Recombinant Mouse Protein numb homolog (Numb)

1. Given the apparent absence of major NUMB dysfunction in LNX null animals PMID: 27889896
2. NUMB is necessary for establishing polarity in coelomic epithelium cells. PMID: 28360133
3. investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation. PMID: 28067668
4. These findings highlight the importance of Numb and Numbl in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis PMID: 27383182
5. RBM4 depletion reduced the expression of the proneural gene Mash1, and such reduction was reversed by an RBM4-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4-depleted neurons were rescued by RBM4-induced exon 9-lacking Numb isoforms. RBM4 modulates exon selection of Numb. PMID: 27009199
6. role in the mediation of TCR degradation PMID: 26507128
7. miR-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch to separate stem and non-stem cell fates robustly. PMID: 26849305
8. Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4. PMID: 26244698
9. Loss of Numb induces a p53-dependent senescence following skeletal muscle injury. PMID: 26503169
10. Numb is a regulator for constitutive expression and dynamic transport of mGlu1. PMID: 26621723
11. Numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the stem cell identity, where it sustains high p53 activity. PMID: 26598619
12. findings demonstrate that Nb and Nbl are intrinsic factors crucial for the renewal of CPCs in the PA2 and that the PA2 serves as a microenvironment for their expansion PMID: 24843018
13. Numb/Numbl control VEGF receptor endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels. PMID: 26069237
14. Nuclear localization of Numb in early thymocyte precursors favors p53 nuclear stabilization, whereas pre-T-cell receptor-dependent Numb nuclear exclusion promotes the p53 downmodulation essential for further differentiation. PMID: 25321479
15. Numb promotes the trafficking of Cnga1 in rod photoreceptor cilia. PMID: 25319694
16. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. PMID: 24336247
17. By ablating Numb and Numbl in different cardiac populations followed by lineage tracing, we determined that Numb and Numbl in the second heart field are required for outflow tract (OFT) and atrioventricular septation and OFT alignment. PMID: 24335256
18. Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. PMID: 23891977
19. Numb-deficient satellite cells have regeneration and proliferation defects. PMID: 24170859
20. we propose that NUMB maintains ameloblast progenitor phenotype at the cervical loop by downregulating the activated Notch1 protein and thereby inhibiting the mRNA expression of Shh. PMID: 23841055
21. identify TBC1D15 as a Numb-associated protein and demonstrate that its amino-terminal domain disengages p53 from Numb, triggering p53 proteolysis and promoting self-renewal and pluripotency PMID: 23468968
22. Data indicate that Wnt/beta-catenin signaling mediates nandrolone-induced Numb transcription. PMID: 23649620
23. Rbfox3-dependent Numb alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development. PMID: 23420872
24. Concomitant but not separate ablation of Numb and Numblike in the developing heart leads to increased Notch2 activity along with hypertrabeculation, reduced compaction, and ventricular septum defects. PMID: 22865640
25. In the developing mouse retina, we show that numb is required for normal cell-cycle progression at early stages and at late stages is critical for the production of terminal asymmetric cell divisions. PMID: 23197712
26. The more perpendicular/asymmetric cell division is, the more likely it is to segregate Numb preferentially to one daughter cell in mitotic lung epithelial progenitors. PMID: 22713487
27. the data demonstrate that Numb and Numblike have evolved to acquire at least partially distinct functions. PMID: 21893032
28. Numb regulates Notch1, but not Notch3, during myogenesis PMID: 21356309
29. The Numb functions in a feed-forward loop to promote chemotaxis of neural precursors, linking BDNF, an extracellular cue, to aPKC, a critical component of the intrinsic polarity machinery. PMID: 21571219
30. Numb is critical for maintaining cell-cell interactions in the pituitary intermediate lobe that are essential for proper cell placement. PMID: 21084383
31. Data show that Numb determines the levels of pre-TCR signaling in dividing thymocytes and, ultimately, the size of the pool from which mature T lymphocytes are selected. PMID: 20530794
32. Numb is indispensable for spindle assembly and chromosome alignment during mouse oocyte maturation. PMID: 20353726
33. Data propose that Numb can regulate the self-renewal of dermal and muscle progenitors during a lineage progression. PMID: 19785007
34. mNumb functions as a Notch-1 antagonist in immature thymocytes, but suppression of Notch-1 signaling at this stage does not alter gamma delta/alpha beta or CD4/CD8 T cell fate specification. PMID: 11907069
35. modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implied in neuronal death in Alzheimer disease PMID: 12025816
36. Numb has an important role in generating asymmetric cell divisions and diverse cell fates during mouse cortical development PMID: 12361975
37. mouse numb and numblike play redundant but critical roles in maintaining neural progenitor cells during embryogenesis, by allowing their progenies to choose progenitor over neuronal fates PMID: 12410312
38. mNumb splicing isoform has an inhibitory effect on Notch signaling, indicating its potential roles in the differentiation of pancreatic endocrine lineage. PMID: 14641329
39. Numb plays an essential role in the control of cortical morphogenesis, a process requiring precise regulation of neural progenitor cell proliferation, differentiation, and apoptosis. PMID: 14687546
40. role in the transition of a mitotic progenitor to a fully differentiated granule cell in the cerebellum PMID: 14729486
41. Numb-mediated asymmetric cell divisions, which diversify many cell fates in Drosophila melanogaster, represent a general mechanism in mammals for stem cells to balance self-renewal and differentiation. PMID: 15273690
42. evidence for previously unidentified functions of Numb and Numblike in sensory axon arborization by regulating Notch1 via the endocytic-lysosomal pathways PMID: 15598981
43. Rho kinase phosphorylates CRMP-2, and inactivates the ability of CRMP-2 to promote microtubule assembly and Numb-mediated endocytosis, during growth cone collapse PMID: 16260611
44. We observed that an increase in Numb expression is concomitant with Notch degradation in these cells. Thus, through Numb, GDNF might inhibit differentiation and allows the maintenance of the stem cell pool in the mouse seminiferous epithelium. PMID: 16467260
45. Loss of m-Numb and Numbl outside the embryonic nervous system also causes phenotypes similar to those exhibited by mice with defective Notch signaling. We further show that very little Numb protein is necessary for embryogenesis. PMID: 16508312
46. membrane localization of Numb is dynamically regulated by GPCR-activated phospholipid hydrolysis and PKC-dependent phosphorylation events. PMID: 16837553
47. Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation. PMID: 17115028
48. Removal of Numb/Numblike from postnatal SVZ progenitors and ependymal cells resulted in severe damage to brain lateral ventricle integrity and identified roles for Numb/Numblike in regulating ependymal wall integrity and SVZ neuroblast survival. PMID: 17174898
49. Study reports that ACBD3 is a Numb partner in cell-fate specification, ACBD3 and Numb proteins interact through an essential Numb domain, and the respective loss- and gain-of-function mutant mice share phenotypic similarities. PMID: 17418793
50. Both numb and numblike are dispensable for hemopoesis and lymphopoiesis in the adult mouse, despite their proposed role in neuronal stem cell development. PMID: 17513721

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KEGG: mmu:18222

STRING: 10090.ENSMUSP00000119303

UniGene: Mm.4390