World Pancreatic Cancer Day
World Pancreatic Cancer Day is observed on the third Thursday of November each year, aiming to raise public awareness and attention to pancreatic cancer. Pancreatic cancer is a malignant tumor that occurs in the cells of the pancreas, which is located in the back of the stomach and is responsible for secreting digestive enzymes and hormones that regulate blood glucose levels.
The etiology of pancreatic cancer is not fully understood, but several risk factors are known, including smoking, obesity, diabetes, chronic pancreatitis, and family history. Pancreatic cancer usually has a poor prognosis, with a 5-year survival rate of less than 10%. Early symptoms are nonspecific and often go unnoticed until the cancer is in its advanced stages, earning it the nickname "king of cancers." Globally, pancreatic cancer ranks 13th in incidence among all malignant tumors and 8th in mortality related to cancer.
There are two main types of pancreatic cancer: exocrine pancreatic cancer, which accounts for about 95% of all cases, and endocrine or islet cell tumors (also known as insulinocytomas), the latter of which is rarer. Early symptoms of pancreatic cancer are atypical and may include upper abdominal discomfort or vague pain, weight loss, and fatigue, which can easily be mistaken for other digestive diseases. Therefore, enhancing early diagnosis and treatment of pancreatic cancer is of great significance in improving the prognosis of pancreatic cancer patients.
The treatments for pancreatic cancer mainly include surgical resection, chemotherapy, radiotherapy, immunotherapy and targeted therapy. Immunotherapy has emerged as a new focus in the treatment of pancreatic cancer in recent years. Currently, several antibody drugs targeting different antigens, such as IGF-1R, EGFR, HER2, VEGF, CTLA-4, and PD-1, are in clinical research stages [1].
In order to better assist you in pancreatic cancer related mechanism research and drug development, CUSABIO has compiled a list of popular targets and corresponding products for pancreatic cancer research for your reference.
Pancreatic Cancer Drug Targets
Pancreatic Cancer Drug Target Related Products
● Target Proteins
Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.
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Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml
Measured by its binding ability in a functional ELISA. Immobilized MUC16 at 10 μg/ml can bind MSLN (CSB-MP015044HUc9), the EC50 is 460.7-662.2 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized Human TROP2 at 2 μgg/mL can bind Anti-TROP2 recombinant antibody (CSB-RA023072MA1HU), the EC50 is 0.9108-1.640 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized TNFRSF9 at 2 μg/ml can bind TNFSF9 (CSB-MP023997HU1), the EC50 is 1.011-2.429 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B at 2 μg/ml can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU), the EC50 is 24.13-46.04 ng/mL.
| Product Name |
Code |
Target |
Source |
Tag Info |
| Recombinant Human Tyrosine-protein kinase receptor UFO (AXL), partial (Active) |
CSB-MP326981HUd7 |
AXL |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) |
CSB-MP004847HU |
CCR8 |
Mammalian cell |
C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) |
| Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) |
CSB-MP878942HU1 |
CD274 |
Mammalian cell |
C-terminal hFc-tagged |
| Recombinant Human CD276 antigen (CD276), partial (Active) |
CSB-MP733578HU |
CD276 |
Mammalian cell |
C-terminal hFc-Myc-tagged |
| Recombinant Macaca fascicularis CD276 molecule(CD276), partial (Active) |
CSB-MP5140MOV |
CD276 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) |
CSB-AP005181HU |
CD40 |
Mammalian cell |
C-terminal Fc-tagged |
| Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) |
CSB-MP004936HU1 |
CD40 |
Mammalian cell |
C-terminal hFc-tagged |
| Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) |
CSB-AP005201HU |
CD47 |
Mammalian cell |
C-terminal 6xHis-tagged |
| Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) |
CSB-MP004940HU |
CD47 |
Mammalian cell |
C-terminal hFc-tagged |
| Recombinant Mouse CUB domain-containing protein 1 (Cdcp1), partial (Active) |
CSB-MP719456MO |
Cdcp1 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Human CUB domain-containing protein 1 (CDCP1), partial (Active) |
CSB-MP884474HU |
CDCP1 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Macaca fascicularis CUB domain containing protein 1 (CDCP1), partial (Active) |
CSB-MP4569MOV |
CDCP1 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Human Cadherin-17 (CDH17), partial (Active) |
CSB-MP613267HU |
CDH17 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) |
CSB-MP4664MOV |
CDH17 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1), partial, Biotinylated (Active) |
CSB-MP005157HU-B |
CEACAM1 |
Mammalian cell |
C-terminal 10xHis-Avi-tagged |
| Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) |
CSB-MP005165HU |
CEACAM5 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Macaca mulatta Carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5), partial (Active) |
CSB-MP5152MOW |
CEACAM5 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active) |
CSB-MP005166HU |
CEACAM6 |
Mammalian cell |
C-terminal 10xHis-tagged |
| Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active) |
CSB-MP4304MOV |
CLDN18 |
Mammalian cell |
N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions) |
| Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active) |
CSB-MP005498MO(F3) |
Cldn18 |
Mammalian cell |
N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions) |
● Cell Lines
● Antibodies
Tested Applications：
ELISA, WB, IF, FC
Tested Applications：
ELISA, WB, IHC, IF, FC
Tested Applications：
ELISA, WB, IHC, IF, FC
Tested Applications：
ELISA, WB, IF, FC
| Product Name |
Code |
Target |
Species Reactivity |
Tested Applications |
| Phospho-AKT1 (T450) Recombinant Monoclonal Antibody |
CSB-RA001553A450phHU |
AKT1 |
Human |
ELISA, WB |
| Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody |
CSB-RA001553A473phHU |
AKT1 |
Human |
ELISA, WB, IHC, IF, IP |
| AKT1 Recombinant Monoclonal Antibody |
CSB-RA917625A0HU |
AKT1 |
Human, Mouse, Rat |
ELISA, WB, IHC, IF |
| ANXA1 Recombinant Monoclonal Antibody |
CSB-RA001836MA1HU |
ANXA1 |
Human |
ELISA, IHC, FC |
| BAG3 Recombinant Monoclonal Antibody |
CSB-RA002531A0HU |
BAG3 |
Human |
ELISA, WB, IHC |
| CCR8 Recombinant Monoclonal Antibody |
CSB-RA004847A1HU |
CCR8 |
Human |
FC |
| CCR8 Recombinant Monoclonal Antibody |
CSB-RA004847MA3HU |
CCR8 |
Human |
FC |
| CCR8 Recombinant Monoclonal Antibody |
CSB-RA004847MA2HU |
CCR8 |
Human |
FC |
| CCR8 Recombinant Monoclonal Antibody |
CSB-RA004847MA4HU |
CCR8 |
Human |
FC |
| CD274 Recombinant Monoclonal Antibody |
CSB-RA977797A0HU |
CD274 |
Human |
ELISA, WB, IHC |
| CD274 Recombinant Monoclonal Antibody |
CSB-RA878942MA1HU |
CD274 |
Human |
ELISA, IHC, FC |
| CD40 Recombinant Monoclonal Antibody |
CSB-RA004936MA1HU |
CD40 |
Human |
ELISA, IF, FC |
| CD47 Recombinant Monoclonal Antibody |
CSB-RA802124A0HU |
CD47 |
Human |
ELISA, WB, IHC, IF |
| CD8A Recombinant Monoclonal Antibody |
CSB-RA934881A0HU |
CD8A |
Human |
ELISA, WB, IHC, IP |
| CDCP1 Recombinant Monoclonal Antibody |
CSB-RA884474MA1HU |
CDCP1 |
Human, Mouse, Macaca fascicularis |
ELISA |
| CDH17 Recombinant Monoclonal Antibody |
CSB-RA613267MA1HU |
CDH17 |
Human |
ELISA，FC |
| CEACAM1 Recombinant Monoclonal Antibody |
CSB-RA147192A0HU |
CEACAM1 |
Human |
ELISA, IHC |
| CEACAM5 Recombinant Monoclonal Antibody |
CSB-RA005165MA3HU |
CEACAM5 |
Human |
ELISA, IF, FC |
| CEACAM5 Recombinant Monoclonal Antibody |
CSB-RA005165MA1HU |
CEACAM5 |
Human |
ELISA |
| CLDN18 Recombinant Monoclonal Antibody |
CSB-RA005498A2HU |
CLDN18 |
Human |
ELISA, FC |
● ELISA Kits
| Product Name |
Sample Types |
Detect Range |
Code |
| Human RAC-alpha serine/threonine-protein kinase(AKT1) ELISA kit |
serum, plasma, cell lysates |
0.312 ng/mL-20 ng/mL |
CSB-EL001553HU |
| Mouse Annexin A1(ANXA1) ELISA kit |
serum, plasma, tissue homogenates |
1.37ng/ml - 1000ng/ml |
CSB-EL001836MO |
| Human Annexin Ⅰ(ANX-Ⅰ) ELISA Kit |
serum, plasma, tissue homogenates |
0.312 ng/mL-20 ng/mL |
CSB-E12155h |
| Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit |
serum, plasma, tissue homogenates |
31.25 pg/mL-2000 pg/mL |
CSB-EL002476HU |
| Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit |
serum, plasma, tissue homogenates. |
31.25 pg/ml-2000 pg/ml |
CSB-EL002476MO |
| Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit |
serum, plasma, tissue homogenates, cell lysates |
15.6 pg/mL-1000 pg/mL |
CSB-E13644h |
| Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit |
serum, plasma, tissue homogenates |
31.25 pg/mL-2000 pg/mL |
CSB-EL004911MO |
| Human Soluble CD276,sCD276/sB7-H3 ELISA Kit |
serum, plasma, urine, cell culture supernates |
3.12 ng/mL-200 ng/mL |
CSB-E14285h |
| Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit |
|
Request Information |
CSB-EL004936MO |
| Human Leukocyte surface antigen CD47(CD47) ELISA kit |
serum, plasma, urine, tissue homogenates |
3.12 pg/mL-200 pg/mL |
CSB-EL004940HU |
| Mouse Leukocyte surface antigen CD47(CD47) ELISA kit |
serum, plasma,tissue homogenates |
15.6 pg/mL-1000 pg/mL |
CSB-EL004940MO |
| Human Cluster of differentiation 8,CD8 ELISA Kit |
serum, plasma, cell culture supernates, tissue homogenates |
62.5 U/mL-4000 U/mL |
CSB-E12707h |
| Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) ELISA kit |
serum, plasma, tissue homogenates |
0.78 ng/mL-50 ng/mL |
CSB-EL005157HU |
| Human carcinoembryonic antigen,CEA ELISA Kit |
serum, plasma, tissue homogenates |
5 ng/mL-120 ng/mL |
CSB-E04767h |
| Mouse carcinoembryonic antign,CEA ELISA Kit |
serum, plasma, tissue homogenates |
62.5 pg/mL-4000 pg/mL |
CSB-E13925m |
| Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit |
serum, plasma, tissue homogenates |
0.83 ng/mL-20 ng/mL |
CSB-EL005166HU |
| Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit |
serum, plasma, tissue homogenates |
0.156 ng/mL-10 ng/mL |
CSB-E10012h |
| Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit |
serum, plasma, tissue homogenates |
0.312 ng/mL-20 ng/mL |
CSB-EL006044RA |
| Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit |
serum, plasma, tissue homogenates |
125 pg/mL-8000 pg/mL |
CSB-E09171h |
| Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit |
serum, plasma, tissue homogenates |
0.312 ng/mL-20 ng/mL |
CSB-E13637m |
Drug Development Solutions
References
[1] Therapeutic Application of Monoclonal Antibodies in Pancreatic Cancer: Advances, Challenges and Future Opportunities. Cancers (Basel), 2021.
