Multiple Sclerosis Research Tools | Proteins, Antibodies & ELISA Kits

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) characterized by a multifocal distribution of white matter in the CNS and remission relapses during the course of the disease, usually involving periventricular white matter, optic nerves, the spinal cord, the brainstem, and the cerebellum.

The pathologic features of multiple sclerosis include inflammatory cell infiltration, neuronal degeneration, axonal damage, and reactive gliosis. Clinical symptoms vary from person to person and may include visual and motor nerve abnormalities, sensory abnormalities, weakness, spasticity, urinary dysfunction, and mild cognitive symptoms, the severity and type of which depend on the areas of the brain and spinal cord affected. Globally, the prevalence of MS is about 3/100,000 with about 3.5 million patients.

Therapeutic drugs for multiple sclerosis mainly include immunosuppressants and immunomodulators, which are able to alleviate the symptoms and slow down the progression of the disease to a certain extent, but it is still difficult to achieve myelin regeneration and neuronal regeneration. The main drug development targets are listed below:

CD20 (MS4A1): CD20 is a marker on the surface of B cells and their precursor cells. By targeting CD20, antibody-dependent cytotoxicity and complement-mediated cytotoxicity can be induced, thereby removing B cells and attenuating the inflammatory response to MS. Ocrelizumab is a monoclonal antibody analog that targets CD20 to clear B cells. Clinical trials have shown significant efficacy of Ocrelizumab in relapsing or primary progressive MS.
CD40L (CD40LG): In MS, aberrant activation of the CD40/CD40L pathway may result in the immune system mistakenly attacking the myelin sheaths of the central nervous system, thereby triggering inflammation and injury.CD40L plays an important role in regulating the interactions of T-cells with other immune cells, particularly B-cells and antigen-presenting cells, through its interactions with its receptor, CD40. Frexalimab is a monoclonal antibody targeting CD40L that blocks the co-stimulatory CD40/CD40L cell pathway necessary for the activation and function of adaptive (T and B cells) and innate (macrophages and dendritic cells) immune cells without depleting lymphocytes, and has already achieved positive clinical results. achieved positive clinical results.
IL17A: IL-17A, as a pro-inflammatory factor, recruits immune cells to the site of inflammation by inducing the expression of chemokines and produces a synergistic effect with other cytokines, such as TNF and IL-22, which together contribute to the exacerbation of the inflammatory response. In MS, this inflammatory response may lead to the destruction of myelin in the central nervous system, which in turn triggers a series of clinical symptoms. In addition, IL-17A may further exacerbate neurological damage by affecting the activity and function of glial cells. Secukinumab is an IL-17A inhibitor that inhibits IL-17A-mediated inflammatory responses by specifically binding to IL-17A and blocking its interaction with its receptor. Studies have shown that Secukinumab significantly reduces disease activity, decreases the number of emerging inflammatory lesions, and improves clinical symptoms in patients with MS.
IL7R: Activation of IL-7 signaling promotes T cell expansion and increases the proliferation of autoantigens, leading to autoimmune susceptibility. In MS patients, the expression level of IL-7R is usually high. By inhibiting the function of IL-7R, the IL-7 signaling pathway can be blocked, thus inhibiting T cell expansion and autoimmune response, and achieving the purpose of treating MS. Currently, in addition to anti-IL-7R monoclonal antibody ( Crebankitug ), other inhibitors targeting the IL-7/IL-7R signaling pathway are under development. These drugs may inhibit the activation of the IL-7 signaling pathway through different mechanisms, thus providing more diverse therapeutic options for MS patients.
CD52: CD52 is a marker on the surface of monocytes and lymphocytes. Monoclonal antibodies against CD52 deplete T, B, and NK cells, especially CD4+ T cells, thereby reducing the inflammatory response in MS. Alemtuzumab is a monoclonal antibody against CD52 that depletes T, B, and NK cells. Clinical trials have shown that Alemtuzumab significantly reduces the annual relapse rate compared to interferon, but has a similar rate of disability progression. However, alemtuzumab has serious adverse effects, especially secondary to autoimmune disease.

Others such as CD49d (ITGA4), RGMA, CXCL13, CD4, CD6 are also important targets for MS drug development. Drugs against these targets are also in clinical development and have shown some efficacy.

CUSABIO has long been committed to providing researchers with high-quality proteins, antibodies, ELISA kits and other tools for scientific research reagents, and has compiled a series of popular targets related to multiple sclerosis research and related reagent products listed below for your selection:

Multiple Sclerosis Drug Targets in Development:

Multiple Sclerosis Drug Targets Related Products

● Target Proteins

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

CD40
CSB-MP004936HU1

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC₅₀ is 2.353-3.232 ng/ml.

CD40LG
CSB-MP004937HU3

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC₅₀ is 2.353-3.232 ng/ml.

IL17A
CSB-BP624104HU(M)

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC₅₀ is 1.818-2.170 ng/mL.

IL2RA
CSB-MP011649HU3

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL.

SEMA4D
CSB-MP835707HUd9

Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 2 μg/ml can bind biotinylated Pepinemab, the EC₅₀ is 1.005-1.776 ng/mL

TNFSF13B
CSB-MP897523HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

Target	Product Name	Source	Tag Info	Product Code
Ccr2	Recombinant Mouse C-C chemokine receptor type 2 (Ccr2), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004841MO1
CCR7	Recombinant Human C-C chemokine receptor type 7 (CCR7), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004846HU1
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	C-terminal 6xHis-tagged	CSB-CF004888HUc7
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005061HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated	Mammalian cell	C-terminal hFc-Avi-tagged	CSB-MP004888HU-B
CD22	Recombinant Human B-cell receptor CD22 (CD22), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP004900HU1
CD22	Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-MP004900HU
CD22	Recombinant Human B-cell receptor CD22 (CD22), partial, Biotinylated	Mammalian cell	C-terminal 6xHis-Avi-tagged	CSB-MP004900HU-B
CD3E	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP004931HU
CD3E	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E)	E.coli	N-terminal GST-tagged	CSB-EP004931HU(A4)
CD3E	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004931HU
Cd3e	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004931MO
Cd3e	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004931MO
CD3E	Recombinant Pig T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP801781PI
Cd3e	Recombinant Mesocricetus auratus T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	E.coli	N-terminal 6xHis-tagged and C-terminal Strep II-tagged	CSB-EP4828MRG
CD3E	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Mammalian cell	C-terminal hFc-tagged	CSB-MP004931HU
Cd3e	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	E.coli	C-terminal 6xHis-tagged	CSB-EP004931MOc7
CD4	Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004935HU1

● Antibodies

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Tested Applications:
ELISA, IF, FC

CD146 Recombinant Monoclonal Antibody
CSB-RA013563A0HU

Tested Applications:
ELISA, WB, IHC, IF, FC

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC

- Recombinant Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CCR2	CCR2 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA297464A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
CD22	CD22 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA962691A0HU
CD3E	CD3E Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA004931MA1HU
CD4	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA004935A0HU
CD40	CD40 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA004936MA1HU
IL17A	IL17A Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA624104MA1HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
IL2RA	IL2RA Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA011649MA1HU
ITGA4	ITGA4 Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA225859A0HU
ITGAL	ITGAL Recombinant Monoclonal Antibody	Human	ELISA, WB, IF	CSB-RA787996A0HU
MCAM	CD146 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-RA013563A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU
PDGFRB	Phospho-PDGFRB (Y740) Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA017713A740phHU
PDGFRB	PDGFRB Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA213932A0HU
SEMA4D	SEMA4D Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA835707A1HU
SEMA4D	SEMA4D Recombinant Monoclonal Antibody	Human, Mouse	ELISA, FC	CSB-RA835707A2HU

- Monoclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
CD3E	CD3E Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA028904
CD3E	CD3E Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA063709
CD3E	CD3E Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA270849
CD3E	CD3E Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA634374
CD3E	CD3E Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA843517
CD3E	CD3E Monoclonal Antibody,Purified	Human	ELISA, IF, FC	CSB-MA947479
CD3E	CD3E Monoclonal Antibody,FITC/PE Conjugated	Human	ELISA, IF, FC	CSB-MA920656
CD3E	CD3E Monoclonal Antibody,FITC/PE Conjugated	Human	ELISA, IF, FC	CSB-MA252451
CD3E	CD3E Monoclonal Antibody,FITC/PE/PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA566015
CD3E	CD3E Monoclonal Antibody,FITC/PE Conjugated	Human	ELISA, IF, FC	CSB-MA782605
CD3E	CD3E Monoclonal Antibody,FITC/PE Conjugated	Human	ELISA, IF, FC	CSB-MA087211
CD3E	CD3E Monoclonal Antibody,FITC/PE Conjugated	Human	ELISA, IF, FC	CSB-MA157951

- Polyclonal Antibody

Target	Product Name	Species Reactivity	Tested Applications	Code
BST1	BST1 Antibody	Human, Mouse	ELISA, WB, IHC	CSB-PA734093ESR2HU
BST1	BST1 Antibody	Human, Mouse, Rat, Monkey	ELISA, WB	CSB-PA001059
BST1	BST1 Antibody	Human	ELISA, WB	CSB-PA005863
BST1	BST1 Antibody	Human, Mouse, Rat	ELISA, IHC	CSB-PA159485
BST1	BST1 Antibody	Human, Mouse, Rat	ELISA, IHC	CSB-PA796533
BST1	BST1 Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA052030
CCR2	CCR2 Antibody	Human	ELISA, IF	CSB-PA004841LA01HU
Ccr2	CCR2 Antibody	Mouse, Rat	ELISA, WB, IF	CSB-PA006349
CCR2	CCR2 Antibody	Human	ELISA, WB	CSB-PA006295
CCR2	CCR2 Antibody	Human	ELISA, WB	CSB-PA004841GA01HU
CCR2	CCR2 Antibody	Human, Mouse	ELISA, WB, IHC	CSB-PA171419
CCR7	CCR7 Antibody	Human	ELISA, IHC, IF	CSB-PA004846LA01HU
CCR7	CCR7 Antibody	Human, Monkey	ELISA, WB, IF	CSB-PA006996
CCR7	CCR7 Antibody	Human	ELISA, WB	CSB-PA265889
CD19	CD19 Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA001431
CD19	Phospho-CD19 (Y531) Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA070286
CD19	CD19 Antibody	Human	ELISA, WB	CSB-PA006159
CD19	CD19 (Ab-531) Antibody	Human, Mouse	ELISA, WB	CSB-PA253616
CD19	Phospho-CD19 (Tyr531) Antibody	Human, Mouse	ELISA, WB	CSB-PA058389
CD22	CD22 Antibody	Human	ELISA, IHC	CSB-PA004900ESR1HU

● ELISA Kits

Target	Product Name	Sample Types	Detection Range	Code
CCR2	Rat C-C chemokine receptor type 2(CCR2) ELISA kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-EL004841RA
CCR2	Human CC-Chemokine Receptor 2,CCR2 ELISA Kit	serum, plasma, tissue homogenates, cerebrospinal fluid (CSF)	23.44 pg/mL-1500 pg/mL	CSB-E14200h
CCR2	Mouse C-C chemokine receptor type 2(CCR2) ELISA kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-EL004841MO
CD4	Rat cluster of differentiation 4,CD4 ELISA Kit	serum, plasma, tissue homogenates	0.78 U/mL-50 U/mL	CSB-E12928r
CD4	Human cluster of differentiation 4,CD4 ELISA Kit	serum, plasma	0.625 ng/mL-40 ng/mL	CSB-E08956h
CD4	Chicken Cluster of Differentiation 4(CD4) ELISA Kit	serum, plasma, tissue homogenates	3.125 ng/mL-800 ng/mL	CSB-E13114C
CD40	Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit		Request Information	CSB-EL004936MO
CD40LG	Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E04716h
CD40LG	Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	serum, plasma, tissue homogenates	1.87 ng/mL-120 ng/mL	CSB-E07395r
CD40LG	Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates.	0.274 ng/ml-200 ng/ml.	CSB-E04717m
CD52	Human CAMPATH-1 antigen(CD52) ELISA kit	serum, plasma, tissue homogenates, cell lysates	78 ng/mL-5000 ng/mL	CSB-EL004943HU
CD6	Mouse cluster of differentiation 6(CD6) ELISA Kit		Request Information	CSB-EL004949MO
CSF2	Mouse Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04569m
CSF2	Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04568h
CSF2	Rat Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/ml - 1000 pg/ml	CSB-E04570r
CXCL13	Human B-Lymphocyte Chemoattractant 1,BLC-1 ELISA Kit	serum, plasma, tissue homogenates	78 pg/mL-5000 pg/mL	CSB-E10019h
CXCL13	Mouse C-X-C motif chemokine 13 (Cxcl13/Blc/Scyb13) ELISA kit	serum, plasma, tissue homogenates, cell culture supernates	0.156 ng/mL-10 ng/mL	CSB-E16832m
ENO1	Human Alpha-enolase (ENO1/ENO1L1/MBPB1/MPB1) ELISA kit	serum, tissue homogenates, plasma	0.312 ng/mL-20 ng/mL	CSB-E17177h
ENO1	Rat α-enolase ELISA Kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-E17439r
ENO1	Mouse Alpha-enolase(ENO1) ELISA kit	serum, plasma, tissue homogenates	62.5 pg/mL-4000 pg/mL	CSB-EL007670MO