Drug Targets Related Products

● Target Proteins

CD7
CSB-MP004953HU

Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC₅₀ is 1.236-1.773 ng/ml.

GLP1R
CSB-MP009514HUb1

Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.

IL6
CSB-EP011664HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.1518 - 0.3987 ng/mL.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

Target	Product Name	Source	Tag Info	Product Code
C5	Recombinant Human Complement C5 (C5), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003995HU
C5	Recombinant Rat Complement C5 (C5)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003995RA
C5	Recombinant Human Complement C5 (C5), partial	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP003995HU
C5	Recombinant Pig Complement C5a anaphylatoxin (C5)	Yeast	N-terminal 6xHis-tagged	CSB-YP003995PI
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	C-terminal 6xHis-tagged	CSB-CF004888HUc7
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005061HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated	Mammalian cell	C-terminal hFc1-Avi-tagged	CSB-MP004888HU-B
CD6	Recombinant Human T-cell differentiation antigen CD6(CD6), partial	Yeast	C-terminal 6xHis-Myc-tagged	CSB-YP326953HU
CD6	Recombinant Human T-cell differentiation antigen CD6(CD6), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP326953HUa0
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP004953HU
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004953HU
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	Mammalian cell	C-terminal hFc1-Myc-tagged	CSB-MP004953HU
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004953HUb1
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial, Biotinylated	Mammalian cell	C-terminal mFc-Avi-tagged	CSB-MP004953HU-B
Cfb	Recombinant Mouse Complement factor B (Cfb)	E.coli	N-terminal 6xHis-tagged	CSB-EP005268MO
Cfb	Recombinant Mouse Complement factor B (Cfb)	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP005268MO
Cfb	Recombinant Mouse Complement factor B (Cfb)	E.coli	C-terminal 6xHis-tagged	CSB-EP005268MOc7
CGAS	Recombinant Human Cyclic GMP-AMP synthase (CGAS), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP822726HU

● Antibodies

C5 Recombinant Monoclonal Antibody
CSB-RA003995MA1HU

Tested Applications:
ELISA, FC

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody
CSB-RA011931A100phHU

Tested Applications:
ELISA, WB, IHC, IP

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
C5	C5 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA003995MA1HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
GLP1R	GLP1R Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA009514MA1HU
IFNAR1	IFNAR1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011046A0HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
JAK1	JAK1 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA227790A0HU
JAK2	Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA011931A100phHU
JAK2	JAK2 Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA267127A0HU
JAK3	JAK3 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA206737A0HU
LTA	LTA Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA013218A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
NR3C1	NR3C1 Recombinant Monoclonal Antibody	Human	ELISA, WB, FC	CSB-RA958910A0HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU
S1PR1	S1PR1 Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA923827A0HU
TLR7	TLR7 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA556665A0HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
JAK1	JAK1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA919964
JAK2	JAK2 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA181103
JAK2	JAK2 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA780030
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272
TNFRSF17	TNFRSF17 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA023974A0m
TNFRSF17	TNFRSF17 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA023974A1m

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
C5	C5 Antibody	Human	ELISA, IHC	CSB-PA003995LA01HU
C5	C5 Antibody	Pig	ELISA, IHC	CSB-PA003995YA01PI
CD19	CD19 Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA001431
CD19	Phospho-CD19 (Y531) Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA070286
CD19	CD19 Antibody	Human	ELISA, WB	CSB-PA006159
CD19	CD19 (Ab-531) Antibody	Human, Mouse	ELISA, WB	CSB-PA253616
CD19	Phospho-CD19 (Tyr531) Antibody	Human, Mouse	ELISA, WB	CSB-PA058389
CD6	CD6 Antibody	Human	ELISA, WB, IHC	CSB-PA326953ESR1HU
CD6	CD6 Antibody	Human	ELISA, IHC	CSB-PA326953ESR2HU
CD6	CD6 Antibody	Human	ELISA, WB	CSB-PA006156
CD6	CD6 Antibody	Human	ELISA, WB	CSB-PA070265
CD6	CD6 Antibody	Human	ELISA, WB	CSB-PA134350
CD7	CD7 Antibody	Human	ELISA, IHC	CSB-PA004953YA01HU
CD7	CD7 Antibody	Human	ELISA, IHC	CSB-PA004953ESR1HU
CD7	CD7 Antibody	Human	ELISA, WB	CSB-PA005197
CFB	CFB Antibody	Human	ELISA, WB, IHC	CSB-PA11049A0Rb
Cfb	Cfb Antibody	Mouse, Human	ELISA, WB	CSB-PA005268LA01MO
CFB	Cleaved-CFB (K260) Antibody	Human, Mouse	ELISA, WB	CSB-PA040288
CFB	CFB Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA005268GA01HU
CNR2	CNR2 Antibody	Human	ELISA, IHC, IF	CSB-PA005679LA01HU

● ELISA Kits

Rat TNF-α ELISA kit
CSB-E11987r

Mouse Interferon β,IFN-β/IFNB ELISA Kit
CSB-E04945m

Mouse Tumor necrosis factor β,TNF-β ELISA KIT
CSB-E04744m

Bovine Interleukin 12,IL-12 ELISA Kit
CSB-E14010B

Target	Product Name	Sample Types	Detection Range	Code
TNF	Rat TNF-α ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E11987r
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/ml-1000 pg/ml	CSB-E04741m
TNF	Human Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	7.8 pg/mL-500 pg/mL	CSB-E04740h
TNF	Bovine TNF-αELISA kit	serum, plasma, tissue homogenates	0.1 ng/mL-20 ng/mL	CSB-E12020B
TNF	Rabbit Tumor necrosis factor α,TNFα ELISA Kit	serum, plasma, tissue homogenates, cell lysates	78 pg/mL-5000 pg/mL	CSB-E06998Rb
IFNB1	Mouse Interferon β,IFN-β/IFNB ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E04945m
IFNB1	Human Interferon β,IFN-β/IFNB ELISA Kit	serum, urine, cell culture supernates, tissue homogenates, cerebrospinal fluid (CSF)	31.25 pg/mL-2000 pg/mL	CSB-E09889h
TNF	Pig Tumor necrosis factor (TNF/TNFA/TNFSF2) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.047 ng/mL-3 ng/mL	CSB-E16980p
TNF	Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates	3.12 pg/mL-200 pg/mL	CSB-E06772Gu
TNF	Sheep Tumor Necrosis Factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates	3.125 pg/mL-50 pg/mL	CSB-E13853Sh
TNF	Goat Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E09811g
LTA	Mouse Tumor necrosis factor β,TNF-β ELISA KIT	serum, plasma, tissue homogenates	18.75 pg/mL-1200 pg/mL	CSB-E04744m
IL12A	Bovine Interleukin 12,IL-12 ELISA Kit	serum, plasma, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E14010B
PDCD1	Human Programmed Death 1(PD-1)ELISA KIT	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E13643h
NR3C1	Rat glucocorticoid receptor,GR ELISA Kit	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E08747r
LTA	Human Tumor necrosis factor β,TNF-β ELISA KIT	serum, plasma, cell culture supernates	15.6 pg/mL-1000 pg/mL	CSB-E04743h
IFNB1	Rat Interferon β,IFN-β/IFNB ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04845r
IFNB1	Bovine Interferon β,IFN-β/IFNB ELISA Kit		Request Information	CSB-E13699B
TNF	Horse Tumor necrosis factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E14031Hs
CFB	Human factor B,BF ELISA Kit	serum, plasma	1.56 ng/mL-100 ng/mL	CSB-E09447h