Recombinant Mouse Tissue-type plasminogen activator (Plat)

1. Sata suggest that tissue-type plasminogen activator (tPA) regulates nocturnal wheel-running activity, and that tPA differentially affects suprachiasmatic nucleus-driven nocturnal activity rhythms and activity driven by fasting or temporal food restriction. PMID: 29370799
2. Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP/NF-kappaB/Cox-2 in endothelial cells, endothelial MMP-2 and MMP-9 activation, and subsequent pro-apoptotic molecule in neurons after oxygen/glucose deprivation and reperfusion. PMID: 28539818
3. Tissue plasminogen activator was found to be restricted to subsets of excitatory pyramidal glutamatergic neurons. PMID: 26377106
4. analysis of mutations in genes co-segregating with the targeted Plat allele, including several potential null mutations PMID: 27079292
5. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity. PMID: 28684538
6. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms. PMID: 28754830
7. A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA). PMID: 27531677
8. While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis. PMID: 27427941
9. mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA PMID: 27959956
10. administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes PMID: 26929275
11. strategies contributing to promote either endogenous production of tPA or its associated EGFR-linked signaling pathway may have beneficial effects following brain injuries such as stroke. PMID: 26068590
12. Plasminogen activation contributes to wound repair and suggest that adenosine A2A receptor activation promotes wound closure by a mechanism that depends on tPA. PMID: 25991438
13. Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK, Rac-1, and NF-kappaB. PMID: 25131752
14. the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator PMID: 26176694
15. Erythropoietin protects mouse renal tubular basement membrane by promoting bone marrow cells to generate and secrete miR-144, which, in turn, inhibits activation of the tPA/MMP9-mediated proteolytic network. PMID: 26469975
16. tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity. PMID: 26377459
17. Results demonstrate that synaptic potentiation results in tissue plasminogen activator-dependent reelin processing and suggest that extracellular proteolysis of reelin may regulate reelin signaling in the adult brain PMID: 24892761
18. data implicate MCP-1 as the key molecule governing tPA-induced fluid accumulation. The role of MCP-1 in the development of other exudative effusions warrants examination. PMID: 25474480
19. Data indicated that suggest that tPA modulates emotion in a social context through the function of the prefrontal cortex. PMID: 25499620
20. in vivo and in vitro evidence showing that this aggravation is correlated with a decrease in lipoprotein receptor-related protein 1-mediated hepatic clearance of tPA in alcohol-exposed mice. PMID: 25922513
21. Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA) followed by delayed synthesis and release of urokinase plasminogen activator (uPA) from injured brain. PMID: 25673638
22. tPA promoted M1 macrophage survival through its receptor LRP-1-mediated novel signaling cascade involving Erk1/2, p90RSK, and p38, which leads to the accumulation of these cells in the injured kidneys PMID: 25670857
23. gene deficiency results in aggravation of experimental autoimmune myasthenia gravis PMID: 24423642
24. plg-/- and tPA-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity PMID: 24612416
25. Neural progenitor cells from tPA knock-out mice show impaired neurite outgrowth compared to wild-type. PMID: 23925701
26. Data suggest that tPA is required for bone repair and osteoblast proliferation; bone repair of the femur is delayed in tPA knockout mice, unlike that in wild-type mice (or uPA [urokinase-type plasminogen activator] knockout/wild-type mice). PMID: 24918201
27. Endogenously released tPA promotes neutrophil transmigration to reperfused tissue via proteolytic activation of plasmin and gelatinases. PMID: 24764453
28. TPA played an essential role in augmenting circulating endothelial progenitor cells, angiogenesis, and blood flow in the ischemic limb in a murine model. PMID: 24290069
29. tPA is sufficient to induce interleukin-1beta and phosphorylated extracellular signal-regulated kinase (ERK) expression in astrocyte cultures. PMID: 23707980
30. excess tPA/plasmin, through separate downstream molecular mechanisms, regulates postnatal Purkinje neuron (PN) dendritogenesis, synaptogenesis, mitochondrial structure and function, and selective PN viability PMID: 23674688
31. Our data indicate that tPA turns on a cell signaling pathway that protects neurons from the deleterious effects of excitotoxicity. PMID: 23063501
32. Chronic phase shifts resulted in decreased tissue-type plasminogen activator mRNA expression in the liver. PMID: 23249568
33. The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes. PMID: 23082219
34. Altogether, our data provide the first evidence that tPA influences spatial memory through its preferential interaction with GluN2D subunit-containing NMDARs. PMID: 22972996
35. activates the NF-kappaB pathway in macrophages through a signaling pathway involving annexin A2/CD11b-mediated integrin-linked kinase PMID: 22677557
36. This study provides new evidences supporting that tPA plays a cytokine-like role in glial activation by triggering receptor-mediated intracellular signaling circuits. PMID: 22162045
37. This study finding showed that the tPA/plasmin cascade may act downstream of ChABC to allow for synergistic sensory and motor improvement compared with each treatment alone and suggest a potential new approach to enhance functional recovery after SCI. PMID: 22016526
38. role in the nasal mucosa reconstruction in allergic rhinitis PMID: 21339035
39. synthetic nonadecapeptide binds to the B region and promotes the activation of plasminogen by t-PA, and then induced effective thrombolysis PMID: 21392255
40. tPA protects white matter from stroke-induced lesions PMID: 21576385
41. Voluntary physical activity, but not locked wheel exposure, induced a robust increase in hippocampal mature BDNF protein levels, as well as in p11 and tPA mRNA expression; and also promoted antidepressive effects and improved learning PMID: 21371535
42. phosphodiesterase-III inhibitor prevents the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA PMID: 21151895
43. Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice PMID: 21383198
44. tPA activity is regulated reversibly in an experience-dependent manner in the adult hippocampus PMID: 20974200
45. Data indicate that the neuroprotective effect of neuroserpin is due to inhibition of plasmin-mediated excitotoxin-induced cell death and is independent of neuroserpin's ability to inhibit tissue plasminogen activator activity. PMID: 20864675
46. Both tissue-type PA (tPA) and urokinase-type PA (uPA) bind to NMDA-R1 and reverse this effect, thereby enhancing acetylcholine-induced tracheal contractility. PMID: 20097831
47. these results demonstrate a new function for tPA in the central nervous system, which most likely contributes to its pleiotropic functions. PMID: 20636282
48. Data suggest that the MSC mediated increased activation of tPA in astrocytes promotes neurite outgrowth after stroke. PMID: 20140248
49. We suggest that AVP secretion is critically regulated by tPA-dependent facilitation of AVP release from terminals and plasminogen-dependent increase of AVP permeability across microvessels possibly via laminin degradation. PMID: 20175210
50. Plasmin and its activators tPA and uPA play a role in the haematopoietic recovery. PMID: 19210287

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KEGG: mmu:18791

STRING: 10090.ENSMUSP00000033941

UniGene: Mm.154660