Esophageal Cancer

Esophageal cancer is a malignant tumor originating from the epithelial cells of the esophagus, and its incidence and mortality rates are high worldwide. The two main types of esophageal cancer are squamous cell carcinoma and adenocarcinoma, with squamous cell carcinoma being more common in Asia and adenocarcinoma being more prevalent in Western countries. Causes of esophageal cancer may include smoking, alcohol consumption, long-term gastroesophageal reflux disease, Barrett's esophagus, and certain genetic factors.

Treatment of esophageal cancer depends on the stage and location of the cancer and the overall health of the patient. Early stage esophageal cancer may be treated with endoscopic therapy (e.g., endoscopic mucosal resection or endoscopic mucosal dissection). For more advanced esophageal cancer, common treatments include surgical resection, chemotherapy, radiation therapy, or a combination of these methods.

In recent years, significant progress has been made in drug development for esophageal cancer. Immunotherapy has become the new standard of care in the treatment of advanced esophageal cancer, especially for patients who have failed first-line chemotherapy. Immune checkpoint inhibitors, such as Pembrolizumab, Nivolumab, and Camrelizumab, have demonstrated potential efficacy in clinical trials for patients with esophageal cancer. In addition, the use of Trastuzumab for HER2-positive adenocarcinoma of the esophagogastric junction has also shown some efficacy.

In terms of targeted therapy, drugs targeting specific molecular targets for tumor growth and angiogenesis are also being developed. For example, small molecule tyrosine kinase inhibitors targeting VEGFR, EGFR and HER2, such as Afatinib and Regorafenib, have shown some efficacy in the treatment of esophageal cancer.

Esophageal Cancer Drug Targets

Esophageal Cancer Drug Target Related Products

● Target Proteins

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CLDN18.2
CSB-MP005498HU(A5)

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC₅₀ is 5.225-9.256 ng/ml.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

TIGIT
CSB-MP675446HU

FACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155

ERBB3
CSB-MP007765HU

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC₅₀ is 12.32-15.74 ng/ml.

MET
CSB-MP013714HU

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC₅₀ is 2.379-3.094 ng/ml.

Product Name	Code	Target	Source	Tag Info
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active)	CSB-MP4304MOV	CLDN18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active)	CSB-MP005498MO(F3)	Cldn18	Mammalian cell	N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active)	CSB-MP007765HU	ERBB3	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active)	CSB-MP010053HU	GUCY2C	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active)	CSB-MP010053HUd9	GUCY2C	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005281HU	HAVCR2	Mammalian cell	C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005291HU	HAVCR2	Mammalian cell	C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active)	CSB-AP005341MO	Havcr2	Mammalian cell	C-terminal Fc-tagged

● Recombinant antibodies

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

Claudin-18.2 Recombinant Monoclonal Antibody
CSB-RA005498A1HU

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected.

GUCY2C Recombinant Monoclonal Antibody
CSB-RA010053A3HU

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2µg/1*10⁶ cells),

Product Name	Code	Target	Species Reactivity	Tested Applications
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CLDN18 Recombinant Monoclonal Antibody	CSB-RA005498A2HU	CLDN18	Human	ELISA, FC
Claudin-18.2 Recombinant Monoclonal Antibody	CSB-RA005498A1HU	CLDN18	Human	ELISA, FC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody	CSB-RA588766A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA2HU	ERBB2	Human	ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody	CSB-RA937008A0HU	ERBB3	Human	ELISA, IF
GUCY2C Recombinant Monoclonal Antibody	CSB-RA010053A3HU	GUCY2C	Human	ELISA, FC
GUCY2C Recombinant Monoclonal Antibody	CSB-RA010053A2HU	GUCY2C	Human	ELISA, FC
IL2RA Recombinant Monoclonal Antibody	CSB-RA011649MA1HU	IL2RA	Human	ELISA, IF
MET Recombinant Monoclonal Antibody	CSB-RA983271A0HU	MET	Human	ELISA, WB, IHC, IF, FC
MET Recombinant Monoclonal Antibody	CSB-RA634199A0HU	MET	Human	ELISA, IHC
MET Recombinant Monoclonal Antibody	CSB-RA013714MA1HU	MET	Human	ELISA, IF, FC
MUC17 Recombinant Monoclonal Antibody	CSB-RA727848MA1HU	MUC17	Human	ELISA
NECTIN4 Recombinant Monoclonal Antibody	CSB-RA822274A0HU	NECTIN4	Human	ELISA
PDCD1 Recombinant Monoclonal Antibody	CSB-RA240597A0HU	PDCD1	Human	ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody	CSB-RA792129A0HU	TOP1	Human	ELISA, WB, IHC, FC, IP

● ELISA Kits

Product Name	Code	Target	Detection Range	Sensitivity
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit	CSB-E11161h	ERBB2	0.156 ng/mL-10 ng/mL	0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit	CSB-EL007765HU	ERBB3	125 pg/mL-8000 pg/mL	31.25 pg/mL
Human Hepatitis A virus cellular receptor 2(HAVCR2) ELISA kit	CSB-EL010145HU	HAVCR2	47 pg/mL-3000 pg/mL	11.75 pg/mL
Bovine Interleukin 12,IL-12 ELISA Kit	CSB-E14010B	IL12A	6.25 pg/mL-400 pg/mL	1.56 pg/mL
Human Interleukin 15,IL-15 ELISA KIT	CSB-E04603h	IL15	3.12 pg/ml - 200 pg/ml	0.78 pg/ml
Mouse Interleukin 15,IL-15 ELISA Kit	CSB-E04604m	IL15	0.3125 - 20ng/ml	0.078 ng/ml
Rat Interleukin 15,IL-15 ELISA KIT	CSB-E07453r	IL15	1.56 pg/mL-100 pg/mL	0.39 pg/mL
Pig Interleukin 15(IL-15) ELISA Kit	CSB-E14320p	IL15	0.78 pg/mL-50 pg/mL	0.195 pg/mL
Monkey Interleukin 15,IL-15 ELISA Kit	CSB-E14392Mk	IL15	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human soluble interleukin-2 receptor,IL-2sRα ELISA kit	CSB-E04629h	IL2RA	78 pg/mL-5000 pg/mL	19.5 pg/mL
Mouse soluble interleukin-2 receptor,sIL-2Rα ELISA kit	CSB-E07440m	IL2RA	15.6 pg/ml - 1000 pg/ml	3.9 pg/ml