Prostate Cancer

Prostate cancer is one of the most common malignant tumors of the male reproductive system, and is especially common in the group of men aged 65 and older. Prostate cancer usually grows slowly and many patients may not be affected by prostate cancer during their lifetime. However, for advanced or metastatic prostate cancer, treatment options are limited and the prognosis is poor.

Treatment options for prostate cancer include surgery, radiation therapy, chemotherapy, and hormone therapy. In recent years, significant progress has been made in the field of prostate cancer treatment, especially in targeted therapy and immunotherapy. For example, the development and application of androgen receptor inhibitors such as enzalutamide have provided new treatment options for patients with advanced prostate cancer. In addition, immune checkpoint blockade therapies targeting the programmed death receptor (PD-1) or programmed death ligand (PD-L1) signaling pathways have shown potential in the treatment of prostate cancer.

Recent studies have also revealed that the secreted protein Gremlin1, a novel ligand for FGFR1, regulates tumor cell plasticity through the FGFR1/MAPK signaling pathway and promotes the development of denervation-resistant prostate cancer (CRPC). This provides new candidates and therapeutic strategies for targeted therapy of CRPC.

Prostate Cancer Drug Targets

Prostate Cancer Drug Target Related Products

● Target Proteins

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

CD276
CSB-MP733578HU

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC₅₀ of human CD276 protein is 1.961-2.243 ng/ml.

CD46
CSB-MP004939HU

Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC₅₀ of human CD46 protein is 0.8333-1.054 ng/ml.

NT5E
CSB-MP723415HU

Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC₅₀ is 1.102-1.707 ng/mL.

DLL3
CSB-MP882142HU

Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody（CSB-RA882142A1HU）, the EC⁵⁰ is 1.102-1.707 ng/mL.

Product Name	Code	Target	Source	Tag Info
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Membrane cofactor protein (CD46), partial (Active)	CSB-MP004939HU	CD46	Mammalian cell	C-terminal hFc-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	CSB-MP882142HU	DLL3	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Delta-like protein 3 (DLL3), partial (Active)	CSB-MP3536MOV	DLL3	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active)	CSB-MP007765HU	ERBB3	Mammalian cell	C-terminal hFc-tagged
Recombinant Human 5'-nucleotidase (NT5E), partial (Active)	CSB-AP005071HU	NT5E	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse 5'-nucleotidase (Nt5e), partial (Active)	CSB-AP005101MO	Nt5e	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human 5'-nucleotidase (NT5E) (Active)	CSB-MP723415HU	NT5E	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active)	CSB-MP619964HU1	PDCD1	Mammalian cell	C-terminal 6xHis-tagged

● Cell Lines

HEK293F/Human DLL3 Stable Cell Line

CSB-SC882142HU

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2µg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

● Recombinant antibodies

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

Product Name	Code	Target	Species Reactivity	Tested Applications
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CDH6 Recombinant Monoclonal Antibody	CSB-RA005055MA1HU	CDH6	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody	CSB-RA588766A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA2HU	ERBB2	Human	ELISA, IHC
FGFR3 Recombinant Monoclonal Antibody	CSB-RA555849A0HU	FGFR3	Human	ELISA, IF
FGFR3 Recombinant Monoclonal Antibody	CSB-RA966627A0HU	FGFR3	Human	ELISA, WB
IFNAR1 Recombinant Monoclonal Antibody	CSB-RA011046A0HU	IFNAR1	Human	ELISA

● ELISA Kits

Product Name	Code	Target	Detection Range	Sensitivity
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA kit	CSB-E14285h	CD276	3.12 ng/mL-200 ng/mL	0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA kit	CSB-E09296h	CD28	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA kit	CSB-E09884h	CD38	0.9 ng/mL-60 ng/mL	0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit	CSB-EL004929MO	CD38	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human membrane cofactor protein,MCP ELISA kit	CSB-E09216h	CD46	3.12 ng/mL-200 ng/mL	0.78 ng/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human Delta-like protein 3(DLL3) ELISA kit	CSB-EL006948HU	DLL3	18.75 pg/mL-1200 pg/mL	4.68 pg/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA kit	CSB-E11161h	ERBB2	0.156 ng/mL-10 ng/mL	0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit	CSB-EL007765HU	ERBB3	125 pg/mL-8000 pg/mL	31.25 pg/mL
Human Glutamate carboxypeptidase 2(FOLH1) ELISA kit	CSB-EL008782HU	FOLH1	4.7 ng/mL-300 ng/mL	1.2 ng/mL
Human insulin-like growth factors 1 receptor,IGF-1R ELISA kit	CSB-E13766h	IGF1R	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Rat Insulin-like Growth Factors 1 Receptor,IGF-1R ELISA kit	CSB-E13873r	IGF1R	3.12 pg/mL-200 pg/mL	0.8 pg/mL
Bovine Interleukin 12,IL-12 ELISA kit	CSB-E14010B	IL12A	6.25 pg/mL-400 pg/mL	1.56 pg/mL
Human Kallikrein 2(hK 2) ELISA kit	CSB-E13094h	KLK2	62.5 pg/mL-4000 pg/mL	15.6 pg/mL
Mouse Programmed Death 1(PD-1)ELISA kit	CSB-E13586m	PDCD1	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human Programmed Death 1(PD-1)ELISA kit	CSB-E13643h	PDCD1	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Vascular Endothelial cell Growth Factor,VEGF ELISA kit	CSB-E04756m	VEGFA	3.906 pg/mL-250 pg/mL	0.857 pg/mL
Human Vascular Endothelial cell Growth Factor(VEGF) ELISA kit	CSB-E11718h	VEGFA	31.25 pg/mL-2000 pg/mL	25.297 pg/mL
Rat Vascular Endothelial cell Growth Factor,VEGF ELISA kit	CSB-E04757r	VEGFA	3.9 pg/mL-250 pg/mL	0.97 pg/mL
Dog Vascular Endothelial cell Growth Factor,VEGF ELISA kit	CSB-E11744c	VEGFA	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Pig Vascular Endothelial cell Growth Factor,VEGF ELISA kit	CSB-E12053p	VEGFA	4.69 pg/mL-300 pg/mL	1.17 pg/mL
Bovine Vascular endothelial growth factor A(VEGFA) ELISA kit	CSB-EL025833BO	VEGFA	47 pg/mL-3000 pg/mL	11.75 pg/mL