Lymphoma

Lymphoma is a group of malignant tumors originating in the lymph nodes and other lymphoid tissues. Based on their pathologic characteristics, lymphomas can be divided into two main groups: Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). HD is a rarer type, whereas NHL include a variety of subtypes, such as follicular and diffuse large B-cell lymphoma.

Lymphoma has a variety of causes and risk factors, including genetic factors, environmental factors, lifestyle, diet, and certain specific viral infections. For example, Epstein Barr virus and human T-lymphotropic virus-1 can directly infect lymphocytes and disrupt their normal function, thus increasing the risk of lymphoma. In addition, HIV infection significantly increases the risk of lymphoma.

There are various ways to treat lymphoma, including chemotherapy, radiotherapy, immunotherapy, targeted therapy, and hematopoietic stem cell transplantation. In recent years, with advances in medical research, the treatment of lymphoma has improved significantly.

The field of immunotherapy has undergone revolutionary changes since rituximab was the first successful immunotherapy for B-cell non-Hodgkin's lymphoma. The most exciting immunotherapies currently available include chimeric antigen receptor T cells (CAR-T), bispecific antibodies, immune checkpoint inhibitors and vaccines. In particular, monoclonal antibodies targeting PD-1/PD-L1 have shown remarkable therapeutic efficacy in patients with primary or relapsed refractory lymphoma.

Autologous hematopoietic stem cell transplantation is also one of the effective options for the treatment of lymphoma. Its pre-transplantation treatment has evolved from initially using high-dose radiotherapy alone as the pretreatment regimen to combining with rituximab (targeting CD20) or even combining with isotope-labeled monoclonal antibodies as the pretreatment regimen; rituximab has also evolved from being used only as a purifying drug before pretreatment to the long-term sequential use of rituximab before and after transplantation.

The treatment of lymphoma is developing in the direction of more personalization and precision. CUSABIO provides lymphoma drug development target proteins, stable cell lines, recombinant antibodies, ELISA kits and other products to help basic research and drug development.

Lymphoma Drug Targets

Lymphoma Drug Target Related Products

● Target Proteins

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

TNFRSF8
CSB-MP023983HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC₅₀ is 14.96-20.25 ng/ml

TNFSF9
CSB-MP023997HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9 (CSB-MP023984HU1), the EC₅₀ is 2.671-3.702 ng/mL

IL2RA
CSB-MP011649HU3

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

Product Name	Code	Target	Source	Tag Info
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	CSB-MP004925HU	CD33	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	CSB-MP004953HU	CD7	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003581HU	CSF2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003601HU	CSF2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003651MO	Csf2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003661MO	Csf2	E.coli	Tag-Free
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged

● Cell Lines

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● Recombinant antibodies

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

FTL Recombinant Monoclonal Antibody
CSB-RA956089A0HU

Overlay Peak curve showing MCF-7 cells stained with CSB-RA956089A0HU (red line) at 1:50.

ICAM1 Recombinant Monoclonal Antibody
CSB-RA162789A0HU

Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50.

Product Name	Code	Target	Species Reactivity	Tested Applications
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC

● ELISA Kits

Product Name	Code	Target	Detection Range	Sensitivity
Human Natural killer cell receptor 2B4(CD244) ELISA kit	CSB-EL004903HU	CD244	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit	CSB-E09296h	CD28	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit	CSB-EL004925HU	CD33	125 pg/mL-8000 pg/mL	31.25 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit	CSB-E09884h	CD38	0.9 ng/mL-60 ng/mL	0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit	CSB-EL004929MO	CD38	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human cluster of differentiation 4,CD4 ELISA Kit	CSB-E08956h	CD4	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Rat cluster of differentiation 4,CD4 ELISA Kit	CSB-E12928r	CD4	0.78 U/mL-50 U/mL	0.195 U/mL
Chicken Cluster of Differentiation 4(CD4) ELISA Kit	CSB-E13114C	CD4	3.125 ng/mL-800 ng/mL	3.125 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940HU	CD47	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit	CSB-EL004940MO	CD47	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human CAMPATH-1 antigen(CD52) ELISA kit	CSB-EL004943HU	CD52	78 ng/mL-5000 ng/mL	19.5 ng/mL
Mouse cluster of differentiation 6(CD6) ELISA Kit	CSB-EL004949MO	CD6	Request Information	Request Information
Human CD70 antigen(CD70) ELISA kit	CSB-EL004954HU	CD70	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit	CSB-EL004954MO	CD70	Request Information	Request Information
Mouse T-lymphocyte activation antigen CD80(CD80) ELISA kit	CSB-EL004959MO	CD80	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human Soluble Cluster of Differentiation 80 (sCD80) ELISA Kit	CSB-E15768h	CD80	125 pg/mL-8000 pg/mL	31.25 pg/mL