EPOR Antibody

Code CSB-PA980670
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA980670(EPOR Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA980670(EPOR Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No. P19235
Target Names EPOR
Alternative Names EPO R antibody; EPO Receptor antibody; EPO-R antibody; epor antibody; EPOR_HUMAN antibody; Erythropoietin receptor antibody; Erythropoietin receptor precursor antibody; MGC138358 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthetic peptide of Human EPOR
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; FUNCTION
Gene References into Functions
  1. Here, we present two crystal structures of the human JAK2 FERM and SH2 domains bound to Leptin receptor (LEPR) and Erythropoietin receptor (EPOR), which identify a novel dimeric conformation for JAK2. PMID: 30044226
  2. EpoR role in the proliferation and survival of non-small cell lung cancer cells PMID: 29345289
  3. These results highlight the high intrinsic specificity of transmembrane domain interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of transmembrane domain interactions and the activity of transmembrane proteins. PMID: 28869036
  4. Study reports for the first evidence that EPOR modulates breast cancer cell morphology changes upon tamoxifen treatment, which result in increased formation of cell protrusions and subsequent cell death and, proposes sustained AKT phosphorylation in EPOR-overexpressing cells as a mechanism that can lead to EPOR-induced tamoxifen resistance. PMID: 28714517
  5. Authors retrospectively investigated whether TFR2 isoforms and EPOR are differentially expressed in MDS patients and whether the expression is associated with patients' clinical outcomes. PMID: 26914246
  6. High EPOR expression is associated with monoclonal gammopathy of undetermined significance and multiple myeloma. PMID: 26919105
  7. EPO-mediated EPOR signaling reduced the viability of myeloma cell lines and of malignant primary plasma cells in vitro PMID: 27581518
  8. this study shows that EPO could directly promote tumor progression via EPO receptor-expressing macrophages PMID: 27262376
  9. No evidence of in vivo activation of the Epo-R in WAT could be documented despite detectable levels of Epo-R mRNA. CONCLUSION: Thus, in contradiction to animal studies, Epo treatment within a physiological relevant range in humans does not exert direct effects in a subcutaneous WAT. PMID: 27640183
  10. Overexpression of EPOR is associated with clear cell renal cell carcinoma. PMID: 27468719
  11. HIF-1alpha and EPO-R may be an indicator of the aggressiveness of invasive breast cancers PMID: 27629849
  12. These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL disease. PMID: 26846855
  13. We report for a first time that functional EpoR is expressed in human rhabdomyosarcoma cell lines as well as by primary tumors from RMS patients. PMID: 26412593
  14. erythrocyte lineage enforces exclusivity through upregulation of EKLF and its lineage-specific cytokine receptor (EpoR) while inhibiting both FLI-1 and the receptor TpoR (also known as MPL) for the opposing megakaryocyte lineage PMID: 26159733
  15. A new point mutation in EPOR induces a short deletion in congenital erythrocytosis. PMID: 26010769
  16. Data show that erythropoietin receptor antagonist EMP9 suppressed hemoglobin synthesis in xenografts of HeLa cells. PMID: 25874769
  17. Data suggest that erythropoietin receptor (EPOR) could be a target to overcome therapeutic resistance toward ionizing radiation or temozolomide. PMID: 25544764
  18. transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles PMID: 25418301
  19. while EPO can stimulate NO production, NO in turn can regulate EPOR expression in endothelial cells during hypoxia PMID: 24518819
  20. In HBV-related HCC, the levels of EpoR mRNA and protein in non-tumour cirrhotic livers were positively correlated with tumour cell differentiation, which is a favourable predictor of disease-specific survival. PMID: 23496059
  21. This study reveals high EPOR level as a potential novel positive prognostic marker in human lung lung adenocarcinoma. PMID: 24155958
  22. 3 novel EPOR mutations in primary familial and congenital polycythemia--Del1377-1411, a C1370A and G1445--were chimerized with EGFR to study signalling and metabolism of the chimeric receptors. PMID: 24533580
  23. Data show that erythropoietin receptor (EPOR) protein is expressed in breast cancer cells, where it appears to promote proliferation by an EPO-independent mechanism in estrogen receptor alpha (ERalpha) expressing breast cancer cells. PMID: 24502950
  24. Epo-R is expressed in bone marrow-derived macrophages from multiple myeloma and monoclonal gammopathy of undetermined significance patients. The Epo/Epo-R pathway may be involved in the regulation of angiogenic response occurring in MM. PMID: 23881169
  25. Data suggest that adipose tissue-specific disruption of EPO receptor does not alter adipose tissue expansion, adipocyte morphology, insulin resistance, inflammation, or angiogenesis. PMID: 23885016
  26. Sp1 may significantly affect the number of EPO-R molecules present on the surface of activated CD4(+) lymphocytes PMID: 23577103
  27. EPOR expression may be involved in tumor progression and proliferation in HER2-positive breast cancer.EPOR contributes to the mechanism of trastuzumab resistance in breast cancer. PMID: 23117856
  28. TAL1 binds to the EPO-R promoter to activate EPO-R expression PMID: 22982397
  29. High EPOR expression in OSCC is associated with an aggressive tumor behavior and poorer prognosis in the univariate analysis among patients with OSCC. PMID: 22639817
  30. Erythropoietin is capable of downregulating erythropoietin receptor when it acts early within HepG2 cells. PMID: 22227182
  31. the biology of the EpoR in ovarian cancer cells PMID: 22552716
  32. The absence of functional Epo receptor activity in human skeletal muscle indicates that the long-term effects are indirect and probably related to an increased oxidative capacity in this tissue PMID: 22384088
  33. a critical role for membrane raft in recruitment and assembly of Epo-R and signal intermediates into discrete membrane signaling units PMID: 22509308
  34. New knowledge concerning regulated EPOR expression and trafficking therefore is provided, together with new insight into mechanisms via which mutated EPOR-T polycythemia alleles dysregulate the erythron. PMID: 22253704
  35. These data support that EpoR is functional in melanoma and EpoR activation may promote melanoma progression, and suggest that Epo may stimulate angiogenesis and increase survival of melanoma cells under hypoxic condition in vivo. PMID: 21860424
  36. The expression of EPOR and TPOR on CD34+ CD59+ bone marrow cells are significantly higher than those on CD34+ CD59- cells of paroxysmal nocturnal hemoglobinuria patients. PMID: 22338178
  37. STAT5 phosphorylation levels of EPO and TPO receptors are elevated in bone marrow cells of patients with paroxysmal nocturnal hemoglobinuria. PMID: 22093990
  38. ETV6-RUNX1 directly activates ectopic expression of a functional EPOR and provides cell survival signals that may contribute critically to persistence of covert premalignant clones in children. PMID: 21900195
  39. EPOR signalling in tumour cells is involved in the control of glioma growth. PMID: 21749867
  40. EPO-R cytosolic lysine residues enhance receptor function, most probably through ubiquitination and/or other post-translational modifications. PMID: 21291419
  41. The Epo/EpoR complex plays a critical role in the adhesion and migration of rat fibroblasts, and its functional inactivation is associated with PLC-gammal-dependent reduction of cell-matrix adhesion and this also affects cell migration. PMID: 21360263
  42. Detected is a novel heterozygous frameshift mutation in exon 8 of the EPOR resulting in primary familial and congenital polycythaemia. PMID: 21437635
  43. EPOR is expressed in cells of acute leukemia, but the expression level in low. The EPOR expression rate shows no significant difference between AML and ALL. PMID: 19099624
  44. High EpoR is associated with angiogenesis in glioma. PMID: 20614229
  45. Tumor vessels exhibited EpoR, pJAK-2, and pSTAT-5 immunoreactivity PMID: 20336349
  46. results suggest that spermatozoa express EPO receptor on plasma membrane, which might act to protect these cells from damage after ejaculation. PMID: 20884294
  47. EpoR signaling is absolutely required for Parvovirus B19 replication in ex vivo-expanded erythroid progenitor cells after initial virus entry and at least partly accounts for the remarkable tropism of B19V infection for human erythroid progenitors. PMID: 20861249
  48. a regulatory role of EPO/EPOR pathway in human circulating endothelial precursors homeostasis PMID: 20700488
  49. Data show that sEpoR is detectable as a 27kDa protein in the serum of dialysis patients, and that higher serum sEpoR levels correlate with increased erythropoietin requirements. PMID: 20169072
  50. EpoR mRNA was detected in essentially all cell types examined, including primary endothelial, renal, cardiac, and neuronal cells but 10- to 100-fold lower than Epo-responsive cells PMID: 20124513
  51. EpoR mRNA levels in 209 cell lines representing 16 tumor types were low compared with erythropoiesis-stimulating agent-responsive positive controls. PMID: 20124514
  52. The level of EPO-R positively correlates to angiogenesis and progression of esophageal carcinoma. PMID: 18184464
  53. Expressions of EPOR show mutual correlations in primary ductal breast cancers, which suggest co-operation among the protein. PMID: 20164027
  54. Diverse binding epitopes of single-chain antibody induce signaling through the erythropoietin receptor. PMID: 20337434
  55. Data from competitive transplantation experiments in a mouse model suggest signaling through human EPOR regulates erythropoiesis and megakaryopoiesis. PMID: 19836979
  56. EPO induction of NO is dependent on the betaC-R and VEGF-R2; VEGF induction of NO is dependent on the expression of the betaC-R, and that the betaC-R and VEGF-R2 interact PMID: 19965681
  57. Results demonstrate the expression of EpoR in meningiomas; lower EpoR mean levels might be a useful marker for a higher recurrence risk, but further studies are needed to clarify the influence of EpoR on recurrences and the role of the different isoforms PMID: 19298633
  58. the overexpression of functional EpoR expression in about half of the analyzed clinical melanoma metastasis specimens and show anti-apoptotic as well as pro-migratory effects of Epo, which is of importance for the treatment of anemia in advanced melanoma PMID: 19536148
  59. Amino acid determinants of beta-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library PMID: 11884148
  60. REVIEW: Role of erythropoietin receptor in myelodysplastic syndrome and leukemia. PMID: 11999556
  61. The extracellular binding site for ERP is now characterized. The site is located in the membrane proximal, extracellular part of the receptor. ERP binds to a region on the EPOR that contains the same sequence as ERP PMID: 12021194
  62. evidence for pY429pY431 being a new high affinity binding site for SOCS-3 on the EpoR PMID: 12027890
  63. functional significance of expression in breast cancer PMID: 12118093
  64. Epo and Epo-R localized within glandular epithelial cells in both peritoneal endometriosis and eutopic endometrium. Epo-R expression lower in black peritoneal lesions. PMID: 12525458
  65. Expression of erythropoietin receptor splice variants in tumor cell lines. PMID: 12878211
  66. Majority of papillary thyroid carcinomas (PTC) from children and adolescents express EPO-R, a finding associated with favorable prognostic indicators and a lower risk of recurrence. PMID: 14584755
  67. Increased erythropoietin receptor expression is associated with advanced-stage disease, lymphovascular invasion, lymph node metastasis of endometrial carcinoma PMID: 15160341
  68. erythropoietin receptor and nitric oxide production are stimulated by erythropoietin and hypoxia in vascular endothelial cells PMID: 15205261
  69. These data demonstrate that EPO can promote differentiation of neuronal stem cells into astrocytes in an EPO receptor dependent manner, and this effect may be associated with the activation of ERK kinase and NF-kappaB pathway. PMID: 15249201
  70. activated Epo receptors appear to be quickly degraded after ubiquitination by 2 proteolytic systems that proceed successively PMID: 15358619
  71. Epression of erythropoietin receptor in prostate cancer cell lines suggesting that these cells may serve as useful experimental models for further studies of erythropoietin receptor function for growth regulation in prostate cancer. PMID: 15467711
  72. the erythropoietin-receptor pathway modulates survival of cancer cells PMID: 15480420
  73. The Erythropoietin Receptor mutations have been shown to cause the myeloproliferative disorders disease. PMID: 15572213
  74. detailed mapping of interactions of several signalling proteins with phosphorylated tyrosine-containing motifs in the cytosolic domain OF EPOR PMID: 15644415
  75. the TM-JM junction of EpoR forms an N-terminal helix cap required for function PMID: 15657048
  76. erythropoietin receptor was expressed in almost all samples in non-small cell lung carcinomas. PMID: 15709164
  77. Results showed that VHL disease-associated renal clear cell carcinomas and renal cysts coexpress and erythropoietin receptor and erythropoietin. PMID: 15709172
  78. Y285 and Y344 in the cytoplasmic domain of EPOR-ME may contribute to increased Epo sensitivity that is characteristic of primary familial and congenital polycythemia phenotype. PMID: 15878737
  79. CaM binds to the membrane-proximal EpoR cytoplasmic region and plays an essential role in activation of Jak2-mediated EpoR signaling PMID: 16084495
  80. data demonstrate that transformed, non-malignant and malignant prostate epithelial cells have functional EpoR PMID: 16161153
  81. No EPOR exon VIII mutations were found in members of 8 Greek families with primary familial and congenital polycythemia. PMID: 16608505
  82. findings show that three thyroid cancer cell lines expressed Epo and EpoR mRNA PMID: 16699298
  83. Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity. PMID: 16982687
  84. erythropoietin receptor is not ubiquitinated following erythropoietin stimulation in this cancer cell line, and there is no turnover of the receptor in either unstimulated or stimulated cells PMID: 17038666
  85. Doubt concerning the significance of previous immunohistochemical studies of EPOR expression in malignancy and emphasize the need for more specific anti-EPOR antibodies to define the true extent of EPOR expression in neoplastic tissue. PMID: 17110616
  86. The EpoR expression correlated significantly with apoptosis and correlated significantly with tumor size and was significantly associated with the presence of lymphovascular space involvement in Cervical cancers. PMID: 17145806
  87. The Epo receptor may be important for secretion, endothelial progenitor cell mobilization, and angiogenesis in ischemic tissue as well as Epo in peripheral vasculature of EpoR-deficient-rescued transgenic mice, compared with wild type. PMID: 17293480
  88. Recognition of a vascular EpoR system which is endowed with significant pathophysiological functions opens new exploitation horizons in cardiovascular medicine. PMID: 17363704
  89. upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic Alzheimer disease. PMID: 17483696
  90. A novel sporadic EPOR 1453G->A (Trp439Stop) mutation was detected. All familial erythrocytosis cases, varied in phenotype, presented the EPOR 1414C->G (Tyr426Stop) mutation. PMID: 17488692
  91. Five of the antibodies recognized recombinant rat and human EPOR in HEK293 cells by Western blotting, but the same antibodies yielded different and inconsistent results when using human UT-7 cells or rat brain tissue. PMID: 17524492
  92. Upregulation of EPOR is not uncommon for PCa and upregulated EPOR in high-grade PIN suggests upregulation of EPOR is an early event for prostate carcinogenesis. PMID: 17637760
  93. These results suggest that the erythropoietin-independent EpoR-signaling pathway plays a potential role in cell proliferation and angiogenesis in human pterygium. PMID: 17912463
  94. we provide evidence that expression of the erythropoietin receptor is a common feature of malignant mesothelioma cells cultured in vitro PMID: 17922127
  95. The EPO-R cytosolic domain is involved in its exit.Sequence motifs that participate in endocytosis can also modulate transport along the secretory pathway. PMID: 17995455
  96. HLA-G5 downregulates EPOR constitutive signaling of JAK2 V617F-expressing erythroleukemia cells, inhibiting cell proliferation via G1 cell cycle arrest. PMID: 18059484
  97. EpoR juxtamembrane regulatory motif essential for Epo-dependent JAK2 activation is not essential for the activation of JAK2V617F. PMID: 18158285
  98. Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia. PMID: 18250608
  99. Epo overexpression is an early event in the retina of diabetic patients, not associated with any change in EpoR. PMID: 18332162
  100. we have found no evidence that EpoR is overexpressed in tumours or gets to the surface of tumour cells. PMID: 18349818

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Involvement in disease Erythrocytosis, familial, 1 (ECYT1)
Subcellular Location Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform EPOR-S: Secreted
Protein Families Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EP
Database Links

HGNC: 3416

OMIM: 133100

KEGG: hsa:2057

STRING: 9606.ENSP00000222139

UniGene: Hs.631624

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