Cervical Cancer

Cervical cancer is a malignant tumor that occurs in the cervical region of the female reproductive system. The main cause of cervical cancer is human papillomavirus (HPV) infection, especially high-risk types of HPV, such as HPV types 16 and 18. Other associated risk factors include smoking, multiple sexual partners, early sexual initiation, multiple pregnancies and births, and immune deficiency. The clinical presentation of cervical cancer varies with the progression of the disease and may be asymptomatic in the early stages, but as the disease progresses, symptoms such as contact bleeding and abnormal vaginal bleeding may occur.

In terms of cervical cancer treatment, according to the stage of the cancer and the specific conditions of the patients, commonly used treatments include surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy. Surgery is usually applied to early stage cervical cancer, while radiotherapy and chemotherapy are commonly used in the treatment of middle and late stage cervical cancer. Targeted therapy and immunotherapy are emerging treatments in recent years, which are mainly used in the treatment of recurrent or advanced cervical cancer.

The current research and development of cervical cancer drugs are mostly focused on the following directions:

Immune checkpoint inhibitors: PD-1/L1 inhibitors such as pabolizumab (PD-1 inhibitor) have been approved by the U.S. FDA for the treatment of recurrent or metastatic cervical cancer with disease progression during or after chemotherapy. In addition, pabolizumab in combination with chemotherapy is also approved for the first-line treatment of patients with persistent, recurrent or metastatic cervical cancer whose tumors express PD-L1.
Antibody-drug couplers (ADCs): Tisotumab Vedotin (TV) is the first ADC approved for the treatment of cervical cancer in patients with recurrent or metastatic cervical cancer whose disease has progressed during or after chemotherapy.The Phase III innovaTV301 trial of TV for the second-line treatment of cervical cancer showed that, compared to conventional chemotherapy, the TV significantly reduced the risk of death and improved patients' overall survival (OS).
Bispecific Antibody: Cadonilimab (AK104), a bispecific antibody targeting PD-1 and CTLA-4 independently developed by a domestic company, has been applied for marketing for the treatment of recurrent or metastatic cervical cancer and has been granted priority review.

Cervical Cancer Drug Targets

Cervical Cancer Drug Target Related Products

● Target Proteins

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

ERBB2 (HER2)
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

TIGIT
CSB-MP675446HU

HFACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

ERBB3
CSB-MP007765HU

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC₅₀ is 12.32-15.74 ng/ml.

TF
CSB-MP023412HU

Measured by its binding ability in a functional ELISA. Immobilized TFRC (CSB-MP3648HU)at 2μg/mL can bind Human TF，the EC₅₀ is 58.72-77.84 ng/mL.

Product Name	Code	Target	Source	Tag Info
Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active)	CSB-MP004847HU	CCR8	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human CD226 antigen (CD226), partial (Active)	CSB-MP618996HU	CD226	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active)	CSB-MP005166HU	CEACAM6	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human papillomavirus type 16 Protein E7 (E7) (Active)	CSB-EP365855HMLg5	E7	E.coli	N-terminal 6xHis-tagged and C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active)	CSB-MP007765HU	ERBB3	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005281HU	HAVCR2	Mammalian cell	C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005291HU	HAVCR2	Mammalian cell	C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active)	CSB-AP005341MO	Havcr2	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active)	CSB-AP004551HU	IL15RA	Mammalian cell	C-terminal Fc-tagged
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active)	CSB-AP004801MO	Il15ra	Mammalian cell	C-terminal Fc-tagged

● Cell Lines

CT26/Human ROR1 Stable Cell Line

CSB-SC004847HU2

Untransfected CHO-K1 cells (green line) and transfected Human CCR8 CHO-K1 stable cells (red line) were stained with anti-CCR8 antibody (CSB-RA004847A1HU) (2µg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CT26/Human ROR1 Stable Cell Line

CSB-SC004847HU3

Untransfected CT26 cells (green line) and transfected Human CCR8 CT26 Stable cells (red line) were stained with anti-CCR8 antibody (2µg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CT26/Human ROR1 Stable Cell Line

CSB-SC004847MO

Untransfected CHO-K1 cells (green line) and transfected Mouse CCR8 CHO-K1 Stable cells (red line) were stained with anti-Mouse CD198-PE antibody (2µg/1*10⁶ cells) and analyzed with flow cytometry.

● Recombinant antibodies

ALPP Recombinant Monoclonal Antibody
CSB-RA183247A0HU

Overlay Peak curve showing HepG2 cells surface stained with CSB-RA183247A0HU (red line) at 1:50.

CCR8 Recombinant Monoclonal Antibody
CSB-RA004847A1HU

Untransfected HEK293T cells surface (green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 antibody (2µg/1*10⁶ cells)。

CEACAM5 Recombinant Monoclonal Antibody
CSB-RA005165MA3HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

Product Name	Code	Target	Species Reactivity	Tested Applications
ALPP Recombinant Monoclonal Antibody	CSB-RA183247A0HU	ALPP	Human	ELISA, WB, IHC, FC
CA9 Recombinant Monoclonal Antibody	CSB-RA614990A0HU	CA9	Human	ELISA, IHC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847A1HU	CCR8	Human	FC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847MA3HU	CCR8	Human	FC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847MA2HU	CCR8	Human	FC
CCR8 Recombinant Monoclonal Antibody	CSB-RA004847MA4HU	CCR8	Human	FC
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ENTPD1 Recombinant Monoclonal Antibody	CSB-RA568544A0HU	ENTPD1	Human	ELISA, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody	CSB-RA588766A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA2HU	ERBB2	Human	ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody	CSB-RA937008A0HU	ERBB3	Human	ELISA, IF
FLT1 Recombinant Monoclonal Antibody	CSB-RA940669A0HU	FLT1	Human, Mouse	ELISA, WB, IHC, FC
IGF1R Recombinant Monoclonal Antibody	CSB-RA011087MA1HU	IGF1R	Human	ELISA, FC
IL17A Recombinant Monoclonal Antibody	CSB-RA624104MA1HU	IL17A	Human	ELISA
IL2RA Recombinant Monoclonal Antibody	CSB-RA011649MA1HU	IL2RA	Human	ELISA, IF
MUC16 Recombinant Monoclonal Antibody	CSB-RA941216A0HU	MUC16	Human	ELISA, IHC
MUC16 Recombinant Monoclonal Antibody	CSB-RA973154A0HU	MUC16	Human	ELISA, IHC
NECTIN4 Recombinant Monoclonal Antibody	CSB-RA822274A0HU	NECTIN4	Human	ELISA
NT5E Recombinant Monoclonal Antibody	CSB-RA978310A0HU	NT5E	Human	ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody	CSB-RA240597A0HU	PDCD1	Human	ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody	CSB-RA792129A0HU	TOP1	Human	ELISA, WB, IHC, FC, IP

● ELISA Kits

Product Name	Code	Target	Detection Range	Sensitivity
Human Placental alkaline phosphatase,PLAP ELISA Kit	CSB-E09160h	ALPP	84 pg/mL-2000 pg/mL	34 pg/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit	CSB-EL002476HU	AXL	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit	CSB-EL002476MO	AXL	31.25 pg/ml-2000 pg/ml	7.81 pg/ml
Human Carbonic Anhydrase 9(CA9) ELISA Kit	CSB-E13266h	CA9	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human CD226 antigen(CD226) ELISA kit	CSB-EL004901HU	CD226	0.9 ng/mL-60 ng/mL	0.22 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit	CSB-E04767h	CEACAM5	5 ng/mL-120 ng/mL	2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit	CSB-E13925m	CEACAM5	62.5 pg/mL-4000 pg/mL	15.6 pg/mL
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit	CSB-EL005166HU	CEACAM6	0.83 ng/mL-20 ng/mL	0.33 ng/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human Ectonucleoside triphosphate diphosphohydrolase 1(ENTPD1) ELISA kit	CSB-EL007690HU	ENTPD1	23.44 pg/mL-1500 pg/mL	5.86 pg/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit	CSB-E11161h	ERBB2	0.156 ng/mL-10 ng/mL	0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit	CSB-EL007765HU	ERBB3	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse Vascular endothelial cell growth factor receptor 1,VEGFR-1/Flt1 ELISA kit	CSB-E04762m	FLT1	1.56 ng/mL-100 ng/mL	0.39 ng/mL
Rat Vascular endothelial cell growth factor receptor 1,VEGFR-1/Flt1 ELISA Kit	CSB-E07350r	FLT1	1.56 pg/mL-100 pg/mL	0.39 pg/mL
Human FMS-like tyrosine kinase 3,Flt3 ELISA Kit	CSB-E04556h	FLT3	62.5 pg/mL-4000 pg/mL	15.6 pg/mL