Recombinant Drosophila melanogaster Protein numb(numb) ,partial

Code CSB-YP322861DLU
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Source Yeast
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Code CSB-EP322861DLU
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Source E.coli
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Code CSB-EP322861DLU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP322861DLU
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Source Baculovirus
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Code CSB-MP322861DLU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names numb
Uniprot No. P16554
Alternative Names numb; CG3779; Protein numb
Species Drosophila melanogaster (Fruit fly)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Required in determination of cell fate during sensory organ formation in embryos. Functions in nuclei and seems to interact with nucleic acids.
Gene References into Functions
  1. Data suggest that Numb controls the balance between Notch receptor recycling and receptor targeting to late endosomes to regulate signaling output after asymmetric cell division in Drosophila neural progenitors. PMID: 27466320
  2. The authors find that Numb is regulated in part through its asymmetric and symmetric distribution during stem cell divisions; however, its de novo synthesis is also required during the differentiation of the enteroendocrine cells. PMID: 28533229
  3. Spdo is sorted toward late endosomes in a Numb-dependent manner. PMID: 25365996
  4. Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila. PMID: 23523245
  5. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor. PMID: 23523246
  6. Data show regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division. PMID: 23720047
  7. precise regulation of cortical aPKC kinase activity distinguishes the sibling cell identity in part by ensuring asymmetric partitioning of Numb into the future progenitor cell where Numb maintains restricted potential independently of regulation by aPKC. PMID: 22394487
  8. The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb. PMID: 21996673
  9. results reveal a novel mechanism by which Numb activity is tightly controlled, and highlight the novel role of Dronc in neural stem cell homeostasis PMID: 21558368
  10. the restricted ability of Numb to inhibit Notch signaling during asymmetric divisions PMID: 19906847
  11. Numb is needed in the lateral but not antennal lobe projection neurons or ventral projection neurons lineages to prevent the appearance of ectopic neuroblasts and to ensure proper self-renewal of neural progenitors. PMID: 20023159
  12. The need for Numb to direct Notch signaling correlated with a decrease in neuroblasts cell cycle time and may be a means for coping with multiple sibling pairs simultaneously undergoing fate decisions. PMID: 20023160
  13. Suppresses negative complementation between viable Abruptex mutations of the Notch gene. PMID: 11865711
  14. results suggest that Numb regulates cell fate by polarizing the distribution of the endocytic protein -Adaptin. PMID: 12194853
  15. These results show that binary cell death decision can be regulated by the unequal segregation of Numb at mitosis. Our study also indicates that regulation of programmed cell death modulates the final pattern of sensory organs in a segment-specific manner PMID: 12361960
  16. Results suggest a model in which Numb inhibits Notch signaling through the regulation of Sanpodo membrane localization. PMID: 12919675
  17. role in the development of Drosophila and vertebrate nervous systems PMID: 14670962
  18. Asymmetric segregation of Numb into one of the two daughter cells is absolutely essential for cell-fate specification in the Drosophila peripheral nervous system. PMID: 16139215
  19. precise temporal and quantitative regulation of Numb and Notch activity is not only required during fate decisions but also later during glial differentiation and migration PMID: 17157832
  20. Study concludes that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal. PMID: 17182871
  21. Data show that the tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. PMID: 18342578

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Subcellular Location Nucleus
Database Links

KEGG: dme:Dmel_CG3779

STRING: 7227.FBpp0303726

UniGene: Dm.4492

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