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| Code | CSB-AP002161HU |
| Product Type | Tumor Necrosis Factor |
| Size |
US$112Purchase it in Cusabio online store (Shop online in the US. Customers outside the US, please order from local distributors.) |
| Uniprot No. | P01375 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered 20 mM PB, 10 mM Nacl, pH 7.0 ,lyophilized |
| Alias | Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a, , NTF |
| Species | Homo sapiens (Human) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x107 IU/mg in the presence of actinomycin D. |
| Purity | >98% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | M+VRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELRDNQLV VPSEGLYLIY SQVLFKGQGC PSTHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA EAKPWYEPIY LGGVFQLEKG DRLSAEINRP DYLDFAESGQ VYFGIIAL |
| Research Area | Cancer |
| Source | E.coli |
| Gene Names | TNF |
| Expression Region | 77-233aa |
| Tag Info | Tag-Free |
| Mol. Weight | 17.5 kDa |
| Protein Description | Partial |
| PubMed ID | 3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 14656967; 15489334; 8631363; 8597870; 10205166; 2009860; 1402651; 9034191; 10369255; 16829952; 16829951; 22517918; 23396208; 2922050; 1964681; 2551905; 9488135; 9442056; 12746914; 12 |
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| Function | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective |
| Involvement in disease | Psoriatic arthritis (PSORAS) |
| Subcellular Location | Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor, membrane form: Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form: Secreted, SUBCELLULAR LOCATION: C-domain 1: Secreted, SUBCELLULAR LOCATION: C-domain 2: Secreted |
| Protein Families | Tumor necrosis factor family |
| Database Links |
HGNC: 11892 OMIM: 191160 KEGG: hsa:7124 STRING: 9606.ENSP00000398698 UniGene: Hs.241570 |
| Pathway |
MAPK signaling pathway
mTOR signaling pathway TGF-beta signaling pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis Necroptosis Antigen processing and presentation Fc epsilon RI signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Toll-like receptor signaling pathway Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications Inflammatory Pain |
TNF Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA07427D0Rb | TNF Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA07427C0Rb | TNF Antibody, FITC conjugated | Human | ELISA |
| CSB-PA07427B0Rb | TNF Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023955KA01HU | TNF Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA147864 | TNF Antibody | Human,Mouse | ELISA,IHC,IF |
| CSB-PA004310 | TNF Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA004963 | TNF Antibody | Human | WB,ELISA |
| CSB-PA080266 | TNF Antibody | Human,Mouse,Rat | WB |
| CSB-PA080267 | TNF Antibody | Human,Mouse,Rat | WB,IHC |
| CSB-MA080271 | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-MA080272 | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA954619 | TNF Antibody | Human | ELISA,IHC |
TNF Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA07427A0Rb | TNF Antibody | Human | ELISA, WB, IHC, IF |
TNF Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP023955HU | Recombinant Human Tumor necrosis factor(TNF) | E.coli |
| CSB-AP004861HU | Recombinant Human Tumor necrosis factor(TNF),partial (Active) | E.coli |
| CSB-AP004871HU | Recombinant Human Tumor necrosis factor(TNF),partial (Active) | E.coli |
| CSB-AP004881HU | Recombinant Human Tumor necrosis factor(TNF),partial (Active) | E.coli |
| CSB-AP005891HU | Recombinant Human Tumor Necrosis Factor-alpha/TNFSF2(TNF),partial (Active) (GMP) | E.Coli |
| CSB-AP002151HU | Recombinant Human Tumor necrosis factor protein(TNF) (Active) | E.coli |
| CSB-AP002141HU | Recombinant Human Tumor necrosis factor protein(TNF),partial (Active) | E.coli |
| CSB-RP074274h | Recombinant Human Tumor necrosis factor(TNF),partial | E.coli |
| CSB-EP023955HUc7 | Recombinant Human Tumor necrosis factor(TNF),partial (Active) | E.coli |
| CSB-YP023955HU | Recombinant Human Tumor necrosis factor(TNF),partial (Active) | Yeast |
TNF ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04740h | Human Tumor necrosis factor α,TNF-α ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 1.95 pg/mL |
Recombinant Human ATP synthase subunit alpha, mitochondrial(ATP5F1A)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Protein delta homolog 1(DLK1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Mouse Complement C1q subcomponent subunit A(C1qa)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Deoxycytidylate deaminase(DCTD)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Tryptophan--tRNA ligase, cytoplasmic(WARS)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human C-X-C motif chemokine 10(CXCL10)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Rat Thyrotropin subunit beta(Tshb)
Express system: Yeast
Species: Rattus norvegicus (Rat)
