Rat Epidermal growth factor,EGF ELISA Kit

Code CSB-E08029r
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name Epidermal growth factor,EGF
Alternative Names Egf ELISA Kit; Pro-epidermal growth factor ELISA Kit; EGF) [Cleaved into: Epidermal growth factor] ELISA Kit
Abbreviation EGF
Uniprot No. P07522
Species Rattus norvegicus (Rat)
Sample Types serum, plasma, tissue homogenates
Detection Range 3.12 pg/mL-200 pg/mL
Sensitivity 0.78 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Others
Assay Principle quantitative
Measurement Sandwich
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

(From Uniprot)
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Gene References into Functions
  1. The expression of EGF was elevated on the first day after tympanic membrane (TM)injury, not reaching statistical significance, and then returned to the level observed in the control TM. PMID: 25920966
  2. A decrease in EGF levels may contribute to the formation of visceral hypersensitivity through downregulation of SERT-mediated 5-HT uptake into enterocytes. PMID: 25309082
  3. The role of EGF on apoptosis, cell proliferation, oxidative stress and antioxidant system in intestinal injury induced by ischemia/reperfusion in rats. PMID: 23932386
  4. results indentify EGF signalling as a robust vasculogenic inductive pathway for ATMCs, leading to their transdifferentiation into functional VSMC-like cells. PMID: 24967966
  5. Epidermal growth factor and erythropoietin infusion accelerate functional recovery in combination with rehabilitation. PMID: 24763928
  6. these findings indicate that cortical EGF levels decrease with a high-salt diet in salt-sensitive rats, promoting ENaC-mediated Na(+) reabsorption in the collecting duct and the development of hypertension. PMID: 23599382
  7. Epidermal growth factor modulates voltage sensitivity of slow sodium channels. PMID: 23821047
  8. Changes in colonic permeability during low-sodium adaptation are mediated by the EGF secreted by myofibroblasts in response to raised aldosterone. PMID: 23467299
  9. findings indicate NGF is an important regulator for the synthesis and secretion of EGF and insulin from beta cells. NGF withdrawal causes apoptosis by decreasing EGF, NGF and insulin secretion from beta cells of hyperglycemic rats. PMID: 22926925
  10. nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation PMID: 22514047
  11. There were no differences in the Egf expression between the rat strains at rest and under emotional stress in both the cortical and medullary kidney zones. PMID: 22645946
  12. NGF, GDNF and EGF stimulation of DRG-neurons shows differential Erk1/2 activation responses and a corresponding differential behavioral phenotype; EGF did not induce mechanical hyperalgesia, but blocked PGE2-induced sensitization PMID: 21187008
  13. EGF plays multiple roles in rat tympanic membrane (TM) wound healing. PMID: 20967565
  14. EGF also activates focal adhesion kinase in the cytoplasm to rephosphorylate Grb7, releasing KOR mRNA for active translation. PMID: 20142421
  15. epidermal growth factor (EGF) can be converted from a non-neuritogenic into a neuritogenic factor through moderate activation of endogenous SRC by receptor-protein-tyrosine phosphatase alpha (a physiological SRC activator) PMID: 11867627
  16. stimulation of recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts PMID: 11889128
  17. isoproterenol treatment leads to a hyperstimulatory state of granular convoluted tubule cells, which then causes depletion of cellular stores of mature EGF, and most likely due to a shortened posttranslational transit, incomplete peptide processing PMID: 12047917
  18. lymph node stromal cell lines expressed mRNA transcripts for IGF-I and EGF as major mitogenic factors which may contribute actively to the process of cancer cell dissemination PMID: 12115579
  19. EGF is internalized into clathrin-coated vesicles by NLRR-3, resulting in Ras-MAPK signaling PMID: 12297494
  20. EGF plays a role in T3-induced cerebellar development in astrocytes PMID: 12356760
  21. EGF- and Src-mediated transactivation pathway for IGF-IR activation in hepatocytes, and indicate a role for the IGF-IR in hepatocyte intracellular signaling. PMID: 12447877
  22. both epidermal growth factor and thyrotropin releasing hormone stimulated prolactin gene transcription appear to require protein kinase C delta, whereas protein kinase C eta may also be able to transmit the epidermal growth factor response PMID: 12456804
  23. Mucosal permeability regulates receptor binding of luminal EGF in the adult rat small intestine. PMID: 12579338
  24. IGF1 and EGF synergistically suppress apoptosis in salivary acinar cells PMID: 12700634
  25. role in divergence in signaling pathways involved in promotion of cell viability PMID: 12834262
  26. EGF and angiotensin II activation of phospholipase Cgamma through src is mediated by GIT1 PMID: 14523024
  27. EGF-mediated regulation of PEPT2 expression in a kidney cell line PMID: 14559717
  28. epidermal growth factor-induced signaling sensitization by bradykinin is mediated by c-Src PMID: 14630916
  29. Mechanisms by which EGF reduced angiotensin II surface receptor density and stimulated actions in vascular smooth muscle cells were studied. PMID: 15254973
  30. Epidermal growth factor triggers caspase-independent pituitary cell death PMID: 15331766
  31. These results suggest that increases in transepithelial resistance accompanying AEC transdifferentiation and/or EGF exposure are mediated, at least in part, by changes in the pattern of expression of specific claudin isoforms. PMID: 15361518
  32. This entire ectodomain is further processed into a 70-kDa precursor and finally into the mature 5.9 kDa urinary EGF PMID: 15380929
  33. Linear signal transduction pathway involving PI3-kinase-dependent MAPK regulates EGF-induced DNA synthesis in mesangial cells by regulating c-fos and p27(Kip1) expression. PMID: 15701816
  34. The Epidermal Growth Factor induces transient and sustained ERK activation. PMID: 15793571
  35. The epidermal growth factor acts to cell differentiate and proliferate of PC12 cells. PMID: 15803132
  36. Neo-natal rats with intestinal injury have significantly lower levels of ileum EGF. PMID: 15968738
  37. ERK1/2 mediates EGF-induced rapid Rb phosphorylation at Ser780 and Ser795 PMID: 16126730
  38. EGF-based signaling cascades phosphorylate Cav1 and have roles in caveolae assembly PMID: 16332692
  39. Alpha(1)-adrenergic agonists activate the alpha(1D)-AR adrenergic receptors to stimulate protein secretion and the ectodomain shedding of epidermal growth factor (EGF) to transactivate the EGF receptor. PMID: 16760267
  40. It is concluded that EGF regulates pax2 & GAPDH abundance & proteolysis in renal tubular cells through a PI3K/Akt-sensitive pathway that does not involve mTOR PMID: 16885413
  41. betaFGF, EGF and TGFbeta up-regulated the VEGF/FLK-1 receptor system in rat pituitary GH3 cells PMID: 16944045
  42. proliferative capability of hepatocytes was impaired by continuous liver damage due, in part, to the decrease of a hepatocyte mitogen EGF, and that increased intrahepatic TGF-beta1 activated hepatic stellate cells PMID: 17203207
  43. Wound healing was suppressed by one-half upon epidermal growth factor titration with EGF-antibody. PMID: 17631610
  44. SO(2) increasedthe expressions of EGF, EGFR, and COX-2 on the transcription and translation levels in the lungs and tracheas from asthmatic rats. PMID: 17962899
  45. Cat.G-induced cardiomyocyte apoptosis involves an increase in EGFR-dependent activation of SHP2 that promotes focal adhesion kinase dephosphorylation and subsequent cardiomyocyte anoikis. PMID: 17975113
  46. specific signaling functions and induction of genes differentially required for enhanced effect of EGF- and TGF-beta1-induced oncogenic properties PMID: 17982486
  47. Enhancement of PPARgamma activity by curcumin interrupted PDGF and EGF signaling in activated hepatic stellate cells by reducing the phosphorylation levels of PDGF-betaR and EGFR, and by suppressing the receptor gene expression. PMID: 18332871
  48. Decreased food intake did not affect the expression of EGF, PTHLH, or LEP mRNA in mammary tissue. PMID: 18401831
  49. EGFR inhibition enhances apoptosis induced by TGF-beta in FaO rat hepatoma cells through an increased oxidative stress coincident with a change in the expression pattern of NOX enzymes. PMID: 18848961
  50. demonstrated a unique role for EGF as a mediator of dopamine-induced precursor cell proliferation in the subventricular zone PMID: 19433789

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Subcellular Location Membrane; Single-pass type I membrane protein.
Database Links

KEGG: rno:25313

STRING: 10116.ENSRNOP00000040920

UniGene: Rn.6075


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