NP Antibody

Code CSB-PA323576ZA01ZAB
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Product Details

Full Product Name Rabbit anti-Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) NP Polyclonal antibody
Uniprot No. P18272
Target Names NP
Alternative Names NPNucleoprotein antibody; Ebola NP antibody; eNP antibody; Nucleocapsid protein antibody; Protein N antibody
Raised in Rabbit
Species Reactivity Zaire ebolavirus
Immunogen Recombinant Zaire ebolavirus NP protein
Immunogen Species Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1.
Gene References into Functions
  1. The authors found that the recombinant NP helix is associated with non-viral RNA, which is not protected from RNase digestion and that the morphology of the helix changes depending on the environmental salt concentration. PMID: 20164259
Subcellular Location Virion. Host cytoplasm.
Protein Families Filoviruses nucleoprotein family
Database Links

KEGG: vg:911830

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