SPR Antibody

Datasheet

Code	CSB-PA546692XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) SPR Polyclonal antibody

Uniprot No.

Q8SWR3

Target Names

SPR

Alternative Names

SPR antibody; CG16752 antibody; Sex peptide receptor antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) SPR protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior. MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons. SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying. The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk).

Gene References into Functions

Data show that female sleep is reduced by male-derived sex Peptide (SP) SP acting through the canonical sex peptide receptor (SPR) within the same neurons responsible for altering other postmating responses (PMRs). PMID: 27658900
Results suggested that the SP/SPR-mediated post-mating responses was established in the lineage of the D. melanogaster species group. PMID: 27230918
SPR peptide modulates female chemosensory processing upon mating in Drosophila. PMID: 27145127
important in stabilizing sleep in both males and females PMID: 25333796
MIPs likely function as ancestral ligands of SPRs and could place evolutionary constraints on the MIP/SPR class. PMID: 20458515
Data show that mating status modulates food choice in females, that it relies on the action of the sex peptide receptor in sensory neurons, and that neuronal TOR/S6K function affects this decision, possibly signaling the fly's current nutritional status. PMID: 20471268
females that lack the sex peptide receptor (SPR, also known as CG16752), either entirely or only in the nervous system, fail to respond to SP and continue to show virgin behaviours even after mating PMID: 18066048
acts in the female flies to detect male Sex-peptide and trigger increased egg laying and reduced sexual receptivity PMID: 18334196

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

In the female, expressed in the reproductive organs; strongly expressed in the spermathecae and the lower oviduct. No expression in the male reproductive organs. In the central nervous system of both sexes, it is expressed in the brain and ventral nerve c

Database Links

KEGG: dme:Dmel_CG16752

STRING: 7227.FBpp0070744

UniGene: Dm.12998

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