Recombinant Rat Transcription factor AP-1(Jun)

Code CSB-YP011972RA
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Source Yeast
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Code CSB-EP011972RA
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Source E.coli
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Code CSB-EP011972RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011972RA
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Source Baculovirus
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Code CSB-MP011972RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Jun
Uniprot No. P17325
Alternative Names Jun; Rjg-9Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog
Species Rattus norvegicus (Rat)
Expression Region 1-334
Target Protein Sequence MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGNLK PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GATGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells.
Gene References into Functions
  1. miR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun. PMID: 29440459
  2. These findings indicated that heat stress stimulation in IEC6 cells induced the proapoptotic role of NFkappaB by regulating HSF1 and cJun activation. PMID: 29257252
  3. AMPK is an important negative regulator of Schwann cell myelination in the peripheral nervous system, and this regulation role may rely on c-Jun activation. PMID: 27194296
  4. Data show that miR-672-5p bound to the 3' UTR of the JUN gene, indicating that JUN is a target of miR-672-5p. PMID: 29339068
  5. Results suggest that mammalian target of rapamycin (mTOR) may act via transcription factor AP-1 (AP-1) to regulate vascular endothelial growth factor (VEGF) expression. PMID: 27458160
  6. These findings indicate that c-Jun induces PLCgamma1 expression transcriptionally and enhances rapid epithelial restitution after injury by activating Ca(2+) signal. PMID: 28100486
  7. The results suggest that an increase in the expression of PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and importin-alpha3 expression/activity participates in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation during endotoxemia and thus have a beneficial effect in septic shock treatment PMID: 26875149
  8. The aim of the present work was to assess the levels of mRNA encoded by genes c-jun and c-fos and the ratio of expression levels of these genes in various regions of the neonatal rat brain after the administration of dexamethasone PMID: 27239846
  9. These findings indicate that CORM-3 pretreatment interferes with JNK/AP-1 signaling and suppresses LPS-induced upregulation of the proadhesive phenotype in hCMEC/D3. PMID: 25098198
  10. nerve injury induces Schwann cell activation of c-Jun by phosphorylation, which, in contrast to in sensory neurons, is JNK independent. PMID: 24877090
  11. the activated SphK1-S1P signaling pathway in glomerular mesangial cells under diabetic conditions is closely associated with AP-1 to form a positive feedback loop. PMID: 24342046
  12. The present study investigated whether NPY Y1 receptor (Y1R) participated in activator protein-1 (AP-1)-mediated feeding. PMID: 24225225
  13. IL-1beta-induced proliferation is possibly mediated by the IL-1R1, JNK, and AP-1 pathways in rat hepatic stellate cells. PMID: 23992404
  14. c-Jun/AP-1 activation regulates hepatic alterations in nonalcoholic steatohepatitis PMID: 24492282
  15. JNK1 and c-Jun were shown to be major targets of DCA. PMID: 24421392
  16. Expression of MMP-7, c-Jun and c-Fos were increased in skin photoaging. PMID: 23870463
  17. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
  18. These findings indicated that induction of c-jun gene expression plays a pivotal role in the survival of injured motoneurons PMID: 23506737
  19. PCB126 could promote the proliferation of mesenchymal cells and upregulate the expression of c-fos and c-jun. PMID: 22611921
  20. The reduction in the bile acid pool size was found to delay the liver regeneration, which may be caused by the down-regulation of FXR and c-Jun expression. PMID: 20155456
  21. All-trans retinoic acid suppressed the mRNA expression of JNK and AP-1, which inhibited proliferation and collagen production of hepatic stellate cells. PMID: 21181362
  22. c-Jun-induced sulfiredoxin mediates brain-derived neurotrophic factor (BDNF)-dependent neuroprotective effects against 3- nitropropionic acid (3-NP) toxicity in primary rat cortical neurons, at least in part. PMID: 22402332
  23. Hepatocyte cell death from SP600125/menadione was c-Jun dependent, but independent of c-Jun phosphorylation. PMID: 22644775
  24. The positive expression of c-jun in intestinal epithelial cells at the early development stage was much stronger and more extensive than that in mature rats. Expression lay in the top of villus. PMID: 12857463
  25. The decrease in Jun expressing neurons in hippocampus may be an adaptive reaction to acute anoxia. PMID: 21179834
  26. Neuronal apoptosis is related to the increase in Fos and Jun expression in cultured hippocampal neurons after anoxia/reoxygenation. PMID: 21180051
  27. YiGanKang Decoction could not decrease IL-1RI expression, but it could inhibit activity of AP-1 in rat HSCs induced by IL-1beta. PMID: 21925583
  28. Activator protein-1 siRNA was able to effectively inhibit the proliferation, migration, and dedifferentiation of vascular smooth muscle cells. PMID: 21818553
  29. Regulatory enhancer binding protein transcription factor AP-1 binding to the interleukin (IL)1A -889 polymorphic locus is characterized. PMID: 22634325
  30. MEK1/ERK2-mediated activation of c-Jun is involved in nontypeable H. influenzae-induced CXCL2 upregulation in the rat spiral ligament fibrocytes. PMID: 22379036
  31. The expression of C-fos, C-jun in the hippocampus of epileptic discharge transfer group rats was significantly lower than that of seizure group. PMID: 22097274
  32. The level of JNK and c-Jun phosphorylation increases obviously in lungs of rats with paraquat poisoning. PMID: 19080378
  33. HB-EGF intestinal cytoprotection is mediated, in part, by downregulation of the expression of AP-1 transcription factor after intestinal I/R injury. PMID: 21063128
  34. The expression of immediate-early gene c-Jun increased shortly after optic nerve injury. PMID: 21092560
  35. The c-fos and c-jun mRNAs were transiently expressed in corneal and lens epithelial cells after blunt trauma. PMID: 16039502
  36. HDAC7 is a neuroprotective protein acting by a mechanism that is independent of its deacetylase activity but involving the inhibition of c-jun expression. PMID: 21118817
  37. Zinc deficiency affects the modulation of transcription factors AP-1, NF-kappaB and NFAT in fetal brain. PMID: 20092996
  38. Sodium tanshinone IIA sulfonate could ameliorate Ang II-induced cardiomyocyte hypertrophy by inhibiting c-fos and c-jun mRNA expression. PMID: 18846332
  39. X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes PMID: 20170659
  40. Silencing of either c-Fos or c-Jun also depressed the norepinephrine-mediated increases in PLC beta(1), beta(3) and gamma(1) protein content and activity in an isozyme specific manner. PMID: 19538471
  41. essential role of the MEK/ERK/AP-1 pathway in the disruption of actin cytoskeleton and cell spreading PMID: 20942268
  42. There was no difference of expression of c-jun among control and genistein- and estrogen-treated osteoblasts. PMID: 18646529
  43. After TNF-alpha stimulation of cardiac fibroblasts, AP-1 expression increased significantly. Qiangxin Decoction could reduce the expression of AP-1. PMID: 18782540
  44. Oxidant stress and the lipid peroxidation product HNE cause synergistic overactivation of the JNK/c-Jun signaling pathway in hepatocytes PMID: 20501438
  45. Positive expression of c-jun occurred 15 min after brain concussion, and reached the peak at 3 h after brain concussion. PMID: 20232736
  46. c-Jun phosphorylation correlates with the cellular events leading to motoneuron death and p-c-Jun may not be related with axonal regeneration of injured motoneurons PMID: 20096669
  47. Sodium fluoride increased the proliferation of rat osteoblasts and induced the expression of c-Fos and c-Jun genes. PMID: 11860940
  48. Hydroxyethyl starch 130/0.4 can inhibit LPS-induced acute lung injury by depressing expression of p-P38 and AP-1 activation in lung. PMID: 19439112
  49. These findings reveal the basis for thrombin induction of endothelial arginase I and indicate that arginase inhibition may be an attractive therapeutic alternative in the setting of arterial thrombosis and its associated endothelial dysfunction. PMID: 20032511
  50. Iodine deficiency leads to the activation of c-Jun and TGF-beta1 in kidney. PMID: 19737467

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Subcellular Location Nucleus
Protein Families BZIP family, Jun subfamily
Database Links

KEGG: rno:24516

STRING: 10116.ENSRNOP00000011732

UniGene: Rn.93714

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