Recombinant Mouse Gastrin(Gast),partial

Code CSB-YP009273MO
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Source Yeast
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Code CSB-EP009273MO
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Source E.coli
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Code CSB-EP009273MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009273MO
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Source Baculovirus
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Code CSB-MP009273MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Gast
Uniprot No. P48757
Alternative Names Gast; Gas; Gastrin [Cleaved into: Gastrin-71; G71); Big gastrin; Gastrin-34; G34); Gastrin]
Species Mus musculus (Mouse)
Expression Region 22-92
Target Protein Sequence SWKPRSQLQ DASSGPGTNE DLEQRQFNKL GSASHHRRQL GPQGPQHFIA DLSKKQRPRM EEEEEAYGWM DF
Protein Length partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Gene References into Functions
  1. Gastrin induces nuclear export and proteasome degradation of menin in duodenal glial cells. PMID: 28859856
  2. PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis. PMID: 28408643
  3. Renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure. PMID: 27780818
  4. Gastrin is expressed in insulin secreting cells of adult diabetic mice. PMID: 27864307
  5. increased circulating concentrations of progastrin provide a physiological advantage against systemic hypoxia in mice PMID: 25394662
  6. Ihh signaling mediates gastrin-induced proliferation of epithelial cells in stomachs of adult mice. PMID: 24859162
  7. Data indicate that epithelial Gli2 expression was sufficient to stimulate Il-1beta expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia. PMID: 23110168
  8. gastrins play an important direct role, unrelated to their ability to stimulate acid secretion, in hematopoiesis under conditions of iron deficiency. PMID: 21652729
  9. Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin. PMID: 21111741
  10. Regulation of mouse gastrin gene in vivo. Mechanisms involved in transcriptional control of the gastrin gene. PMID: 21051525
  11. RegI and gastrin may synergistically regulate gastric mucosal proliferation during certain pathological settings like wound healing PMID: 19969026
  12. To examine the importance of gastrin or its receptors during development in general and for gastric physiology specifically both have been knocked out. PMID: 11713979
  13. stimulates the growth of gastric pit cell precursors by inducing its own receptors. PMID: 11804858
  14. Endocrine gastrin may have a role in the colonic adenoma carcinoma sequence. Hyper-gastrinaemia may promote proliferation of human colonic adenomas that express CCK-2 receptor isoforms. PMID: 12189558
  15. Parietal cells were found to be significantly smaller in the mutant cell preparations, suggesting that gastrin stimulation modulates parietal cell morphology. PMID: 12388185
  16. essential physiologic role for gastrin in glucose homeostasis; however, the gastrin gene is not essential for murine islet development or the adaptive islet proliferative response to beta-cell injury. PMID: 14517799
  17. gastrin promoter is activated by transforming growth factor-beta/Smad and Wnt signaling pathways PMID: 15292219
  18. gastrin expression, possibly contributing to neoplastic progression, is induced by synergistic Wnt and Ras signaling pathway PMID: 16139800
  19. The aim of this study was to evaluate changes in the acid-secreting parietal cell in gastrin-deficient (GAS-KO) mice. PMID: 16278279
  20. Hypergastrinemia increases regeneration of intestinal epithelia following diverse forms of injury. PMID: 16618411
  21. gastrin can induce apoptosis in gastric epithelial cells and contribute to the development of gastric carcinogenesis PMID: 16894354
  22. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. PMID: 17064691
  23. Gastrin regulates TFF2 transcription through a GC-rich DNA-binding site and a protein kinase dependent pathway. PMID: 17332476
  24. Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells. PMID: 18567601
  25. Results suggest that RNAi targeting of gastrin could serve as an effective treatment for pancreatic cancer. PMID: 19465883

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Subcellular Location Secreted
Protein Families Gastrin/cholecystokinin family
Tissue Specificity Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas.
Database Links

KEGG: mmu:14459

STRING: 10090.ENSMUSP00000017309

UniGene: Mm.4767

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