Cam Antibody

Code CSB-PA216699XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Cam Polyclonal antibody
Uniprot No.
Target Names
Cam
Alternative Names
Cam antibody; CG8472Calmodulin antibody; CaM antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Cam protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance.
Gene References into Functions
  1. Asp-CaM complex has a critical role in centrosome-pole cohesion and centrosome inheritance in neural stem cells PMID: 26620907
  2. Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does. PMID: 25031429
  3. characterized the interdomain motions in the calcium-bound state of calmodulin (Ca(2+)-CaM) using NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations PMID: 24530797
  4. Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V. PMID: 12441389
  5. null behavioral phenotype originates in the nervous system and involves a calmodulin function that requires calcium binding to all four sites of the protein PMID: 14668380
  6. the direct interaction of melatonin with intact calcium-saturated CaM is calcium-dependent; Molecular dynamics simulations follow the dynamics of melatonin in the binding pocket of CaM PMID: 15498938
  7. potential functional role for calmodulin in regulation of the glycolytic pathway PMID: 15527800
  8. A mutation to the gene encoding calmodulin deregulates muscle contraction. PMID: 15557269
  9. Drosophila CaM is able to fully activate inducible nitric oxide synthase (iNOS); moreover, iNOS activation by CaM, like neuronal NOS, is not dependent on Ca2+ being bound to all four Ca2+-binding sites, but has specific and distinct requirements. PMID: 15896003
  10. Thus, Calmodulin and Abelson tyrosine kinase are key signaling molecules working synergistically to transduce both midline attractive and repulsive cues. PMID: 18243630

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Subcellular Location
Cytoplasm, cell cortex.
Protein Families
Calmodulin family
Database Links

KEGG: dme:Dmel_CG8472

STRING: 7227.FBpp0293502

UniGene: Dm.577

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