Recombinant Mouse Erythropoietin receptor(Epor)

Code CSB-CF007744MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P14753
Storage Buffer Tris-based buffer,50% glycerol
Species Mus musculus (Mouse)
Sequence APSPSLPDPKFESKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRTLQQKIWPGIPSPESEFEGLFTTHKGNFQLWLLQRDGCLWWSPGSSFPEDPPAHLEVLSEPRWAVTQAGDPGADDEGPLLEPVGSEHAQDTYLVLDKWLLPRTPCSENLSGPGGSVDPVTMDEASETSSCPSDLASKPRPEGTSPSSFEYTILDPSSQLLCPRALPPELPPTPPHLKYLYLVVSDSGISTDYSSGGSQGVHGDSSDGPYSHPYENSLVPDSEPLHPGYVACS
Source in vitro E.coli expression system
Gene Names Epor
Protein Names Recommended name: Erythropoietin receptor Short name= EPO-R
Expression Region 25-507
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Subcellular Location Isoform EPOR-F: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform EPOR-S: Secreted
Protein Families Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells.
Database Links

KEGG: mmu:13857

STRING: 10090.ENSMUSP00000006397

UniGene: Mm.2653

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Hematopoietic cell lineage

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