Recombinant Escherichia coli Ribonuclease E (rne), partial

1. This study suggests that, rather than its role in the processing of any one particular substrate, its distributed functions on all the different substrates (mRNA, rRNA, and tRNA) are responsible for the essentiality of RNase E in E. coli. PMID: 28167522
2. Small RNAs processing and Hfq binding determinants for RNase E: RNase E cleaves any RNA fused to the 3' end. PMID: 26531825
3. bacteria producing RNase E, have nutritional requirements different from those of cells supplied with only the N-terminal catalytic region of RNase E and mitigation of RNase E deficiency by overexpression of RNase G, is also affected by carbon source. PMID: 23275245
4. Electrostatic potentials of were found to be conserved, highly positive, and spread over a large surface area encompassing four putative membrane-binding regions identified in the "large" domain. PMID: 22509045
5. Strains harbouring rne alleles that express variants of RNase E in which 5' sensing or direct entry are inactivated, are viable. PMID: 22074454
6. Increased abundance of R-loops in the rho and nusG mutants contributes to rescue the lethality associated with loss of the two RNase E cleavage pathways. PMID: 22026368
7. demonstrated that CsdA, whose expression is induced by cold shock, interacts physically and functionally with RNase E PMID: 15554978
8. The RNase E tetramer has two nonequivalent subunit interfaces, one of which is mediated by a single, tetrathiol-zinc complex; one or both interfaces organize the active site, which is distinct from the primary site of RNA binding. PMID: 15779893
9. Observed role of RNase E in sodB mRNA turnover. PMID: 15781494
10. crystal structures of the catalytic domain of RNase E as trapped allosteric intermediates with RNA substrates PMID: 16237448
11. RNase E is required for induction of the glutamate-dependent acid resistance system in a RpoS-independent manner PMID: 17213667
12. RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton PMID: 17242352
13. This paper demonstrated that RNase E, a key endonuclease responsible for mRNA degradation in E. coli, regulates cspE transcript stability, possibly through the assembly of a degradosome. PMID: 18177308
14. RNaseE and RNA helicase B play central roles in the cytoskeletal organization of the RNA degradosome PMID: 18337249
15. RraA and RraB have a conserved property to directly act on RNAse E-related enzymes and inhibit their ribonucleolytic activity. PMID: 18510556
16. Study shows that the arginine-rich RNA binding domain (ARRBD) of RNase E is important for the initial endoribonucleolytic cleavage of RNAI but dispensable for the endoribonucleolytic cleavages of the Rep mRNA. PMID: 19426759

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KEGG: ecj:JW1071

STRING: 316385.ECDH10B_1155