Mouse Acetylcholinesterase(AChE)ELISA Kit

1. Results indicate that direct inhibition of acetylcholinesterase activity and up-regulation of m1 muscarinic acetylcholine receptor expression in the striatum might contribute to the beneficial effects of alpha-asarone on locomotor hyperactivity in Fmr1 knock out mice. PMID: 27316341
2. Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt/mTOR pathway in APP/PS1 transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease. PMID: 27737765
3. Results indicate that adult onset hypothyroidism caused significant memory impairment and increased fear/anxiety. Moreover, the activity of both isoforms of AChE was reduced in all brain regions examined in a brain region- and isoform-specific manner. PMID: 27317840
4. Unusually high AChE activity may be an effect marker of exposure to ethanol. The relationship between AChE and apoptosis might represent a novel mechanism of ethanol-associated neuronal injury. PMID: 28427893
5. Findings suggested the role of DNA methylation on acetylcholinesterase transcriptional regulation and provided insight in elucidating the DNA methylation-mediated regulatory mechanism on acetylcholinesterase expression during muscle differentiation. PMID: 27021952
6. Nerolidol-loaded nanospheres reverse memory impairment and to prevent increased ROS and TBARS levels due to amelioration of Na(+), K(+)-ATPase and AChE activities and to activation of the antioxidant enzymes, respectively. PMID: 27807596
7. the amounts of AChE activity, AChE catalytic subunit, structure subunit PRiMA and the amount of acetylcholine, in the brain were not, significantly, altered, suggesting the role of P2Y1R in neuron could have different function as that in muscle. PMID: 27378627
8. In P2Y1R (-/-) mice, acetylcholinesterase expression in muscle was markedly decreased. The proline-rich membrane anchor subunit was reduced by 60 %; while the collagen tail subunit was reduced by 50 %. AChE molecular forms in the muscle were not changed. PMID: 26036470
9. Our results are discussed in the context of AChE inhibitor therapy as used in dementia. PMID: 26506622
10. Reduction of AChE levels in prion-infected heterozygous AChE knock-out mice leads to slightly but significantly prolonged incubation time. PMID: 25853328
11. mRNA expressions of brain specific fatty acid protein 7 (fabp-7) and phospholipase A2 group IV (pla2g4) were significantly downregulated in AChE-deficient mice. PMID: 24573602
12. In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE. PMID: 24312449
13. AChE is regulated in two neuronal cell lines by APP in a manner independent of the generation of sAPPalpha, sAPPbeta, and AICD. PMID: 23897820
14. Deficiency or inhibition of acetylcholinesterase can decrease apoptosis and protect dopaminergic neurons in the neurotoxin model of Parkinson's disease. PMID: 23201480
15. Attribute stress-inducible cognitive impairments to cholinergic-mediated induction of miR-132 and consequently suppressed synaptic ACHE. PMID: 22246100
16. assayed the relative activities of AChE and BChE in membrane fractions and culture medium of three different neuronal cell lines, namely the neuroblastoma cell lines SH-SY5Y and NB7 and the basal forebrain cell line SN56 PMID: 23047022
17. Long-lasting stress-inducible changes in AChE's promoter choices, identify the chromatin changes that support this long-term transcriptional memory, and reveal HDAC4 as a mediator of these effects in the hippocampus. PMID: 23236169
18. binding of AChE to laminin-1 alters AChE activity and leads to increased neurite growth in culture. A possible mechanism of the AChE effect on neurite outgrowth is proposed due to the interaction of AChE with laminin-1. PMID: 22570738
19. The reduction of muscle end-plate AChE activity early during the onset of STZ-induced hyperglycemia may contribute to endplate pathology and subsequent muscle weakness during diabetes. PMID: 22739110
20. Acetylcholinesterase is associated with apoptosis in beta cells and contributes to insulin-dependent diabetes mellitus pathogenesis PMID: 22236578
21. Report effects of K074 and pralidoxime on antioxidant response and acetylcholinesterase reactivation in malathion-poisoned mice. PMID: 21723318
22. Brain acetylcholinesterase activity in Dst(dt-J) mutants, revealed increases in the neostriatum, the habenula-interpeduncular pathway, the cholinergic pedunculopontine nucleus and its target structures. PMID: 21978551
23. Dietary restriction regulates brain acetylcholinesterase in female mice as a function of age. PMID: 21870149
24. PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse. PMID: 21865157
25. Electrophysiological and ultrastructural studies were performed on phrenic nerve-hemidiaphragm preparations isolated from wild-type and acetylcholinesterase (AChE) knockout (KO) mice. PMID: 21538119
26. Results confirm the results of previous molecular dynamics simulations, expand the view and suggest the probable reasons for the overall conformational behavior of AChE omega loop. PMID: 20919754
27. AChE activity is present both in the primary cleft and in the secondary folds, whereas BChE activity appears to be almost absent in the primary cleft and to be concentrated in subsynaptic folds. PMID: 20805581
28. the function and localization of AChE in mammalian systems PMID: 20153304
29. RNA expression profiles of the muscles of AChE knockout mice compared with those of the wild-type siblings PMID: 20381477
30. AChE may be a pro-apoptotic factor and the inhibition of AChE reduces renal ischemia-reperfusion injury. PMID: 20054652
31. these findings identify the AChE mRNA-targeting miR-132 as a functional regulator of the brain-to-body resolution of inflammation. PMID: 20005135
32. neuronal hypersensitivity under stress involves neuritic replacement of acetylcholinesterase-S with acetylcholinesterase-R PMID: 11799248
33. The effects of porphyrinogenic drugs on the brain cholinergic system (Ache, Bche, and Chrm1 levels in various regions of the brain) were examined to establish a mechanism for neurological syndrome displayed in acute porphyrias. PMID: 11929041
34. regulation of ACHE expression in developing muscle cells PMID: 12140295
35. Inhibitors of different structure induce distinguishing conformations in the omega loop. PMID: 12196517
36. ligand interactions of the enzyme at the peripheral anionic site PMID: 12505979
37. Interaction with RACKq and PKCbeta II correlates with intensified fear-induced conflict behavior PMID: 12509514
38. an analysis of the active site and conformation PMID: 12665427
39. fluctuations of the Omega loop residues are not tightly coupled and residues in the Omega loop exhibit distinctive conformational fluctuations and therefore are likely to contribute to transient gorge enlargements in the non-liganded enzyme. PMID: 12759360
40. Acetylcholinesterase[AChE] histochemistry revealed an abnormal distribution of AChE-positive cells in several areas of the reeler brain, including cortices; the strongest labelling was observed in cerebellum and hippocampus when compared with controls PMID: 14535959
41. primary role for stress-induced alternative splicing of the AChE gene to elevated contextual fear and synaptic plasticity, and the AChE-R splice variant has a major role in this process. PMID: 14581933
42. Molecular modeling studies suggest that E2020 interacts with the active-site and the peripheral anionic site in AChE PMID: 14622273
43. Data suggest that alternative promoter usage combined with alternative splicing may lead to stress-dependent combinatorial complexity of acetylcholinesterase mRNA transcripts and their protein products. PMID: 15123727
44. Data describe up-regulation of acetylcholinesterase activity and compensatory down-regulation of M2 muscarinic receptors in the striatal caudate putamen and nucleus accumbens of mu-opioid receptor knockout mice. PMID: 15207914
45. biophysical diffusion reaction rate calculations of wild-type and mutant mouse acetylcholinesterase PMID: 15345536
46. AChE is involved in regulating cell-matrix interactions in bone PMID: 15454088
47. Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors. PMID: 15579149
48. HuR interacts with the AChE 3'-UTR to regulate posttranscriptionally the expression of AChE mRNA during myogenic differentiation PMID: 15878846
49. structural studies of active center gorge of AChe PMID: 16259971
50. neuromuscular system exhibits a remarkable plasticity and adaptive responses to the chronic absence of AChE activity that has important consequences for the functioning of the neuromuscular junction PMID: 16274683

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KEGG: mmu:11423

STRING: 10090.ENSMUSP00000024099

UniGene: Mm.255464