Recombinant Human Melanoma-derived growth regulatory protein(MIA) (Active)

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Code CSB-AP000431HU
Product Type Other
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q16674
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized
Alias Melanoma inhibitory activity protein
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human A375 cell line is less than 5 μg/ml, corresponding to a specific activity of >200 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence GPMPKLADRK LCADQECSHP ISMAVALQDY MAPDCRFLTI HRGQVVYVFS KLKGRGRLFW GGSVQGDYYG DLAARLGYFP SSIVREDQTL KPGKVDVKTD KWDFYCQ
Research Area Immunology
Source E.coli
Gene Names MIA
Expression Region 25-131aa
Tag Info Tag-Free
Mol. Weight 12.1 kDa
Protein Description Full Length of Mature Protein
PubMed ID 7923218; 8550608; 12230496; 15489334; 15340161; 19807924; 22419821; 11331761
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Function Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
Subcellular Location Secreted
Protein Families MIA/OTOR family
Tissue Specificity All malignant melanoma cell lines tested and infrequently in glioma cell lines.
Database Links

HGNC: 7076

OMIM: 601340

KEGG: hsa:8190

STRING: 9606.ENSP00000263369

UniGene: Hs.646364

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