Myc Antibody

Code CSB-PA894777XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Myc Polyclonal antibody
Uniprot No.
Target Names
Myc
Alternative Names
Myc antibody; dm antibody; CG10798 antibody; Myc protein antibody; Diminutive protein antibody; dMyc1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Myc protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiquitin-protein ligase member archipelago (ago) which functions in its degradation. It may therefore create a negative feedback loop with ago that is regulated by the ubiquitin hydrolase puf.
Gene References into Functions
  1. tissue specific downregulation of dMyc (Drosophila homolog of human c-myc proto-oncogene) alleviates h-tau mediated cellular and functional deficits by restricting the formation of NFTs in neuronal tissues. PMID: 28529046
  2. Expression of Drosophila Myc (dMyc) suppresses, whereas loss of dMyc enhances, ectopically activated JNK signaling-induced cell death. dMyc impedes physiologically activated JNK pathway-mediated cell death. Loss of dMyc triggers JNK pathway activation and JNK-dependent cell death. PMID: 28150056
  3. tissue-specific downregulation of the Drosophila homolog of human c-myc proto-oncogene (dMyc) suppresses tau-mediated morphological and functional deficits by reducing abnormal tau hyperphosphorylation and restoring the heterochromatin loss. PMID: 27000837
  4. dMyc has an essential role in preventing JNK-mediated retinal glial activation PMID: 28267791
  5. the key target of the Psi/MED network in controlling developmentally regulated tissue growth is the transcription factor MYC. PMID: 27207882
  6. Myc dosage plays crucial role in determining sex-specific size in Drosophila larvae and adult tissue. Double dose of Myc in females serves at least twice in development to promote sexual size dimorphism. PMID: 28064166
  7. BicC down regulates Myc in the Malpighian tubule. PMID: 28406902
  8. activation of the TOR-Myc axis in midgut stem and progenitor cells influences a variety of traits in Drosophila PMID: 27693629
  9. a functional link between Myc, a renowned oncogene, and the essential nucleotide biosynthetic enzyme CTPsyn. PMID: 26889675
  10. MYC and S6K cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A. PMID: 26215099
  11. The data demonstrate that dMYC repression and dMYC-dependent overgrowth in the Hfp hypomorph is further impaired in the C-terminal Hay/XPB mutant background. PMID: 26074141
  12. Myc acts as a master regulator of small nucleolar ribonucleoprotein biogenesis. PMID: 25888729
  13. In this review, we focus on studies of MYC in the fruitfly with particular emphasis on metabolism and cell competition, highlighting the contributions of this model system in the last decade to our understanding of MYC's complex biological nature PMID: 25010747
  14. Review discussing competitive interactions that are regulated by cell-to-cell differences in MYC activity and their role in tumor formation. PMID: 24692189
  15. Myc may act as a pro-aging factor, possibly through its ability to greatly increase genome instability PMID: 24040302
  16. a basal level of dMyc expression is required for Intestinal stem cell maintenance, proliferation and lineage differentiation during normal tissue homeostasis. PMID: 23896988
  17. These novel results give additional support for finding future approaches to specifically inhibit the growth of cancer cells addicted to oncogenic Myc. PMID: 23950728
  18. this study shows that puf genetically and physically interacts with dMyc and the ubiquitin ligase archipelago (ago) to modulate a dMyc-dependent cell growth phenotype, and that varying Puf levels in both the eye and wing phenocopies the effects of altered dMyc abundance. PMID: 24173801
  19. Drosophila Myc controls cell competition during larval wing development. (Review) PMID: 23696362
  20. dMyc expression in the fat body affects animal size. PMID: 23608455
  21. Myc is present at promoters and enhancers of Drosophila melanogaster genes during interphase. PMID: 23403565
  22. TSC1/2 and Myc coordinate the growth and division of Drosophila intestinal stem cells. PMID: 21555458
  23. The interdependent regulation of Yorkie and the proto-oncogene Myc is described. PMID: 21215937
  24. Data show that show that diminutive is an X-linked numerator, a regulator Sxl-Pe. PMID: 21220321
  25. viriato acts downstream of dMyc to ensure a coordinated nucleolar response to dMyc-induced growth and, thereby, normal organ development PMID: 21177347
  26. down-regulation of dHCF-associated histone acetyltransferase and histone methyltransferase complexes in vivo interferes with the Myc biological activities. PMID: 20937797
  27. The cell-autonomous upregulation of dMyc is required for the supercompetitive behavior of Yki-expressing cells and Hpo pathway mutant cells. PMID: 20885789
  28. The codependent regulatory relationship functionally coordinates the cellular activities of Yki and Myc and provides a mechanism of growth control that regulates organ size and has broad implications for cancer. PMID: 20951343
  29. regulation of dmyc requires interaction between the transcriptional repressor Hfp and the DNA helicase subunit of TFIIH, Haywire (Hay) PMID: 20667914
  30. In conclusion, the present work reveals an unexpected function of dMyc in the systemic control of growth in response to steroid hormone signaling. PMID: 20627082
  31. miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing PMID: 20400939
  32. experiments indicate that rather than directly influence differential growth in the wing disc, the pattern of dMyc expression augments growth directed by other regulators PMID: 19897747
  33. Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. PMID: 12208851
  34. Cell competition is executed via induction of the proapoptotic gene hid and that both competition and hid function are required for the wing to reach an appropriate size when dMyc is expressed. PMID: 15066286
  35. The heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells. PMID: 15066287
  36. Larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt. PMID: 15128666
  37. during animal development, the control of rRNA synthesis and ribosome biogenesis is an essential Myc function PMID: 15723055
  38. reptin and pontin have conserved their ability to bind to Myc during evolution PMID: 16087886
  39. c-Myc isoforms differentially regulate cell growth and apoptosis in a species-specific manner PMID: 16260605
  40. Study demonstrates that Lid is a JmjC-dependent trimethyl H3K4 demethylase in vivo and that this enzymatic activity is negatively regulated by Myc, which binds to Lid's JmjC domain. PMID: 17311883
  41. Myc-Groucho complex defines a mechanism of Myc function and may serve as the transcriptional unit that integrates EGF and Notch inputs to regulate early neuronal development. PMID: 17898168
  42. These results taken together indicate that dMyc is indeed required for dDREF gene expression. PMID: 17963749
  43. ability of cells to perceive and respond to local differences in Myc activity is a cooperative mechanism PMID: 18000039
  44. Studies examine nutritional control of gene expression and identify the transcription factor Myc as an important mediator of TOR-dependent regulation of ribosome biogenesis. PMID: 18177722
  45. dMnt repression is normally overridden by dMyc activation during larval development. PMID: 18241851
  46. Study shows that dMyc induced apoptosis is accompanied by the induction of Drosophila p53 mRNA, but that dp53 activity is not essential for dMyc's ability to induce apoptosis. PMID: 18257071
  47. We find that many biological activities of Myc do not, or only partly, require the association with Max-- PMID: 19165923
  48. Insulin receptor/Foxo signaling controls cell cycle progression by modulating dmyc expression and dMyc transcriptional activity PMID: 19211682
  49. Although MB2 and MB3 are highly conserved in evolution, loss of either domain has comparatively mild consequences on Myc activity in vivo. PMID: 19248823
  50. Wingless and Myc are induced by tissue damage and are important for regenerative growth. PMID: 19531351

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Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After g
Database Links

KEGG: dme:Dmel_CG10798

STRING: 7227.FBpp0303995

UniGene: Dm.4239

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