Infectious Diseases

Infectious diseases are diseases caused by different pathogens such as bacteria, viruses, fungi and parasites, and are capable of affecting various systems and organs of the body. These diseases can manifest as minor skin infections or serious systemic infections such as sepsis.

Common infectious diseases include bacterial pneumonia, urinary tract infections, and tuberculosis; viral infections such as influenza, AIDS, dengue fever, and COVID-19; fungal infections such as candidiasis and ringworm; and parasitic infections such as malaria and toxoplasmosis.

Treatment of infectious diseases usually requires the use of appropriate antibiotics, antivirals, antifungals, or antiparasitic agents, and vaccination is an effective means of preventing certain infectious diseases. In the face of the challenge of drug-resistant microorganisms, the development of new drugs and the improvement of existing drugs are essential for the treatment and control of infectious diseases.

Progress in drug development is described below:

Antimicrobial drugs: Research has focused on the development of novel antibiotics to combat the problem of drug resistance, exploring new molecular entities and mechanisms of action, including novel variants of β-lactams, macrolides, quinolones and carbapenem antibiotics.
Antivirals: R&D advances include targeting viral replicative enzymes, viral proteases, inhibition of viral entry into host cells, and blockade of viral release, e.g., oseltamivir for influenza and reverse transcriptase and protease inhibitors for HIV.
Antifungal drugs: R&D focuses on addressing drug resistance and developing new drugs to interfere with fungal cell wall synthesis, affect fungal membrane integrity and inhibit fungal DNA replication, e.g. echinocandins and pyrimidine analogs.
Antiparasitic drugs: Therapeutic research is devoted to interfering with parasite metabolic pathways, cellular structure, and altering host-parasite interactions.
Immunomodulators and biologics: Aimed at enhancing host immune responses or reducing autoimmune responses and inflammation, including interferons, tumor necrosis factor (TNF) inhibitors, and other biologics.
Vaccines: Vaccine development is key to preventing infectious diseases and includes novel vaccine designs, such as mRNA and viral vector vaccines against COVID-19, as well as improvements to existing vaccines.

Infectious Diseases Drug Targets

Infectious Diseases Drug Target Related Products

● Target Proteins

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

TNFRSF17
CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

TNFRSF8
CSB-MP023983HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC₅₀ is 14.96-20.25 ng/ml

IL2RA
CSB-MP011649HU3

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

Product Name	Code	Target	Source	Tag Info
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-AP005671HU	ACE2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial, Biotinylated (Active)	CSB-MP866317HU-B	ACE2	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-MP866317HU	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Macaca fascicularis Angiotensin-converting enzyme (ACE2), partial (Active)	CSB-MP3414MOV	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-MP684964PAL	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Basigin (BSG), partial (Active)	CSB-MP002831HU1	BSG	Mammalian cell	C-terminal hFc-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	CSB-MP004925HU	CD33	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	CSB-MP004953HU	CD7	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	CSB-AP005161HU	CD86	Mammalian cell	C-terminal 6xHis-tagged

● Cell Lines

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● Recombinant antibodies

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

Product Name	Code	Target	Species Reactivity	Tested Applications
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP
CD86 Recombinant Monoclonal Antibody	CSB-RA004965A0HU	CD86	Human	ELISA, WB
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
CXCL10 Recombinant Monoclonal Antibody	CSB-RA903061A0HU	CXCL10	Human	ELISA, IHC
CXCR4 Recombinant Monoclonal Antibody	CSB-RA569311A0HU	CXCR4	Human	ELISA, IF

● ELISA Kits

Product Name	Code	Target	Detection Range	Sensitivity
Rat Angiotensin converting enzyme 2, ACE2 ELISA Kit	CSB-E14308r	ACE2	0.02 ng/ml - 20 ng/ml	0.02 ng/ml
Human Angiotensin converting enzyme 2, ACE2 ELISA Kit	CSB-E04489h	ACE2	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Mouse Angiotensin converting enzyme 2(ACE2)ELISA Kit	CSB-E17204m	ACE2	6.25 pg/mL-400 pg/mL	1.56 pg/mL
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Human Cluster of differentiation 147,CD147 Elisa Kit	CSB-E12994h	BSG	12.5 pg/mL-800 pg/mL	3.12 pg/mL
Human soluble cluster of differentiation 14,sCD14 ELISA Kit	CSB-E13199h	CD14	0.234 ng/mL-15 ng/mL	0.229 ng/mL
Rat soluble cluster of differentiation 14,sCD14 ELISA Kit	CSB-E11178r	CD14	28 ng/mL-1800 ng/mL	7 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit	CSB-E09296h	CD28	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit	CSB-EL004925HU	CD33	125 pg/mL-8000 pg/mL	31.25 pg/mL