Cardiovascular Diseases

Cardiovascular diseases are a group of diseases that affect the heart and vascular system, including heart disease and peripheral vascular disease. Heart disease mainly involves abnormalities in the structure of the heart, such as coronary artery disease, which is caused by insufficient blood supply to the coronary arteries leading to myocardial ischemia or hypoxia. Peripheral vascular disease, on the other hand, affects blood vessels other than the heart, such as abnormal blood supply vessels in the upper and lower extremities and trunk.

Targeted therapies against specific receptors and signaling pathways are an important direction in drug development for cardiovascular diseases, e.g:

G protein-coupled receptors (GPCRs): GPCRs are a large class of cell-surface receptors that regulate a variety of physiological processes in the cardiovascular system, including the control of blood pressure and heart rate. Apelin receptor (APLNR) is a member of the GPCR family, which is potentially therapeutic in cardiovascular disease. By designing specific agonists, it is possible to activate the G protein signaling pathway and reduce deleterious myocardial hypertrophy, providing a new strategy for the treatment of heart failure.
Thromboxane A2 receptor (TP): TP is a key regulator of platelet aggregation and vascular smooth muscle cell contraction, and is a potential target for the treatment of atherosclerosis and hypertension. By studying the binding mode of TP to its ligands, specific TP inhibitors can be designed to reduce cardiovascular disease.
Ion channels: Ion channels in cardiac and vascular smooth muscle cells play a central role in regulating cardiac rhythm and vascular tone. Drugs that target specific ion channels, such as calcium channel blockers, have been widely used to treat hypertension and angina.
Enzyme inhibitors: For example, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) lower blood pressure and reduce the risk of cardiovascular disease by blocking the renin-angiotensin system.
Fatty acid and lipid metabolism modifiers: Statins lower cholesterol levels and reduce the risk of cardiovascular disease by inhibiting HMG-CoA reductase.
Anticoagulant drugs: Prevent thrombosis by reducing blood clotting and are used to treat or prevent stroke and myocardial infarction.

Cardiovascular Diseases Drug Targets

Cardiovascular Diseases Drug Target Related Products

● Target Proteins

TNFRSF17
CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

GHR
CSB-MP009411HU

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

GPRC5D
CSB-MP882153HU

Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC₅₀ is 8.847-10.38 ng/mL.

IL6
CSB-YP011664HU

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU)，the EC₅₀ is 35.80-41.82 ng/mL.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

ANGPT2
CSB-MP001707HU(A4)

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC₅₀ is 0.6666-0.8876 ng/mL

Product Name	Code	Target	Source	Tag Info
Recombinant Human Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707HU(A4)	ANGPT2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707DO	ANGPT2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Growth hormone receptor (GHR), partial (Active)	CSB-MP009411HU	GHR	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active)	CSB-MP009411HUj1-B	GHR	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active)	CSB-MP009514HUb1	GLP1R	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human G-protein coupled receptor family C group 5 member D (GPRC5D)-VLPs (Active)	CSB-MP882153HU	GPRC5D	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Hepatocyte growth factor (HGF) (Active)	CSB-AP003681HU	HGF	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Rhesus Macaque Interleukin-1 beta protein (IL1B) (Active)	CSB-AP003081MOW	IL1B	E.Coli	Tag-Free
Recombinant Mouse Interleukin-1 beta protein (Il1b) (Active)	CSB-AP003261MO	Il1b	E.Coli	Tag-Free
Recombinant Horse Interleukin-1 beta protein (IL1B) (Active)	CSB-AP003481HO	IL1B	E.Coli	Tag-Free

● Recombinant antibodies

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

Product Name	Code	Target	Species Reactivity	Tested Applications
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA191985A0HU	ANGPT2	Human	ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA001707MA01HU	ANGPT2	Human	ELISA
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA

● ELISA Kits

Product Name	Code	Target	Detection Range	Sensitivity
Human Angiopoietin 2,ANG-2 ELISA Kit	CSB-E04500h	ANGPT2	39 pg/mL-2500 pg/mL	9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07304r	ANGPT2	Request Information	Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07305m	ANGPT2	0.156 pg/mL-10 pg/mL	0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit	CSB-E08460p	ANGPT2	0.94 ng/mL-60 ng/mL	0.235 ng/mL
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit	CSB-E11724h	ANGPTL3	78 pg/mL-5000 pg/mL	19.5 pg/mL
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit	CSB-EL001711MO	ANGPTL3	31.25 pg/mL-2000 pg/mL	10.24 pg/mL
Human Complement C1s subcomponent(C1S) ELISA kit	CSB-EL003657HU	C1S	25 ng/mL-1600 ng/mL	6.25 ng/mL
Mouse Complement 5,C5 ELISA Kit	CSB-E13802m	C5	0.25 ng/mL-16 ng/mL	0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit	CSB-E14363r	C5	9.38 ng/mL-600 ng/mL	2.34 ng/mL
Monkey complement C5 (C5) ELISA kit	CSB-EL003995MK	C5	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit	CSB-E09884h	CD38	0.9 ng/mL-60 ng/mL	0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit	CSB-EL004929MO	CD38	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human Erythropoietin receptor,EPOR ELISA Kit	CSB-E04537h	EPOR	0.156 ng/ml - 10 ng/ml	0.039 ng/ml