Mad Antibody

1. LTR sequence of the MDG4 retrotransposon contains the MAD protein binding site that affects the east-dependent repression PMID: 28510129
2. During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate receptors at neuromuscular junction synapses. PMID: 24353060
3. The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway. PMID: 23884941
4. Data show that dSmad2 directly influences Baboon's phosphorylation of Mad. PMID: 22563507
5. Mad has distinct signal transduction roles in the BMP and Wnt pathways depending on its phosphorylation state. PMID: 21990430
6. Nup154 controls nuclear localization of Mad transcription factor, but does not interact directly with it. PMID: 21696798
7. Yorkie and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified. PMID: 21238929
8. Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors. PMID: 20381612
9. importin-beta11 function interacts with the bone morphogenic protein pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function PMID: 20392948
10. Mad depletion or overexpression produced Wingless-like embryonic segmentation phenotypes PMID: 19657393
11. The downstream transcription factor Mothers against dpp is essential for the normal structural and functional development of the Drosophila neuromuscular junction, a synapse that displays activity-dependent plasticity. PMID: 12672013
12. compared patterns of two related cellular responses, both signal-dependent phosphorylation of the BMP-regulated R-SMAD, MAD, and signal-dependent changes in levels and sub-cellular distribution of the co-SMAD Medea PMID: 14534137
13. a complex of the homologous Drosophila Smad proteins, Mad and Medea, is capable of concerted binding to GC-rich and SBE sites separated by as much as 20 bp. PMID: 17610966
14. A combinatorial enhancer recognized by Mad, TCF, and Brk first activates then represses dpp expression in the posterior spiracles of Drosophila. PMID: 18068697
15. Results describe the crystal structure of the MH2 domain of Mad, which closely matches those of other Smad MH2 domains, is reported at 3.2 A resolution. PMID: 18997322
16. phosphorylation of Mad by Nmo ensures normal accumulation and distribution of Mad and thereby fine tunes BMP signaling in motor neurons PMID: 19451277

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KEGG: dme:Dmel_CG12399

STRING: 7227.FBpp0304648

UniGene: Dm.7367