Recombinant Rat Tissue-type plasminogen activator (Plat)

1. t-PA expressed in ECs may help to form IT of the DA via activation of MMP-2 and disruption of IEL PMID: 29304073
2. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. PMID: 24129569
3. Regulation of PAI-1 activity in astrocytes by valproic acid may affect both physiological and pathological processes in the brain by upregulating tPA activity. PMID: 23378038
4. Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection. PMID: 22556277
5. Designed t-PA mutants with molecular properties that, in contrast to t-PA, do not induce neurotoxicity. PMID: 23301636
6. Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction. PMID: 23258228
7. NR2B as a novel proteolytic substrate of tPA, where tPA may directly interact with NR2B subunits leading to a change in pharmacological properties of NR2B-containing NMDA receptors. PMID: 22610100
8. mRNA, protein and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and mRNA of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were quantified in abdominal aorta (AA) and femoral artery (FA). PMID: 22071631
9. The induction of tPA by human marrow stromal cells after traumatic brain injury may be one of the mechanisms involved in promoting functional improvement after traumatic brain injury. PMID: 21355820
10. Hydrocortisone up-regulates PAI-1 expression in a tissue-specific manner along with down-regulation of tPA activity in both normal and inflammatory conditions. PMID: 21412817
11. PACAP stimulates the release of tPA which promotes cerebellar granule cell survival by a mechanism dependent upon its proteolytic activity. PMID: 21919910
12. Massive up-regulation of plasminogen activator inhibitor-1 (PAI-1) in astrocytes during subchronic and chronic inflammatory conditions leads to decreased tPA activity in the later stages of reperfusion injury. PMID: 21193004
13. Erigeron breviscapus injection can inhibit the expression of TNF-alpha and PAI-1, and increase the expression of tPA in rats with acute myocardial infarction. PMID: 21355198
14. Investigated the brain-protective molecular mechanism of TPA in rats. TPA derivates were intracerebroventricularly administered at 15 min before, and 15, 90, 120 min after middle cerebral artery occlusion. PMID: 20596602
15. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. PMID: 20068577
16. alpha-synuclein up-regulated MMP-9 and down-regulated tPA activity in rat primary astrocytes and microglia in ERK1/2 dependent fashion; suggests a role of alpha-synuclein via regulation of protease systems through modulation of ERK1/2 activity in brain PMID: 20026244
17. Both annexin II and TPA were detected on the plasma membrane in a study of the role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures as cells achieve confluence (annexin II)(tissue plasminogen activator) PMID: 11928811
18. a chemical sympathectomy study of regulation of the vessel wall release of tissue plasminogen activator by sympathetic nervous system neurons PMID: 12192298
19. Reciprocal actions of neural cell adhesion molecule and tissue plasminogen activator via a Ras-dependent mitogen-activated protein kinase signaling pathway in hippocampal neurons. PMID: 12387826
20. Enhanced release of enzymatically active tissue plasminogen activator from sympathetic neurons into artery walls and the blood accompanies the changes associated with vascular aging. PMID: 12548713
21. Low to moderate doses of rt-PA protect the microvascular basal lamina lamina during experimental focal cerebral ischemia, whereas high doses of rt-PA have the opposite effect, probably due to increased coactivation of MMP-2 and MMP-9. PMID: 12783121
22. after transient focal cerebral ischemia, there are time dependent changes in tPA expression PMID: 14512838
23. The 600 bp of the tPA promoter upstream of the transcription start site conveys cell specificity to tPA expression and an NF1 site within this region acts as a repressor. PMID: 15044208
24. tPA activity is rapidly increased in hippocampal neurons after glutamate stimulation, corresponding to an increase in translational activation of mRNA present at the time of stimulation. PMID: 15496678
25. These results suggest the importance of the t-PA/plasmin cascade during the early pathological stages of delayed neuronal death in the hippocampus following transient forebrain ischemia. PMID: 15882815
26. Sympathetic nerves are the primary source of stress-induced release of t-PA into and from the densely innervated resistance arteries and arterioles. PMID: 16019605
27. tPA upregulates brain MMP-9 levels in stroke in vivo PMID: 16051896
28. tPA is localized in dendrites and terminals of AVP-expressing neurons; tPA is released in an activity-dependent manner, suggesting that matrix-degrading proteases are candidate molecules to be concerned with the structural plasticity in the HNS. PMID: 16150423
29. tPA acts as a cytokine that binds to the cell membrane receptor LRP-1, induces its tyrosine phosphorylation, and triggers intracellular signal transduction to induce MMP9 gene expression PMID: 16303771
30. TPA resides in dense-core granules that traffic to postsynaptic dendritic spines and that can remain there for extended periods. Depolarization by potassium elicits exocytotic release of tPA from DCGs in spines that is dependent on calcium signaling. PMID: 16555239
31. Astrocyte-derived tPA and the proteolytic activity in the dorsal horn may be one of the essential factors involved in pain following root injury. PMID: 17299772
32. Sertoli cells isolated from rat testes at various ages in vitro secreted tPA in an age-dependent manner. PMID: 17992606
33. tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstream ILK signaling, thereby leading to myofibroblast activation. PMID: 18037995
34. The critical period of visual cortical plasticity, which occurs in early postnatal life, correlates well with tPA expression in the rat visual cortex. PMID: 18523654
35. function of the tPA during diapedesis of monocytes through brain endothelial barrier; monocytes induce the release of tPA by brain endothelial cells; tPA and ERK1/2 control the breakdown of the tight junction protein occludin. PMID: 18714030
36. The increase of tPA in the acute phase after hypoxic-ischemic brain damage may be helpful to clot dissolving, but it induces neuronal apoptosis and aggravates brain injury. PMID: 18947492
37. FSH-induced ERK1/2 and p38 MAPK activation is capable of regulating tPA production in cultured primary granulosa cells. PMID: 18982462
38. Our results demonstrated the involvement of tPA in the secondary pathogenesis after spinal cord injury as well as the therapeutic potential of hUCB. PMID: 19152029
39. t-PA and PAI-1 mRNA were decreased after sympathectomy and remained unchanged after AT1 receptors blockade PMID: 19403340
40. protein aggregates formed during neuronal injury provide a macromolecular, nonfibrin cofactor that promotes tPA-mediated plasmin formation and subsequent cell breakdown PMID: 19584397

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KEGG: rno:25692

STRING: 10116.ENSRNOP00000025764

UniGene: Rn.107102