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MEA Antibody

Datasheet
Code CSB-PA524055XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) MEA Polyclonal antibody
Uniprot No.
O65312
Target Names
MEA
Alternative Names
MEA antibody; EMB173 antibody; FIS1 antibody; MEDEA antibody; SDG5 antibody; SET5 antibody; At1g02580 antibody; T14P4.11Histone-lysine N-methyltransferase MEDEA antibody; EC 2.1.1.356 antibody; Maternal embryogenesis control protein antibody; Protein EMBRYO DEFECTIVE 173 antibody; Protein FERTILIZATION-INDEPENDENT SEED 1 antibody; Protein SET DOMAIN GROUP 5 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana MEA protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

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MEA Proteins

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Target Background

Function
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to prevent the proliferation of the central cell of the female gametophyte by repressing target genes before fertilization. After fertilization, it probably also regulates the embryo and endosperm proliferation and anteroposterior organization during seed development. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Interacts with the promoter and repress the transcription of genes such as PHE1 and PHE2, that are paternally active and maternally silenced genes.
Gene References into Functions
  1. TAF13 functions together with MEDEA and SWINGER, both members of a plant variant of Polycomb Repressive Complex 2 (PRC2)in transcriptional regulation during seed development. [MEDEA] PMID: 23506837
  2. functional requirement of the FIS-PRC2 is to balance parental genome contributions and to reduce genetic conflict. PMID: 23326241
  3. imprinted MEA expression mediated by this ICR is independent of DME and MET1, consistent with the lack of any significant DNA methylation in this region PMID: 22855791
  4. Parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. PMID: 19779546
  5. MEA imprinting is regulated by histone methylation. PMID: 16527743
  6. MEA-FIE PcG complex implies distinct functions that are dynamically regulated during reproduction. PMID: 16651654
  7. MEA and SWN perform partially redundant functions in controlling the initiation of endosperm development before fertilization in Arabidopsis. PMID: 16924116
  8. The evolution of MEA suggests a late origin of genomic imprinting within the Brassicaceae, whereas imprinting is thought to have originated early within the mammalian lineage PMID: 17637669
  9. Study presents data and analyses of sequence diversity of MEA in self-fertilizing and outcrossing Arabidopsis and its relatives, to help clarify the form of selection acting on this gene. PMID: 19126870

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Subcellular Location
Nucleus. Note=Excluded from the nucleolus.
Protein Families
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
Tissue Specificity
Expressed in unpollinated siliques that contain maturing gametophytes. Not expressed at early stages of floral development during early megagametogenesis.
Database Links

KEGG: ath:AT1G02580

STRING: 3702.AT1G02580.1

UniGene: At.10786

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